CFTR

Inhibitory Selectivity

CFTR Products

Catalog No. Information Product Use Citations Product Validations
S7139

CFTRinh-172

CFTRinh-172 (CFTR inhibitor 172) is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.

S8094

GlyH-101

GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM.

S0198

PPQ-102

PPQ-102 (CFTR Inhibitor IV) is a potent inhibitor of CFTR. PPQ-102 can completely inhibit CFTR chloride current with IC50 of ~90 nM.

S3272

Steviol (Hydroxydehydrostevic acid)

Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902), a major metabolite of the sweetening compound stevioside, inhibits CFTR activity, reduces AQP2 expression and promotes AQP2 degradation.

S6911

Nesolicaftor (PTI-428)

Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression.

S8795

FDL169

FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.

S8535

Galicaftor (ABBV-2222)

Galicaftor (ABBV-2222, GLPG2222) is a potent corrector of CFTR for the treatment of Cystic Fibrosis (CF).

Catalog No. Information Product Use Citations Product Validations
S7139

CFTRinh-172

CFTRinh-172 (CFTR inhibitor 172) is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.

S8094

GlyH-101

GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM.

S0198

PPQ-102

PPQ-102 (CFTR Inhibitor IV) is a potent inhibitor of CFTR. PPQ-102 can completely inhibit CFTR chloride current with IC50 of ~90 nM.

S3272

Steviol (Hydroxydehydrostevic acid)

Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902), a major metabolite of the sweetening compound stevioside, inhibits CFTR activity, reduces AQP2 expression and promotes AQP2 degradation.

Catalog No. Information Product Use Citations Product Validations
S6911

Nesolicaftor (PTI-428)

Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression.

Catalog No. Information Product Use Citations Product Validations
S8795

FDL169

FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.

S8535

Galicaftor (ABBV-2222)

Galicaftor (ABBV-2222, GLPG2222) is a potent corrector of CFTR for the treatment of Cystic Fibrosis (CF).