CFTR
Inhibitory Selectivity
CFTR Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S7139 |
CFTRinh-172CFTRinh-172 (CFTR inhibitor 172) is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. |
CFTR inhibitor CFTR_inh172 leads to PGCs disorder in early zebrafish embryo. Analysis of localization of nanos1/vasa positive cells in embryos by WISH at 50% Epiboly stage with top view.
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| S8094 |
GlyH-101GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM. |
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| S0198 |
PPQ-102PPQ-102 (CFTR Inhibitor IV) is a potent inhibitor of CFTR. PPQ-102 can completely inhibit CFTR chloride current with IC50 of ~90 nM. |
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| S3272 |
Steviol (Hydroxydehydrostevic acid)Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902), a major metabolite of the sweetening compound stevioside, inhibits CFTR activity, reduces AQP2 expression and promotes AQP2 degradation. |
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| S6911 |
Nesolicaftor (PTI-428)Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression. |
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| S8795 |
FDL169FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein. |
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| S8535 |
Galicaftor (ABBV-2222)Galicaftor (ABBV-2222, GLPG2222) is a potent corrector of CFTR for the treatment of Cystic Fibrosis (CF). |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S7139 |
CFTRinh-172CFTRinh-172 (CFTR inhibitor 172) is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. |
CFTR inhibitor CFTR_inh172 leads to PGCs disorder in early zebrafish embryo. Analysis of localization of nanos1/vasa positive cells in embryos by WISH at 50% Epiboly stage with top view.
|
|
| S8094 |
GlyH-101GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM. |
||
| S0198 |
PPQ-102PPQ-102 (CFTR Inhibitor IV) is a potent inhibitor of CFTR. PPQ-102 can completely inhibit CFTR chloride current with IC50 of ~90 nM. |
||
| S3272 |
Steviol (Hydroxydehydrostevic acid)Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902), a major metabolite of the sweetening compound stevioside, inhibits CFTR activity, reduces AQP2 expression and promotes AQP2 degradation. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S6911 |
Nesolicaftor (PTI-428)Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S8795 |
FDL169FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein. |
||
| S8535 |
Galicaftor (ABBV-2222)Galicaftor (ABBV-2222, GLPG2222) is a potent corrector of CFTR for the treatment of Cystic Fibrosis (CF). |
