TOPK

Inhibitory Selectivity

TOPK Products

All (3) TOPK Inhibitors (3)

Catalog No.	Information	Product Use Citations
S7652	OTS514 hydrochloride OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.	Front Pharmacol, 2021, 12:772926 Mol Oncol, 2021, 15(12):3721-3737 Oncogenesis, 2021, 10(1):9
S6882	HI-TOPK-032 HI-TOPK-032 is a potent and specific inhibitor of TOPK. HI-TOPK-032 also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.
S7648	OTS964 OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.	Cell Death Dis, 2022, 13(5):450 Cancer Lett, 2022, 544:215812 Mol Imaging Biol, 2019, 21(4):705-712

Catalog No.

Information

Product Use Citations

Product Validations

S7652

OTS514 hydrochloride

OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.

Front Pharmacol, 2021, 12:772926

Mol Oncol, 2021, 15(12):3721-3737

Oncogenesis, 2021, 10(1):9

S6882

HI-TOPK-032 is a potent and specific inhibitor of TOPK. HI-TOPK-032 also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.

S7648

OTS964

OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.

Cell Death Dis, 2022, 13(5):450

Cancer Lett, 2022, 544:215812

Mol Imaging Biol, 2019, 21(4):705-712

Catalog No.	Information	Product Use Citations
S7652	OTS514 hydrochloride OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.	Front Pharmacol, 2021, 12:772926 Mol Oncol, 2021, 15(12):3721-3737 Oncogenesis, 2021, 10(1):9
S6882	HI-TOPK-032 HI-TOPK-032 is a potent and specific inhibitor of TOPK. HI-TOPK-032 also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.
S7648	OTS964 OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.	Cell Death Dis, 2022, 13(5):450 Cancer Lett, 2022, 544:215812 Mol Imaging Biol, 2019, 21(4):705-712