MALT Inhibition | MALT Inhibitors Review

Inhibitory Selectivity

Isoform-specific Inhibitors

MALT1 Selective

MALT Products

All (3) MALT Inhibitors (3) New MALT Products

Catalog No.	Information	Product Use Citations	Product Validations
S8898	MLT-748 MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state.
S7429	MI-2 (MALT1 inhibitor) MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor with IC50 of 5.84 μM.	Blood Adv, 2020, 4(5):819-829 Cell Metab, 2019, 29(5):1166-1181 Mol Carcinog, 2019, 58(12):2340-2352	(a-b) Cell growth analysis via MTT assay. Melanoma cell lines, including A2028, A375, WM35, Skmel28, CRL7625 and CRL7626, were seeded in 96-well dishes, and treated in tetrads for 48 hours with varying doses of MI-2. Graph represents average percent of live cells normalized to the untreated group +/- SD.
S9896^New	JNJ-67856633 JNJ-67856633 (JNJ-6633) is a potent, selective, allosteric inhibitor of MALT1 protease.

Catalog No.

Information

Product Use Citations

Product Validations

S8898

MLT-748

MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state.

S7429

MI-2 (MALT1 inhibitor)

MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor with IC50 of 5.84 μM.

Blood Adv, 2020, 4(5):819-829

Cell Metab, 2019, 29(5):1166-1181

Mol Carcinog, 2019, 58(12):2340-2352

S9896^New

JNJ-67856633

JNJ-67856633 (JNJ-6633) is a potent, selective, allosteric inhibitor of MALT1 protease.

Catalog No.	Information	Product Use Citations	Product Validations
S8898	MLT-748 MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state.
S7429	MI-2 (MALT1 inhibitor) MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor with IC50 of 5.84 μM.	Blood Adv, 2020, 4(5):819-829 Cell Metab, 2019, 29(5):1166-1181 Mol Carcinog, 2019, 58(12):2340-2352	(a-b) Cell growth analysis via MTT assay. Melanoma cell lines, including A2028, A375, WM35, Skmel28, CRL7625 and CRL7626, were seeded in 96-well dishes, and treated in tetrads for 48 hours with varying doses of MI-2. Graph represents average percent of live cells normalized to the untreated group +/- SD.
S9896^New	JNJ-67856633 JNJ-67856633 (JNJ-6633) is a potent, selective, allosteric inhibitor of MALT1 protease.