Histamine Receptor
Inhibitory Selectivity
Isoform-specific Inhibitors
Histamine Receptor Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S3913 |
Pimethixene maleatePimethixene (Pimetixene) maleate, an antihistamine, anntimigraine agent and antiserotonergic compound, is a highly potent antagonist of a broad range of monoamine receptors, including a variety of serotonin receptors. Pimethixene maleate inhibits 5-HT2A, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1B, 5-HT6, 5-HT7, Adrenergic α-1A, Dopamine D1 Receptor, Dopamine D2 Receptor, Dopamine D4.4 Receptor, Histamine H1 Receptor, Muscarinic M1 and Muscarinic M2 with pKi of 10.22, 10.44, 8.42, 7.63, < 5, 7.30, 7.28, 7.61, 6.37, 8.19, 7.54, 10.14, 8.61 and 9.38, respectively. |
||
| S6835New |
3-deazaadenosine3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM, and has anti-inflammatory, anti-proliferative and anti-HIV activity. |
||
| S2308 |
HesperetinHesperetin is a bioflavonoid and, to be more specific, a flavanone. |
||
| S5864 |
LevocetirizineLevocetirizine (LCZ, (R)-Cetirizine), the R-enantiomer of cetirizine, is an antagonist of histamine H(1) receptor. |
||
| E0164New |
Antazoline PhosphateAntazoline Phosphate is the phosphate salt of antazoline. Antazoline is a first-generation antihistaminic agent and acts as a histamine H1 receptor antagonist. |
||
| S5196 |
PromethazinePromethazine is a potent histamine H1 receptor antagonist. Promethazine is a medication used in the management and treatment of allergic conditions, nausea and vomiting, motion sickness, and sedation. Promethazine exhibits antiparasitic properties. |
||
| S0398 |
AstemizoleAstemizole (R 43512) is a histamine H1-receptor antagonist with IC50 of 4.7 nM. Astemizole is also a potent inhibitor of ether à-go-go 1 (Eag1) and Eag-related gene (Erg) potassium channels. Astemizole has antineoplastic and antipruritic effects. |
||
| S0897 |
CyclizineCyclizine is a piperazine first-generation antagonist of histamine 1 receptor. |
||
| S6569 |
VUF10460VUF10460 is a histamine H4 receptor agonist. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S3913 |
Pimethixene maleatePimethixene (Pimetixene) maleate, an antihistamine, anntimigraine agent and antiserotonergic compound, is a highly potent antagonist of a broad range of monoamine receptors, including a variety of serotonin receptors. Pimethixene maleate inhibits 5-HT2A, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1B, 5-HT6, 5-HT7, Adrenergic α-1A, Dopamine D1 Receptor, Dopamine D2 Receptor, Dopamine D4.4 Receptor, Histamine H1 Receptor, Muscarinic M1 and Muscarinic M2 with pKi of 10.22, 10.44, 8.42, 7.63, < 5, 7.30, 7.28, 7.61, 6.37, 8.19, 7.54, 10.14, 8.61 and 9.38, respectively. |
||
| S6835New |
3-deazaadenosine3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM, and has anti-inflammatory, anti-proliferative and anti-HIV activity. |
||
| S2308 |
HesperetinHesperetin is a bioflavonoid and, to be more specific, a flavanone. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S5864 |
LevocetirizineLevocetirizine (LCZ, (R)-Cetirizine), the R-enantiomer of cetirizine, is an antagonist of histamine H(1) receptor. |
||
| E0164New |
Antazoline PhosphateAntazoline Phosphate is the phosphate salt of antazoline. Antazoline is a first-generation antihistaminic agent and acts as a histamine H1 receptor antagonist. |
||
| S5196 |
PromethazinePromethazine is a potent histamine H1 receptor antagonist. Promethazine is a medication used in the management and treatment of allergic conditions, nausea and vomiting, motion sickness, and sedation. Promethazine exhibits antiparasitic properties. |
||
| S0398 |
AstemizoleAstemizole (R 43512) is a histamine H1-receptor antagonist with IC50 of 4.7 nM. Astemizole is also a potent inhibitor of ether à-go-go 1 (Eag1) and Eag-related gene (Erg) potassium channels. Astemizole has antineoplastic and antipruritic effects. |
||
| S0897 |
CyclizineCyclizine is a piperazine first-generation antagonist of histamine 1 receptor. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S6569 |
VUF10460VUF10460 is a histamine H4 receptor agonist. |
