CFTR
Inhibitory Selectivity
CFTR Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S7139 |
CFTRinh-172CFTRinh-172 (CFTR inhibitor 172) is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. |
CFTR inhibitor CFTR_inh172 leads to PGCs disorder in early zebrafish embryo. Analysis of localization of nanos1/vasa positive cells in embryos by WISH at 50% Epiboly stage with top view.
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| S8094 |
GlyH-101GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM. |
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| S0198 |
PPQ-102PPQ-102 (CFTR Inhibitor IV) is a potent inhibitor of CFTR. PPQ-102 can completely inhibit CFTR chloride current with IC50 of ~90 nM. |
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| S3272 |
Steviol (Hydroxydehydrostevic acid)Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902), a major metabolite of the sweetening compound stevioside, inhibits CFTR activity, reduces AQP2 expression and promotes AQP2 degradation. |
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| S6911 |
Nesolicaftor (PTI-428)Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression. |
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| S8795 |
FDL169FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein. |
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| S8535 |
Galicaftor (ABBV-2222)Galicaftor (ABBV-2222, GLPG2222) is a potent corrector of CFTR for the treatment of Cystic Fibrosis (CF). |
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| S9972New |
Icenticaftor (QBW251)Icenticaftor (QBW251, NVP-QBW251) is an oral potentiator of the cystic fibrosis transmembrane conductance regulator (CFTR) channel with EC50 of 79 nM and 497 nM for F508del CFTR and G551D CFTR in Fisher Rat Thyroid (FRT) cells. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S7139 |
CFTRinh-172CFTRinh-172 (CFTR inhibitor 172) is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. |
CFTR inhibitor CFTR_inh172 leads to PGCs disorder in early zebrafish embryo. Analysis of localization of nanos1/vasa positive cells in embryos by WISH at 50% Epiboly stage with top view.
|
|
| S8094 |
GlyH-101GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM. |
||
| S0198 |
PPQ-102PPQ-102 (CFTR Inhibitor IV) is a potent inhibitor of CFTR. PPQ-102 can completely inhibit CFTR chloride current with IC50 of ~90 nM. |
||
| S3272 |
Steviol (Hydroxydehydrostevic acid)Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902), a major metabolite of the sweetening compound stevioside, inhibits CFTR activity, reduces AQP2 expression and promotes AQP2 degradation. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S6911 |
Nesolicaftor (PTI-428)Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S8795 |
FDL169FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein. |
||
| S8535 |
Galicaftor (ABBV-2222)Galicaftor (ABBV-2222, GLPG2222) is a potent corrector of CFTR for the treatment of Cystic Fibrosis (CF). |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S9972New |
Icenticaftor (QBW251)Icenticaftor (QBW251, NVP-QBW251) is an oral potentiator of the cystic fibrosis transmembrane conductance regulator (CFTR) channel with EC50 of 79 nM and 497 nM for F508del CFTR and G551D CFTR in Fisher Rat Thyroid (FRT) cells. |
