MTH1

Inhibitory Selectivity

MTH1 Products

Catalog No. Information Product Use Citations Product Validations
S7631

TH287

TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.

S7632

TH588

TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.

Catalog No. Information Product Use Citations Product Validations
S7631

TH287

TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.

S7632

TH588

TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.