IRAK
Inhibitory Selectivity
Isoform-specific Inhibitors
IRAK Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S0008 |
IRAK4-IN-1IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with IC50 of 7 nM. |
||
| S8562 |
IRAK4-IN-2IRAK4-IN-2 is a reversible kinase inhibitor that modulates IRAK4 function in both the toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) signaling cascades. |
||
| S9779New |
Emavusertib (CA-4948)Emavusertib (CA-4948) is a potent and orally bioavailable inhibitor of interleukin-1 receptor-associated kinase 4/FMS-like Tyrosine Kinase 3 (IRAK4/FLT3) with anti-tumor activity. |
||
| S0775 |
IRAK4-IN-4IRAK4-IN-4 (compound 15) is an inhibitor of interleukin-1 receptor–associated kinase 4 (IRAK4) and cyclic GMP-AMP synthase (cGAS) with IC50 of 2.8 nM and 2.1 nM, respectively. |
||
| S9780New |
JH-X-119-01JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK1 with IC50 of 9 nM. |
||
| S9701New |
HS-243HS-243 is a highly potent interleukin-1 receptor-associated kinase (IRAK) inhibitor with IC50 of 24 nM, 20 nM and 0.5 μM for IRAK-1, IRAK-4 and TAK1, respectively. |
||
| S2039 |
IRAK inhibitor 6IRAK inhibitor 6 is a selective Interleukin-1 receptor-associated kinase 4(IRAK4) inhibitor with IC50 of 0.16 μM. |
||
| S8696 |
2-D082-D08 (2',3',4'-trihydroxy flavone) is a cell permeable, mechanistically unique inhibitor of protein sumoylation. It is also inhibits Axl, IRAK4, ROS1, MLK4, GSK3β, RET (c-RET), KDR and PI3Kα with IC50 values of 0.49, 3.9, 5.3, 9.8, 11, 11, 17 and 35 nM respectively in biochemical assays. |
||
| S8531 |
PF-06650833PF-06650833 is a potent, selective inhibitor of IRAK4 with an IC50 of 0.2 nM. |
||
| S6598 |
IRAK-1-4 Inhibitor IIRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor associated kinase (IRAK) with IC50 values of 0.3 μM and 0.2 μM for IRAK-1 and IRAK-4, respectively. It displays IC50 values >10 µM in a panel of 27 other kinases tested. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S0008 |
IRAK4-IN-1IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with IC50 of 7 nM. |
||
| S8562 |
IRAK4-IN-2IRAK4-IN-2 is a reversible kinase inhibitor that modulates IRAK4 function in both the toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) signaling cascades. |
||
| S9779New |
Emavusertib (CA-4948)Emavusertib (CA-4948) is a potent and orally bioavailable inhibitor of interleukin-1 receptor-associated kinase 4/FMS-like Tyrosine Kinase 3 (IRAK4/FLT3) with anti-tumor activity. |
||
| S0775 |
IRAK4-IN-4IRAK4-IN-4 (compound 15) is an inhibitor of interleukin-1 receptor–associated kinase 4 (IRAK4) and cyclic GMP-AMP synthase (cGAS) with IC50 of 2.8 nM and 2.1 nM, respectively. |
||
| S9780New |
JH-X-119-01JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK1 with IC50 of 9 nM. |
||
| S9701New |
HS-243HS-243 is a highly potent interleukin-1 receptor-associated kinase (IRAK) inhibitor with IC50 of 24 nM, 20 nM and 0.5 μM for IRAK-1, IRAK-4 and TAK1, respectively. |
||
| S2039 |
IRAK inhibitor 6IRAK inhibitor 6 is a selective Interleukin-1 receptor-associated kinase 4(IRAK4) inhibitor with IC50 of 0.16 μM. |
||
| S8696 |
2-D082-D08 (2',3',4'-trihydroxy flavone) is a cell permeable, mechanistically unique inhibitor of protein sumoylation. It is also inhibits Axl, IRAK4, ROS1, MLK4, GSK3β, RET (c-RET), KDR and PI3Kα with IC50 values of 0.49, 3.9, 5.3, 9.8, 11, 11, 17 and 35 nM respectively in biochemical assays. |
||
| S8531 |
PF-06650833PF-06650833 is a potent, selective inhibitor of IRAK4 with an IC50 of 0.2 nM. |
||
| S6598 |
IRAK-1-4 Inhibitor IIRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor associated kinase (IRAK) with IC50 values of 0.3 μM and 0.2 μM for IRAK-1 and IRAK-4, respectively. It displays IC50 values >10 µM in a panel of 27 other kinases tested. |
