GPCR19

Inhibitory Selectivity

GPCR19 Products

Catalog No. Information Product Use Citations Product Validations
S3069

Deoxycholic acid sodium salt

Deoxycholic acid sodium salt (Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA) is specifically responsible for activating the TGR5 receptor (GPCR19) that stimulates brown adipose tissue (BAT) thermogenic activity.
S6806

SBI-115

SBI-115 is a novel TGR5 (GPCR19) antagonist. SBI-115 decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.
Nat Commun, 2022, 13(1):3419
Research Square, 2021, 10.21203/rs.3.rs-274411/v1
S0034

BAR501

BAR501 is a potent and selective G protein-coupled bile acid receptor 1 (GPBAR1, GPCR19, TGR5) agonist that effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1 with EC50 of 1 μM.
S0193

TGR5 Receptor Agonist

TGR5 Receptor Agonist (TGR5, CCDC, MDK00245, compd 6) is a potent agonist of TGR5(GPCR19, GPBAR1, M-BAR). TGR5 Receptor Agonist shows improved potency with pEC50 of 6.8 and 7.5 in the U2-OS cell assay and in melanophore cells, respectively.
Research Square, 2021, 10.21203/rs.3.rs-274411/v1
S6741

SB-756050

SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).
Catalog No. Information Product Use Citations Product Validations
S3069

Deoxycholic acid sodium salt

Deoxycholic acid sodium salt (Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA) is specifically responsible for activating the TGR5 receptor (GPCR19) that stimulates brown adipose tissue (BAT) thermogenic activity.
Catalog No. Information Product Use Citations Product Validations
S6806

SBI-115

SBI-115 is a novel TGR5 (GPCR19) antagonist. SBI-115 decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.
Nat Commun, 2022, 13(1):3419
Research Square, 2021, 10.21203/rs.3.rs-274411/v1
Catalog No. Information Product Use Citations Product Validations
S0034

BAR501

BAR501 is a potent and selective G protein-coupled bile acid receptor 1 (GPBAR1, GPCR19, TGR5) agonist that effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1 with EC50 of 1 μM.
S0193

TGR5 Receptor Agonist

TGR5 Receptor Agonist (TGR5, CCDC, MDK00245, compd 6) is a potent agonist of TGR5(GPCR19, GPBAR1, M-BAR). TGR5 Receptor Agonist shows improved potency with pEC50 of 6.8 and 7.5 in the U2-OS cell assay and in melanophore cells, respectively.
Research Square, 2021, 10.21203/rs.3.rs-274411/v1
S6741

SB-756050

SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).