GPCR19

Inhibitory Selectivity

GPCR19 Products

New GPCR19 Products
Catalog No. Information Product Use Citations Product Validations
S3069New

Deoxycholic acid sodium salt

Deoxycholic acid sodium salt (Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA) is specifically responsible for activating the TGR5 receptor (GPCR19) that stimulates brown adipose tissue (BAT) thermogenic activity.
S6806

SBI-115

SBI-115 is a novel TGR5 (GPCR19) antagonist. SBI-115 decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.
Research Square, 2021, 10.21203/rs.3.rs-274411/v1
S0034

BAR501

BAR501 is a potent and selective G protein-coupled bile acid receptor 1 (GPBAR1, GPCR19, TGR5) agonist that effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1 with EC50 of 1 μM.
S0193

TGR5 Receptor Agonist

TGR5 Receptor Agonist (TGR5, CCDC, MDK00245, compd 6) is a potent agonist of TGR5(GPCR19, GPBAR1, M-BAR). TGR5 Receptor Agonist shows improved potency with pEC50 of 6.8 and 7.5 in the U2-OS cell assay and in melanophore cells, respectively.
Research Square, 2021, 10.21203/rs.3.rs-274411/v1
S6741

SB-756050

SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).
Catalog No. Information Product Use Citations Product Validations
S3069New

Deoxycholic acid sodium salt

Deoxycholic acid sodium salt (Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA) is specifically responsible for activating the TGR5 receptor (GPCR19) that stimulates brown adipose tissue (BAT) thermogenic activity.
Catalog No. Information Product Use Citations Product Validations
S6806

SBI-115

SBI-115 is a novel TGR5 (GPCR19) antagonist. SBI-115 decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.
Research Square, 2021, 10.21203/rs.3.rs-274411/v1
Catalog No. Information Product Use Citations Product Validations
S0034

BAR501

BAR501 is a potent and selective G protein-coupled bile acid receptor 1 (GPBAR1, GPCR19, TGR5) agonist that effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1 with EC50 of 1 μM.
S0193

TGR5 Receptor Agonist

TGR5 Receptor Agonist (TGR5, CCDC, MDK00245, compd 6) is a potent agonist of TGR5(GPCR19, GPBAR1, M-BAR). TGR5 Receptor Agonist shows improved potency with pEC50 of 6.8 and 7.5 in the U2-OS cell assay and in melanophore cells, respectively.
Research Square, 2021, 10.21203/rs.3.rs-274411/v1
S6741

SB-756050

SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).