FKBP
Inhibitory Selectivity
Isoform-specific Inhibitors
FKBP Products
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S0713 |
S107 hydrochlorideS107 hydrochloride is a specific stabilizer of RyR2 (type 2 ryanodine receptor)/FKBP12.6 (FK506 binding protein 12.6) complex that affects Ca2+ signaling. |
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S3469 |
Shield-1Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP). Shield-1 reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 stabilizes the entire fusion protein. |
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S9726New |
Rimiducid (AP1903)Rimiducid (AP1903) is a chemical protein dimerizer and binds tightly to the target FKBP fusion protein while binding minimally to the abundant natural FKBP. Rimiducid elicites potent and dose-dependent apoptosis of cells in culture expressing dimerizer-dependent Fas constructs, with an EC50 of ≈0.1 nM. |
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S8487New |
AP20187AP20187 (B/B Homodimerizer) is a chemical inducer of dimerization that activates FKBP-Casp8. |
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S0713 |
S107 hydrochlorideS107 hydrochloride is a specific stabilizer of RyR2 (type 2 ryanodine receptor)/FKBP12.6 (FK506 binding protein 12.6) complex that affects Ca2+ signaling. |
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S3469 |
Shield-1Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP). Shield-1 reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 stabilizes the entire fusion protein. |
||
S9726New |
Rimiducid (AP1903)Rimiducid (AP1903) is a chemical protein dimerizer and binds tightly to the target FKBP fusion protein while binding minimally to the abundant natural FKBP. Rimiducid elicites potent and dose-dependent apoptosis of cells in culture expressing dimerizer-dependent Fas constructs, with an EC50 of ≈0.1 nM. |
||
S8487New |
AP20187AP20187 (B/B Homodimerizer) is a chemical inducer of dimerization that activates FKBP-Casp8. |