Integrin
Inhibitory Selectivity
Integrin Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| A2045New |
Vedolizumab (anti-α4β7-integrin)Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease. |
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| S8008 |
RGD (Arg-Gly-Asp) PeptidesRGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins. |
Observation of actin cytoskeleton and nucleus of MC3T3-E1 cells cultured in the presence of different inhibitors (Control, EDTA, RGD, MAB1998, IgG and Heparin) after 24 hours of incubation.
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| S2885 |
A-205804A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively. |
The effect of rhICAM-1 or inhibitor A-205804 on hepsin or CtsD transfected MCF-7 cells was detected. The level of E-cadherin, claudin-1, N-cadherin, vimentin and Snail1 was analyzed by western blot.
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| S7540 |
SB273005SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively. |
Western blot analysis of levels of p-FAK (Tyr397) and total FAK in SK-N-SH cells treated with SB273005 (3 μM) for 6 h and 24 h. One experiment is shown for each cell line. Control cells (treated with diluent, marked as C, were also included). α-tubulin was used as the reference protein.
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| S6387New |
CilengitideCilengitide (EMD 121974, EMD-12192, EMD-85189, NSC-707544) is a potent and selective inhibitor of the integrins ανβ3 and ανβ5 with IC50 of 4 and 79 nM, respectively. |
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| S4513 |
RGD peptide (GRGDNP)RGD peptide (GRGDNP) is an inhibitor of binding of integrins to the extracellular matrixs. RGD peptide (GRGDNP) induces apoptosis presumably through direct activation of caspase-3. |
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| S6840 |
OSU-T315OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity. |
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| S7834 |
Cyclo (-RGDfK)Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor. |
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| S0314 |
TR-14035TR-14035 (SB 683698, MDK-1191) is a a dual alpha4beta (α4β) integrin antagonist with IC50 of 7 nM and 87 nM for alpha4beta7 (α4β7) and alpha4beta1 (α4β1), respectively. |
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| S8306 |
Leukadherin-1Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)). |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| A2045New |
Vedolizumab (anti-α4β7-integrin)Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease. |
||
| S8008 |
RGD (Arg-Gly-Asp) PeptidesRGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins. |
Observation of actin cytoskeleton and nucleus of MC3T3-E1 cells cultured in the presence of different inhibitors (Control, EDTA, RGD, MAB1998, IgG and Heparin) after 24 hours of incubation.
|
|
| S2885 |
A-205804A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively. |
The effect of rhICAM-1 or inhibitor A-205804 on hepsin or CtsD transfected MCF-7 cells was detected. The level of E-cadherin, claudin-1, N-cadherin, vimentin and Snail1 was analyzed by western blot.
|
|
| S7540 |
SB273005SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively. |
Western blot analysis of levels of p-FAK (Tyr397) and total FAK in SK-N-SH cells treated with SB273005 (3 μM) for 6 h and 24 h. One experiment is shown for each cell line. Control cells (treated with diluent, marked as C, were also included). α-tubulin was used as the reference protein.
|
|
| S6387New |
CilengitideCilengitide (EMD 121974, EMD-12192, EMD-85189, NSC-707544) is a potent and selective inhibitor of the integrins ανβ3 and ανβ5 with IC50 of 4 and 79 nM, respectively. |
||
| S4513 |
RGD peptide (GRGDNP)RGD peptide (GRGDNP) is an inhibitor of binding of integrins to the extracellular matrixs. RGD peptide (GRGDNP) induces apoptosis presumably through direct activation of caspase-3. |
||
| S6840 |
OSU-T315OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity. |
||
| S7834 |
Cyclo (-RGDfK)Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S0314 |
TR-14035TR-14035 (SB 683698, MDK-1191) is a a dual alpha4beta (α4β) integrin antagonist with IC50 of 7 nM and 87 nM for alpha4beta7 (α4β7) and alpha4beta1 (α4β1), respectively. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S8306 |
Leukadherin-1Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)). |
