CRM1

Inhibitory Selectivity

CRM1 Products

Catalog No. Information Product Use Citations Product Validations
S7125

KPT-185

KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.

S7251

KPT-276

KPT-276 is an orally bioavailable selective CRM1 inhibitor.

S7551

Piperlongumine

Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.

Catalog No. Information Product Use Citations Product Validations
S7125

KPT-185

KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.

S7251

KPT-276

KPT-276 is an orally bioavailable selective CRM1 inhibitor.

S7551

Piperlongumine

Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.