BACE

Inhibitory Selectivity

BACE Products

New BACE Products
Catalog No. Information Product Use Citations Product Validations
S2156

LY2886721

LY2886721 is a BACE inhibitor used for the treatment of Alzheimer's Disease. Phase 1/2.

S3245

Nodakenetin

Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.

S6503

LX2343

LX2343 is a multi-target agent that exhibits a high capability for ameliorating multi-abnormalities of AD pathogenesis. It is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM.

S3326New

Phytic acid dipotassium salt

Phytic acid dipotassium salt (Phytic acid potassium, IP6 (PS)), an endogenous metabolite in rice grain extract and digest, inhibits β-secretase 1 (BACE1) with IC50 of approximately 0.25 μM.

Catalog No. Information Product Use Citations Product Validations
S2156

LY2886721

LY2886721 is a BACE inhibitor used for the treatment of Alzheimer's Disease. Phase 1/2.

S3245

Nodakenetin

Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.

S6503

LX2343

LX2343 is a multi-target agent that exhibits a high capability for ameliorating multi-abnormalities of AD pathogenesis. It is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM.

S3326New

Phytic acid dipotassium salt

Phytic acid dipotassium salt (Phytic acid potassium, IP6 (PS)), an endogenous metabolite in rice grain extract and digest, inhibits β-secretase 1 (BACE1) with IC50 of approximately 0.25 μM.