DHFR

Inhibitory Selectivity

DHFR Products

New DHFR Products
Catalog No. Information Product Use Citations Product Validations
S2588New

Calcium Levofolinate

Calcium Levofolinate (Calcium Folinate, Levoleucovorin calcium, CL307782) is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy.

S5971New

Pemetrexed

Pemetrexed (LY231514, Alimta) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.

S0320

Cycloguanil hydrochloride

Cycloguanil hydrochloride is an active metabolite of Proguanil. Cycloguanil hydrochloride acts on malaria schizonts in erythrocytes and hepatocytes.

S0854

Metoprine

Metoprine (BW 197U), a diaminopyrimidine derivative, is a potent inhibitor of histamine N-methyltransferase (HMT) that crosses the blood-brain barrier and increases brain histamine levels. Metoprine is an antifolate and antitumor agent.

Catalog No. Information Product Use Citations Product Validations
S2588New

Calcium Levofolinate

Calcium Levofolinate (Calcium Folinate, Levoleucovorin calcium, CL307782) is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy.

S5971New

Pemetrexed

Pemetrexed (LY231514, Alimta) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.

Catalog No. Information Product Use Citations Product Validations
S0320

Cycloguanil hydrochloride

Cycloguanil hydrochloride is an active metabolite of Proguanil. Cycloguanil hydrochloride acts on malaria schizonts in erythrocytes and hepatocytes.

Catalog No. Information Product Use Citations Product Validations
S0854

Metoprine

Metoprine (BW 197U), a diaminopyrimidine derivative, is a potent inhibitor of histamine N-methyltransferase (HMT) that crosses the blood-brain barrier and increases brain histamine levels. Metoprine is an antifolate and antitumor agent.