NPY receptor

Inhibitory Selectivity

Isoform-specific Inhibitors

NPY receptor Products

New NPY receptor Products
Catalog No. Information Product Use Citations Product Validations
S0124

CGP71683 hydrochloride

CGP71683 hydrochloride (CGP71683A) is a competitive and sellective neuropeptide Y receptor type 5 (Y5 receptor) antagonist with Ki of 1.3 nM.

S6416

JNJ 31020028

JNJ 31020028 is a novel neuropeptide Y Y2 receptor antagonist which bound with high affinity with human and rat Y2 receptor (pIC50=8.07±0.05 for human Y2 receptor, and pIC50=8.22±0.06 for rat Y2 receptor) and >100-fold selective versus human Y1, Y4, and Y5 receptors.

E0014New

BIBO 3304 Trifluoroacetate

BIBO 3304 Trifluoroacetate (BIBO-3304 TFA) is a novel neuropeptide Y Y1 receptor (NPY1R) antagonist with IC50 values of 0.38 nM and 0.72 nM for human Y1 receptor and rat Y1 receptor, respectively. BIBO 3304 shows low affinity for the human Y2 receptor, human and rat Y4 receptor as well as for the human and rat Y5 receptor (IC50 values >1000 nM).

Catalog No. Information Product Use Citations Product Validations
S0124

CGP71683 hydrochloride

CGP71683 hydrochloride (CGP71683A) is a competitive and sellective neuropeptide Y receptor type 5 (Y5 receptor) antagonist with Ki of 1.3 nM.

S6416

JNJ 31020028

JNJ 31020028 is a novel neuropeptide Y Y2 receptor antagonist which bound with high affinity with human and rat Y2 receptor (pIC50=8.07±0.05 for human Y2 receptor, and pIC50=8.22±0.06 for rat Y2 receptor) and >100-fold selective versus human Y1, Y4, and Y5 receptors.

E0014New

BIBO 3304 Trifluoroacetate

BIBO 3304 Trifluoroacetate (BIBO-3304 TFA) is a novel neuropeptide Y Y1 receptor (NPY1R) antagonist with IC50 values of 0.38 nM and 0.72 nM for human Y1 receptor and rat Y1 receptor, respectively. BIBO 3304 shows low affinity for the human Y2 receptor, human and rat Y4 receptor as well as for the human and rat Y5 receptor (IC50 values >1000 nM).