S1P Receptor

Inhibitory Selectivity

Isoform-specific Inhibitors

S1P Receptor Products

New S1P Receptor Products
Catalog No. Information Product Use Citations Product Validations
S0817

SKI-V

SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.

S7791

Phorbol 12-myristate 13-acetate (PMA)

Phorbol 12-myristate 13-acetate (PMA,12-O-Tetradecanoylphorbol-13-acetate, TPA), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).

S7182

JTE 013

JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.

S6552

CYM5541

CYM5541 (ML249) is a selective, allosteric agonist of S1P3 with an EC50 of between 72 and 132 nM and exhibits exquisite selectivity over other S1P receptor subtypes in vitro: S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM.

S2878New

CYM-5442

CYM-5442 is a potent and selective S1P1 agonist with EC50 of 1.35 nM.

S7180

SEW 2871

SEW 2871 is a highly selective, orally active S1P1 agonist with EC50 of 13.8 nM.

Catalog No. Information Product Use Citations Product Validations
S0817

SKI-V

SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.

Catalog No. Information Product Use Citations Product Validations
S7791

Phorbol 12-myristate 13-acetate (PMA)

Phorbol 12-myristate 13-acetate (PMA,12-O-Tetradecanoylphorbol-13-acetate, TPA), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).

Catalog No. Information Product Use Citations Product Validations
S7182

JTE 013

JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.

Catalog No. Information Product Use Citations Product Validations
S6552

CYM5541

CYM5541 (ML249) is a selective, allosteric agonist of S1P3 with an EC50 of between 72 and 132 nM and exhibits exquisite selectivity over other S1P receptor subtypes in vitro: S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM.

Catalog No. Information Product Use Citations Product Validations
S2878New

CYM-5442

CYM-5442 is a potent and selective S1P1 agonist with EC50 of 1.35 nM.

S7180

SEW 2871

SEW 2871 is a highly selective, orally active S1P1 agonist with EC50 of 13.8 nM.