Complement System
Inhibitory Selectivity
Complement System Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S3240 |
PhaseoloidinPhaseoloidin, a homogentisic acid glucoside from Nicotiana attenuata trichomes, contributes to the plant's resistance against lepidopteran herbivores. Phaseoloidin has anti-complement effects. |
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| S0803 |
Danicopan (ACH-4471)Danicopan (ACH-4471, ACH-0144471, ACH-CFDIS, ALXN 2040) is a potent, selective and orally active inhibitor of factor D with Kd of 0.54 nM for human Factor D. Danicopan inhibits alternative pathway of complement (APC) activity, and has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). |
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| S8522 |
CompstatinCompstatin binds to complement component C3 and inhibits complement activation with IC50 of 12 μM. |
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| S9138 |
Picfeltarraenin IAPicfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system. |
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| P1209New |
TLQP-21 TFALQP-21 TFA (TLQP-21 Trifluoroacetate) is a VGF-derived peptide that activates the C3aR1 receptor through a folding-upon-binding mechanism. |
||
| S8931 |
SB290157 trifluoroacetateSB290157 trifluoroacetate (SB 290157 TFA) is a potent, competitive and selective antagonist of C3a receptor (C3aR) with IC50 of 200 nM for RBL-C3aR. |
||
| S0525 |
ADH-503 (GB1275)ADH-503 (GB1275, (Z)-Leukadherin-1 choline) is the salt form of leukadherin-1 and acts as a potent allosteric agonist of CD11b. |
||
| S8306 |
Leukadherin-1Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)). |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S3240 |
PhaseoloidinPhaseoloidin, a homogentisic acid glucoside from Nicotiana attenuata trichomes, contributes to the plant's resistance against lepidopteran herbivores. Phaseoloidin has anti-complement effects. |
||
| S0803 |
Danicopan (ACH-4471)Danicopan (ACH-4471, ACH-0144471, ACH-CFDIS, ALXN 2040) is a potent, selective and orally active inhibitor of factor D with Kd of 0.54 nM for human Factor D. Danicopan inhibits alternative pathway of complement (APC) activity, and has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). |
||
| S8522 |
CompstatinCompstatin binds to complement component C3 and inhibits complement activation with IC50 of 12 μM. |
||
| S9138 |
Picfeltarraenin IAPicfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| P1209New |
TLQP-21 TFALQP-21 TFA (TLQP-21 Trifluoroacetate) is a VGF-derived peptide that activates the C3aR1 receptor through a folding-upon-binding mechanism. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S8931 |
SB290157 trifluoroacetateSB290157 trifluoroacetate (SB 290157 TFA) is a potent, competitive and selective antagonist of C3a receptor (C3aR) with IC50 of 200 nM for RBL-C3aR. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S0525 |
ADH-503 (GB1275)ADH-503 (GB1275, (Z)-Leukadherin-1 choline) is the salt form of leukadherin-1 and acts as a potent allosteric agonist of CD11b. |
||
| S8306 |
Leukadherin-1Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)). |
