GluR
Inhibitory Selectivity
Isoform-specific Inhibitors
GluR Products
Catalog No. | Information | Product Use Citations | Product Validations |
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S2860 |
IEM 1754 2HBrIEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM. |
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S6906 |
Capric acidCapric acid (DA, Decanoic acid, Decylic acid), a component of medium-chain triclycerides occurring naturally in coconut oil and palm kernel oil, contributes to seizure control through direct AMPA receptor inhibition. Capric acid is also a modulating ligand for PPARs. Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt. |
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S4774 |
Xanthurenic AcidXanthurenic acid (xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3). |
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S9686 |
NBQX (FG9202)NBQX (FG9202, NNC 079202) is a highly selective and competitive antagonist of AMPA receptor (AMPAR) with anti-epileptic effect. |
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S2645 |
SIB 1757SIB 1757 is a highly selective, noncompetitive antagonist of metabotropic glutamate receptor type 5 (mGluR5) with IC50 of 0.4 μM at hmGluR5 compared with >30 µM at hmGluR1b, hmGluR2, hmGluR4, hmGluR6, hmGluR7 and hmGluR8. |
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S2795 |
VU 0357121VU0357121 is a novel positive allosteric modulator (PAM) of mGlu5 with EC50 of 33 nM, is inactive or very weakly antagonizing at other mGlu receptor subtypes. |
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S8035 |
VU 0364439VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM. |
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S5137 |
O-Phospho-L-serineO-Phospho-L-serine (Dexfosfoserine), a molecule that mimics the phosphatidylserine head group and partially blocks microglial phagocytosis of apoptotic cells, is a specific group III metabotropic glutamate receptor (mGluR) agonist. |
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S0165 |
Ampalex (CX-516)Ampalex (CX-516, Ampakine CX 516, BDP-12, SPD 420) is a positive allosteric modulator of AMPA receptor. Ampalex exhibits potential treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). |
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S2862 |
VU 0364770VU 0364770 is a positive allosteric modulator(PAM) of mGlu4 with EC50 of 1.1 μM, exhibits insignificant activity at 68 other receptors, including other mGlu subtypes. |
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S2892 |
VU 0361737VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors, can penetrate into CNS. |
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S6803 |
1-BCP1-BCP (Piperonylic acid piperidide) is a memory-enhancing agent that enhances AMPA-induced currents. |
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S6804 |
CX546CX546, a prototypical ampakine agent, is a selective positive AMPA receptor modulator. |
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S6618 |
JNJ-42153605JNJ-42153605 is a potent and selective mGlu2 receptor positive allosteric modulator with an EC50 of 17 nM. |
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S2434 |
IDRA-21IDRA-21 is a partial allosteric modulator of AMPA receptor desensitization. IDRA-21 is a potent cognition-enhancing drug virtually devoid of neurotoxic liability. |
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S1893 |
D-glutamineD-glutamine is a D type stereoisomer of glutamine which is one of the 20 amino acids encoded by the standard genetic code. |
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S2860 |
IEM 1754 2HBrIEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM. |
||
S6906 |
Capric acidCapric acid (DA, Decanoic acid, Decylic acid), a component of medium-chain triclycerides occurring naturally in coconut oil and palm kernel oil, contributes to seizure control through direct AMPA receptor inhibition. Capric acid is also a modulating ligand for PPARs. Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt. |
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S4774 |
Xanthurenic AcidXanthurenic acid (xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3). |
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S9686 |
NBQX (FG9202)NBQX (FG9202, NNC 079202) is a highly selective and competitive antagonist of AMPA receptor (AMPAR) with anti-epileptic effect. |
||
S2645 |
SIB 1757SIB 1757 is a highly selective, noncompetitive antagonist of metabotropic glutamate receptor type 5 (mGluR5) with IC50 of 0.4 μM at hmGluR5 compared with >30 µM at hmGluR1b, hmGluR2, hmGluR4, hmGluR6, hmGluR7 and hmGluR8. |
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S2795 |
VU 0357121VU0357121 is a novel positive allosteric modulator (PAM) of mGlu5 with EC50 of 33 nM, is inactive or very weakly antagonizing at other mGlu receptor subtypes. |
||
S8035 |
VU 0364439VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM. |
||
S5137 |
O-Phospho-L-serineO-Phospho-L-serine (Dexfosfoserine), a molecule that mimics the phosphatidylserine head group and partially blocks microglial phagocytosis of apoptotic cells, is a specific group III metabotropic glutamate receptor (mGluR) agonist. |
||
S0165 |
Ampalex (CX-516)Ampalex (CX-516, Ampakine CX 516, BDP-12, SPD 420) is a positive allosteric modulator of AMPA receptor. Ampalex exhibits potential treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). |
||
S2862 |
VU 0364770VU 0364770 is a positive allosteric modulator(PAM) of mGlu4 with EC50 of 1.1 μM, exhibits insignificant activity at 68 other receptors, including other mGlu subtypes. |
||
S2892 |
VU 0361737VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors, can penetrate into CNS. |
||
S6803 |
1-BCP1-BCP (Piperonylic acid piperidide) is a memory-enhancing agent that enhances AMPA-induced currents. |
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S6804 |
CX546CX546, a prototypical ampakine agent, is a selective positive AMPA receptor modulator. |
||
S6618 |
JNJ-42153605JNJ-42153605 is a potent and selective mGlu2 receptor positive allosteric modulator with an EC50 of 17 nM. |
||
S2434 |
IDRA-21IDRA-21 is a partial allosteric modulator of AMPA receptor desensitization. IDRA-21 is a potent cognition-enhancing drug virtually devoid of neurotoxic liability. |
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S1893 |
D-glutamineD-glutamine is a D type stereoisomer of glutamine which is one of the 20 amino acids encoded by the standard genetic code. |