CRM1
Inhibitory Selectivity
CRM1 Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S7125 |
KPT-185KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM. |
(D)Western blot analysis of RNF146 in cytoplasmic and nuclear fraction after KPT-185 treatment. Data represented mean ± s.e.m., n = 5; *P < 0.05, **P < 0.01. NES, nuclear export signal. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
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| S7251 |
KPT-276KPT-276 is an orally bioavailable selective CRM1 inhibitor. |
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| S7580 |
Leptomycin BLeptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM–10 nM. |
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| S7551 |
PiperlonguminePiperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells. |
a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. *P < 0.05; **P < 0.01; ***P < 0.001.
|
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S7125 |
KPT-185KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM. |
(D)Western blot analysis of RNF146 in cytoplasmic and nuclear fraction after KPT-185 treatment. Data represented mean ± s.e.m., n = 5; *P < 0.05, **P < 0.01. NES, nuclear export signal. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
|
|
| S7251 |
KPT-276KPT-276 is an orally bioavailable selective CRM1 inhibitor. |
||
| S7580 |
Leptomycin BLeptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM–10 nM. |
||
| S7551 |
PiperlonguminePiperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells. |
a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. *P < 0.05; **P < 0.01; ***P < 0.001.
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