Lipase

Inhibitory Selectivity

Lipase Products

Catalog No. Information Product Use Citations Product Validations
S4904

JZL184

JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.

S7364

Atglistatin

Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases.

S7457

XEN445

XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.

S9234

Schaftoside

Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.

S6609

JZL195

JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively.

S6550

URB602

URB602 is an inhibitor of monoacylglycerol lipase (MGL), a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG).

S9404

Pristimerin

Pristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon. Pristimerin can inhibits monoacylglycerol lipase(MGL) with an IC50 of 93 nM through a reversible mechanism.

Catalog No. Information Product Use Citations Product Validations
S4904

JZL184

JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.

S7364

Atglistatin

Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases.

S7457

XEN445

XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.

S9234

Schaftoside

Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.

S6609

JZL195

JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively.

S6550

URB602

URB602 is an inhibitor of monoacylglycerol lipase (MGL), a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG).

S9404

Pristimerin

Pristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon. Pristimerin can inhibits monoacylglycerol lipase(MGL) with an IC50 of 93 nM through a reversible mechanism.