Complement System
Inhibitory Selectivity
Complement System Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S3240 |
PhaseoloidinPhaseoloidin, a homogentisic acid glucoside from Nicotiana attenuata trichomes, contributes to the plant's resistance against lepidopteran herbivores. Phaseoloidin has anti-complement effects. |
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| S0803 |
Danicopan (ACH-4471)Danicopan (ACH-4471, ACH-0144471, ACH-CFDIS, ALXN 2040) is a potent, selective and orally active inhibitor of factor D with Kd of 0.54 nM for human Factor D. Danicopan inhibits alternative pathway of complement (APC) activity, and has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). |
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| S8522 |
CompstatinCompstatin binds to complement component C3 and inhibits complement activation with IC50 of 12 μM. |
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| S9138 |
Picfeltarraenin IAPicfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system. |
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| S8931 |
SB290157 trifluoroacetateSB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor with IC50 of 200 nM. |
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| S0525 |
ADH-503ADH-503 ((Z)-Leukadherin-1 choline) is an orally active and allosteric agonist of CD11b. ADH-503 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses. |
||
| S8306 |
Leukadherin-1Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)). |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S3240 |
PhaseoloidinPhaseoloidin, a homogentisic acid glucoside from Nicotiana attenuata trichomes, contributes to the plant's resistance against lepidopteran herbivores. Phaseoloidin has anti-complement effects. |
||
| S0803 |
Danicopan (ACH-4471)Danicopan (ACH-4471, ACH-0144471, ACH-CFDIS, ALXN 2040) is a potent, selective and orally active inhibitor of factor D with Kd of 0.54 nM for human Factor D. Danicopan inhibits alternative pathway of complement (APC) activity, and has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). |
||
| S8522 |
CompstatinCompstatin binds to complement component C3 and inhibits complement activation with IC50 of 12 μM. |
||
| S9138 |
Picfeltarraenin IAPicfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S8931 |
SB290157 trifluoroacetateSB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor with IC50 of 200 nM. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S0525 |
ADH-503ADH-503 ((Z)-Leukadherin-1 choline) is an orally active and allosteric agonist of CD11b. ADH-503 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses. |
||
| S8306 |
Leukadherin-1Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)). |
