Opioid Receptor

Inhibitory Selectivity

Isoform-specific Inhibitors

Opioid Receptor Products

New Opioid Receptor Products
Catalog No. Information Product Use Citations Product Validations
S0009

Asimadoline hydrochloride

Asimadoline hydrochloride (EMD-61753 hydrochloride) is an orally active, selective and peripherally active κ-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant).

P1117New

[Leu5]Enkephalin

[Leu5]Enkephalin a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

S2322

(+)-Matrine

Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.

E0013

DAMGO

DAMGO (DAGO) is a potent and selective μ opioid receptor agonist with ki of 17 nM.

P1118New

Dermorphin

Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin, showing inhibition of neuropathic pain.

P1151New

Difelikefalin

Difelikefalin (CR-845, FE-202845), a peripherally restricted and selective agonist of kappa opioid receptor (KOR), produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease.

E0472New

BMS-986122

BMS-986122 is a selective, potent positive allosteric modulator of the mu-opioid receptor (µ-OR), shows potentiation of orthosteric agonist-mediated β-arrestin recruitment, adenylyl cyclase inhibition, and G protein activation, and potentiates DAMGO-mediated [35S]GTPγS binding in mouse brain membranes.

Catalog No. Information Product Use Citations Product Validations
S0009

Asimadoline hydrochloride

Asimadoline hydrochloride (EMD-61753 hydrochloride) is an orally active, selective and peripherally active κ-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant).

P1117New

[Leu5]Enkephalin

[Leu5]Enkephalin a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

S2322

(+)-Matrine

Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.

E0013

DAMGO

DAMGO (DAGO) is a potent and selective μ opioid receptor agonist with ki of 17 nM.

P1118New

Dermorphin

Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin, showing inhibition of neuropathic pain.

P1151New

Difelikefalin

Difelikefalin (CR-845, FE-202845), a peripherally restricted and selective agonist of kappa opioid receptor (KOR), produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease.

Catalog No. Information Product Use Citations Product Validations
E0472New

BMS-986122

BMS-986122 is a selective, potent positive allosteric modulator of the mu-opioid receptor (µ-OR), shows potentiation of orthosteric agonist-mediated β-arrestin recruitment, adenylyl cyclase inhibition, and G protein activation, and potentiates DAMGO-mediated [35S]GTPγS binding in mouse brain membranes.