|Catalog No.||Product Name||Information|
|S3243||Zeaxanthin||Zeaxanthin, the carotenoid alcohol participates in the xanthophyll cycle, activates the extrinsic apoptosis pathway which induces apoptosis on uveal melanoma cells with IC50 value 40.8 µM.|
|E3540||Grapefruit Extract||Grapefruit Extract is an extract of Citrus paradisi which can be used for anti-inflammatory, immune and other research.|
|E3319||Grifola frondosa Extract||Grifola frondosa Extract is an extract of Grifola frondosa, which can be used in researches of tumors and metabolism.|
|E2748||EGCG Octaacetate||EGCG Octaacetate(AcEGCG) is a pro-drug of epigallocatechin-3-gallate (EGCG). EGCG have potent anti-oxidative, anti-mitotic and anti-angiogenic properties.|
|E2438||Ginsenoside Rg3||Ginsenoside Rg3 is a ginsenoside found in Panax japonicus var. and Panax ginseng, mainly used for the study of tumor diseases.|
|E3570||Artemisia annua Extract||Artemisia annua Extract is extracts from artemisia annua, which have antiviral activity.|
|E0657||Rubiadin 1-methyl ether||Rubiadin-1-methyl ether, a natural anthraquinone compound isolated from the root of Morinda officinalis How, can inhibit osteoclastic bone resorption through blocking NF-κB pathway and may be a promising agent for the prevention and treatment of bone diseases characterized by excessive bone resorption.|
|E2693||Phycocyanobilin||Phycocyanobilin (PCB) is an open-chain tetrapyrrole chromophore covalently bonded to both polypeptide chains of C-Phycocyanin (C-PC), the most represented biliprotein of Spirulina platensis, the mechanisms by which it protected cells included the reduction of oxidative stress damage, which could contribute to its clinical efficacy for the treatment of neurodegenerative diseases.|
|S8989||Xanthatin||Xanthatin is a sesquiterpene lactone isolated from Xanthium strumarium leaves, which can inhibit the nuclear factor kappa-B (NF-κB), mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STATs) signaling pathways.|
|E0599||Arecaidine hydrochloride||Arecaidine hydrochloride, a constituent of the nut of Areca catechu, inhibits the uptake of GABA and beta-alanine, but not that of glycine.|
|S0563||10-Deacetyl-7-xylosyl paclitaxel||10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel), a derivative of paclitaxel and naturally occurring xyloside isolated from Taxus chinensis, causes significant mitotic arrest in PC-3 cells followed by up-regulating expression of pro-apoptotic Bax and Bad protein, as well as down-regulating expression of anti-apoptotic Bcl-2 and Bcl-XL , which leads to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9.|
|E3387||Sophora flavescens Extract||Sophora flavescens Extract (Sophora angustifolia root Extract) is extracted from Chinese traditional herb Kushen (Sophora flavescens Aiton).|
|E1138||CQ31||CQ31, a small molecule, selectively activates caspase activation and recruitment domain-containing 8 (CARD8).|
|E3682||Pseudostellaria heterophylla Extract||Pseudostellaria heterophylla Extract(Radix Pseudostellaria Extract) is an active ingredient extracted from Pseudostellaria heterophylla, which can be used in the treatment of diabetes.|
|E0769||Ginsenoside Rh4||Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.|
|E2683||Ursodeoxycholic acid sodium||Ursodeoxycholic acid sodium is a sodium salt of a naturally occurring bile acid that is used to treat a variety of hepatic and gastrointestinal diseases.|
|E0671||Deacetylasperulosidic acid||Deacetylasperulosidic acid, a major phytochemical constituent of Morinda citrifolia fruit, has antioxidant activity by increasing superoxide dismutase (SOD) activity, as well as anticlastogenic activity by suppressing the induction of chromosome aberrations in Chinese hamster ovary cells and mice.|
|S8233||Prodigiosin||Prodigiosin is a natural red pigment produced by numerous bacterial species which can inhibit Wnt/β-catenin pathway.|
|S6975||N-Vanillyldecanamide||N-Vanillyldecanamide is a capsaicinoid isolated from the fruits of Capsicum annuum, which can significantly reduce the radical length of Lactuca sativa seedling in a dose-dependent manner.|
|E3199||Petasites Japonicus Extract||Petasites Japonicus Extract regulates osteoblast differentiation at least in part through Runt-related transcriptional factor 2 (RUNX2) and Osterix, suggesting an aqueous extract of P. japonicus leaves is likely to be useful as an alternative therapeutic for preventing and treating osteoporosis.|
Silydianin is an active constituent of <i>Silybium marianum</i>, with exhibit anti-collagenase, antitumor and anti-elastase activities.
|E2548||N-(p-Coumaroyl) Serotonin||N-(p-Coumaroyl) Serotonin (p-coumaroylserotonin) is a polyphenol isolated from the seeds of safflower and has antioxidative, anti-atherogenic and anti-inflammatory properties, can inhibits PDGF-induced on phosphorylation of PDGF receptor and Ca2+ release from sarcoplasmic reticulum.|
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor.
|E0477||N-Caffeoyl O-methyltyramine||N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.|
|E2833||1,5-Anhydro-D-glucitol||1,5-Anhydro-D-glucitol (1,5-Anhydroglucitol, 1,5-AG) is a naturally occurring monosaccharide found in nearly all foods, supporting reliable evidences for early forecast and screening of diabetes mellitus.|
|E2354||Valepotriate||Valepotriate, an unstable iridoid isolated from Valeriana jatamansi Jones, has anti-epileptic by significantly increasing the expression of GABAA, glutamic acid decarboxylase 65, and Bcl-2 and reduce the expression of caspase-3.|
|E2641||trans-Chalcone||Trans-Chalcone, the backbone of flavonoids, also is a potent fatty acid synthase (FAS) with IC50 of 17.1 μg/mL, and α-amylase inhibitor, causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7, exerting antifungal and anticancer activities.|
|E0738||Gipsoside||Gypenoside is a triterpene saponin from gypsophila paniculata L.|
|E0831||Pseudocoptisine chloride||Pseudocoptisine chloride (Isocoptisine chloride) is a quaternary alkaloid with benzylisoquinoline skeleton isolated from Corydalis Tuber, inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM, showing anti-inflammatory and anti-amnestic effects.|
|E3505||Hibiscus syriacus flower Extract|
|E3503||Papaya Leaf Extract|
|E3684||Semen Persicae Extract|
|E3685||Ampelopsis grossedentata Extract|
|E3686||60% Garcinia cambogia Extract|
|E3687||Radix Actinidiae Extract|
|E3725||Sapindus saponaria Linnaeus nutshell Extract (40%)|
|E3726||Sapindus saponaria Linnaeus nutshell Extract (70%)|
|E3727||Daphne genkwa Sieb.et Zucc. Extract|
|E3728||Brassica rapa Extract|
|E3729||Ulmus macrocarpa Hance seeds Extract|
|E3730||Tetradium ruticarpum fruits Extract|
|E3731||Chinese Gallnut Extract|
|E3732||Cortex Acanthopanacis Senticosus Extract|
|E3733||Faeces Trogopterori Extract|
|E3734||Schisandrae Chinensis fructus Extract||
Schisandrae Chinensis fructus Extract is extracted from Schisandra chinensis Fructus, the dry ripe fruit of <i>Schisandra chinensis</i> (Turcz.) Baill.. Schisandrae Chinensis fructus is mainly used for the treatment of dysphoria and palpitation, insomnia. Schisandrae Chinensis fructus and its active ingredients show a protective role in Neurological diseases, including cerebrovascular diseases, neurodegenerative diseases, or depression.
|E3735||Ficus hirta Vahl Extract|
|E3736||Gymnema sylvestre Extract|
|E3752||Abrus precatorius Bean Extract|
|E3778||Magnoliae Flos Extract|
|E3822||Coix Lacryma-Jobi Seed Extract||Coix lacryma-jobi seed Extract is extracted from Coix lacryma-jobi L.. Coix lacryma-jobi seed has anti-inflammatory activity, hypoglycemic activity, the ability to decrease the amount of lipid components in the serum and hypocholesterolemic activity.|
|E3837||Citrus Maxima Peel Extract|
|E3647||Pyrrosiae Folium Extract|
|E3041||Alpiniae Katsumadai Extract|
|E3063||Pygeum Topengii Bark Extract|
|E3129||Garlic Extract (1%)|
|E3289||Knoxia Valerianoides Extract|
|E3365||Weigela Grandiflora Fortune Extract|
|E3392||Balsam Pear Extract|
|E3458||Ilex Paraguariensis Extract|
|E3507||Rose-of-Sharon Seed Extract|
|E3521||Auricledleaf Swallowwort Root Extract|
|E3544||Cattail Pollen Extract|
|E3759||Periploca Sepium Extract|
|E3764||Rose Pelargonium Leaf Extract|
|E3847||Fructus Akebiae Extract|
|E3522||Achyranthes bidentata root Extract|
|E3523||Antrodia cinnamomea Extract|
|E3525||Origanum vulgare leaf Extract|
|E3526||Clematis apiifolia Extract|
|E3527||Glossy privet fruit Extract|
|E3529||Achillea millefolium Extract|
|E3530||Boat-fruited sterculia seed Extract|
|E3533||Loquat leaf Extract|
|E3535||Japanese ardisia Extract|
|E3536||Pleurotus ostreatus Extract|
|E3537||Apple cider vinegar Extract|
|E3539||Grape skin Extract|
|E3541||Grapefruit Seed Extract|
|E3545||Pu-erh tea Extract|
|E3547||Extract of Scandent Schefflera Stem and Leaf|
|E3548||Chia seed Extract|
|E3550||Philippine flemingia root Extract|
|E3552||Euphorbia lathyris Extract|
|E3553||Climbing groundsel Extract|
|E3554||Rhizoma homalomenae Extract|
|E3555||Acmella oleracea Extract|
|E3557||Radix Peucedani Extract|
|E3558||Euryale ferox Extract|
|E3559||Radix rubiae Extract|
|E3560||Incised notopterygium rhizome Extract|
|E3561||Polygonum fagopyrum seed Extract|
|E3565||Celery seed Extract|
|E3566||Largeleaf Gentian Root Extract|
|E3567||Ash bark Extract|
|E3568||Natural indigo Extract|
|E3569||Caulis sinomenii Extract|
|E3571||Green Walnut Husk Extract|
|E3572||Green Tangerine peel Extract|
Ginseng is one of the most widely used herbal remedies, because it is believed to improve energy, physical and emotional health, and well-being.
|E3645||Pomegranate seed Extract|
|E3646||Selaginella Doederleinii Extract|
|E3648||Pyrrosia lingua Extract|
|E3649||Centaurea cyanus Extract|
|E3650||Diospyroskaki leaf Extract|
|E3651||Lycopodiastrum casuarinoides Extract|
|E3652||Rehmanniae radix praeparata Extract|
|E3654||Althaea rosea Extract(root)|
|E3655||Althaea rosea Extract(leaves)|
|E3656||Dichroa febrifuga Extract|
|E3657||Salvia japonica Extract|
|E3659||Silybum mariamum Extract|
|E3660||Polypodiodes niponica Extract|
|E3661||Prunus persica Extract|
|E3662||Buffalo Horn Extract|
|E3663||Retinerus luffae Fructus Extract|
|E3664||Luffa Cylindrica Stem Extract|
|E3665||60% Yucca schidigera Extract|
|E3666||Chloranthus helostegius Extract|
|E3667||Pine pollen Extract (flower)|
|E3668||Pine pollen Extract (flower bud )|
|E3669||Pine Nodular Branch Extract|
|E3670||Pine Bark Extract||
Pine Bark Extract is extracted from Pine bark. Pine bark extract is rich in bioflavonoids, predominantly proanthocyanidins, which are antioxidants. Pine Bark extract is used for preventing or treating various chronic conditions associated with oxidative stress. This is an update of a previously published review.
|E3671||Mesembryanthemum spectabile Extract|
|E3672||Pine needles Extract|
|E3673||Pine nuts Extract|
|E3674||Caesalpinia sappan Extract|
|E3676||Prunus cerasus Extract|
|E3677||Semen Ziziphi Spinosae Extract|
|E3678||Vitex agnus-castus Extract|
|E3679||Semen aesculi Extract|
|E3680||Aesculus chinensis Bunge fruits Extract|
|E3681||Cynomorium Songaricum Extract|
|E3683||Santalum album Extract|
|E3445||Hibiscus sabdariffa flower Extract|
|E3446||Chinese Starjasmine stem Extract|
|E3447||Air-Plant herb Extract|
|E3449||Green tea Extract|
|E3450||Phaseolus radiatus seed Extract|
|E3451||Mung bean peel Extract|
|E3452||Green Coffee bean Extract|
|E3453||Gnetum parvifolium Extract|
|E3454||Verbena herbs Extract|
|E3460||Bones of Cervus elaphus’ Extract|
|E3462||Coriaria Root Extract|
|E3463||Masson pine needle Extract|
|E3465||Radix Ophiopogonis Extract|
|E3466||Barley grass Extract|
|E3467||Malt fruit Extract|
|E3470||Mango leaf Extract|
|E3472||Spicate clerodendranthus Extract|
|E3473||Ternate buttercup root Extract|
|E3474||Fructus Chebulae Extract|
|E3475||Coleus forskohlii Extract|
|E3477||Rose hip Extract|
|E3483||Bee flower Extract|
|E3486||Jasmine flower Extract|
|E3488||Fucus vesiculosis Extract|
|E3489||Cuttlefish grass Extract|
|E3487||Ecliptae Herba Extract|
|E3490||Peony flower Extract|
|E3491||Paeonia suffruticosa root bark Extract|
|E3492||Vitex negundo seed Extract|
|E3494||Oyster Shell Extract|
Oyster peptide is derived from oyster meat by modern bio-enzymatic hydrolysis technology, and further separation, purification, deodorization and spray drying process.
|E3497||Momordicae Semen Extract|
|E3498||Pigeon pea leaves Extract|
|E3448||Chinese Astilbe rhizome Extract|
|E3499||Basella rubra Extract|
|E3501||Hibiscus mutabilis flower Extract|
|E3504||Oroxylum indicum seed Extract|
|E3506||Hibiscus bark Extract|
|E3508||Magnolia Obovata Extract|
|E3509||Akebia quinata Extract|
|E3512||Milk thistle Extract|
|E3513||Pumpkin seed Extract|
|E3514||Burdock root Extract|
|E3515||Great Burdock Achene Extract|
|E3516||Beautiful millettia root Extract|
|E3518||Daphniphyllum calycinum Extract|
|E3519||OX liver Extract|
|E3520||Beef tendon grass Extract|
|E3200||Bee Pollen Extract|
|E3204||Citri Sarcodactylis Fructus Extract|
|E3206||Spirodelae Herba Extract|
|E3207||Blighted Wheat Extract|
|E3210||Rubi Fructus Extract|
|E3212||Prunus Humilis Bunge Extract|
|E3214||Nardostachyos Rhizoma Extract|
|E3215||Kansui Radix Extract|
|E3217||Penthorum Chinense Pursh Extract|
|E3218||Zingiberis Rhizoma Extract|
|E3219||Flos Ascheri Extract|
|E3223||Alpiniae Officinarum Rhizoma Extract|
|E3226||Devil's Claw Extract|
|E3358||Rhizoma fagopyri dibotryis Extract|
|E3360||Lonicera japonica Extract||Lonicera japonica Extract (Japanese honeysuckle Extract), isolated from the leaves and flowers of Lonicera japonica (Japanese honeysuckle), possesses antipyretic, antibiotic, antioxidant, and anti-inflammatory activities.|
|E3361||Calendula officinalis flower Extract|
|E3362||Enoki mushroom Extract|
|E3364||Physalis alkekengi Extract|
|E3366||Fineleaf schizonepeta herb Extract|
|E3368||Chinese Chive seed Extract|
|E3371||Chrysanthemi Extract||Chrysanthemi Extract is extracted from Flos Chrysanthemi, which is often used to treat cold and flu, headache, blurred vision, red eyes, dizziness, and skin sores.|
|E3374||Exocarpium Citri Rubrum Extract|
|E3376||Saw palmetto Extract|
|E3380||Coffee fruit Extract|
|E3389||Sophora alopecuroides seed Extract|
|E3400||Chili pepper Extract|
|E3404||Raphanus sativus seed Extract|
|E3425||Dragon's blood Extract|
|E3426||Piper betle L. Extract|
|E3434||Deer antler velvet Extract|
|E3435||Pyrola herb Extract|
|E3436||Liquidambar formosana Extract|
|E3437||Apocynum venetum Extract|
|E3438||Momordica grosvenori Extract|
|E3440||Tamarindus indica seed Extract|
|E3441||Radish root Extract|
|E3442||Radish leaves Extract|
|E3812||Rhamnus Cathartica Extract|
|E3813||Chrysanthemum Indicum Extract|
|E3814||Phyllanthus Urinaria Extract|
|E3815||Caulis Polygoni Multiflori Extract|
|E3816||Emilia Sonchifolia Extract|
|E3817||Eucalyptus Globulus Fruit Extract|
|E3818||Solidago Decurrens Extract|
|E3820||Leonurus Japonicus Extract|
|E3821||Alpinia Oxyphyllae Extract|
|E3824||Scepteridium Ternatum Extract|
|E3825||Herba Artemisiae Capillaris Extract|
|E3827||Ginkgo Biloba Extract||Ginkgo biloba Extract is extracted from the leaves of the Ginkgo biloba L.. Ginkgo biloba Extract is used in an extensive range of disorders and diseases, including depressed mood, multi-infarct dementia, cerebral insufficiency (characterized by symptoms such as memory impairment, poor concentration, anxiety, and confusion), myocardial ischemia, stroke, thrombosis, and peripheral occlusive arterial disease (POAD).|
|E3829||Epimedium Brevicornu Extract|
|E3830||Prunus Serrulata Extract|
|E3831||Cherry Powder Extract (Pink) Extract|
|E3833||Cherry Extract (Brown) Extract|
|E3834||Jasminum Nudiflorum Extract|
|E3835||Cordyceps Militaris Extract|
|E3836||Cole Flowers Extract|
|E3838||Phyllanthus Emblica Extract|
|E3839||Houttuynia Cordata Extract|
|E3840||Ulmus Pumila Bark Extract|
|E3843||Corn Stigma Extract|
|E3844||Polygonatum Odoratum Extract|
|E3845||Radix Curcumae Root Extract|
|E3846||Semen Pruni Extract|
|E3848||Hypericum Sampsonii Extract|
|E3849||Scrophularia Ningpoensis Extract|
|E3850||Rhizoma Corydalis Extract|
|E3851||Radix Polygalae Extract|
|E3852||Oenothera Biennis Extract|
|E3853||Blueberry Fruit Extract|
|E3854||Coriolus Versicolor Extract|
|E3857||Gieditsia Sinensis Lam Fruit Extract|
|E3860||Euphorbia Helioscopia Extract|
|E3861||Rhizoma Alismatis Extract|
|E3862||Japanese Xylosma Twig Extract|
|E3863||Swertia Bimaculata Extract|
|E3865||Catharanthus Roseus Extract|
|E3867||Fritillariae Thunbergii Bulbus Extract|
|E3870||Gardenia Fruit Extract||Gardenia fruit Extract is extracted from the fruits of Gardenia jasminoides Ellis., a flowering plant belonging to Rubiaceae family. Gardenia fruit is used not only as a food coloring but also as a medicine to treat hepatic disorders, headache, jaundice, inflammation, and hypertension.|
|E3871||Valeriana Root Extract|
|E3872||Hovenia Dulcis Fruit Extract|
|E3873||Hovenia Dulcis Seed Extract|
|E3874||Hovenia Dulcis Extract|
|E3875||Unripe Bitter Orange Extract|
|E3877||Processed Cyperus Extract|
|E3879||Glabrous Sarcandra Herb Extract|
|E3880||Rhizoma Paridis Extract|
|E3881||Swine'S Gallbladder Extract|
|E3882||Swine'S Liver Extract||Pig's liver Extract is extract from the liver of swine, a valuable edible slaughter by-products suitable for human consumption.|
|E3883||Umbellate Pore Fungus Extract|
|E3884||Galium Aparine Extract|
|E3885||Swine‘S Pancreas Extract|
|E3886||Bamboo Sap Extract|
|E3887||Bamboo Shaving Extract|
|E3888||Cortex Illicii Extract|
|E3890||Lithospermum Erythrorhizon Extract|
|E3891||Red Cabbages Extract|
|E3892||Viola Philphica Munda Extract|
|E3893||Medicago sativa Extract|
|E3894||Ardisia Japonica Extract|
|E3895||Perilla Frutescens Extract|
|E3896||Perilla Leaf Extract|
|E3897||Purple Perilla Seed Extract|
|E3898||Radix Asteris Extract|
|E3899||Echinacea Extract (flower)||Purple coneflower Extract is extracted from purple coneflower, the flower of Echinacea purpurea, Echinacea angustifolia or Echinacea pallida. Purple coneflower is used as a treatment for respiratory tract infections and inflammatory conditions, including common cold, coughs, bronchitis, and inflammation of mouth and pharynx.|
|E3901||Ribes Henryi Root Extract|
|E3802||Inula Cappa Extract|
|E3803||Goat Liver Powder Extract|
|E3804||Aspen Flower Extract|
|E3805||Psyllium Husk Extract|
|E3806||Allium Cepa Extract|
|E3810||Bauhinia Variegata Extract|
|E3700||Descurainiae Semen Lepidii Semen Extract|
|E3701||Phryma Leptostachya L. var. asiatica Hara Extract|
|E3702||Eupolyphage sinensis Walker Extract|
|E3703||Talinum paniculatum Extract|
|E3704||Rumex madaio Makino Extract|
|E3705||Smilax glabra Extract|
|E3706||Cortex pseudolaricis Extract|
|E3707||Chenopodium ambrosioides Extract|
|E3708||Cephaelis ipecacuanha Extract|
|E3709||Lagotis glauca Extract|
|E3710||Chinese Dodder Seed Extract|
|E3712||Pisum sativum Extract|
|E3713||Vaccariae semen Extract|
|E3714||Clematis chinensis Extract|
|E3715||Crinum Asiaticum Extract|
|E3716||Equisetum arvense Extract|
|E3717||Lactuca sativa Extract|
|E3718||Marsdeniae Tenocissimae Extract|
|E3719||Seed of Chinese Tallowtree Extract|
|E3720||Oolong tea Extract|
|E3721||Fructus mume Extract|
|E3722||Zaocys dhumnades Extract|
|E3723||Lindera aggregata leaves Extract|
|E3724||Ficus carica Extract|
|E3737||Passiflora caerulea Linnaeus Extract|
|E3738||Lycopersicon esculentum Miller Extract|
|E3739||Panax quinquefolium Extract|
|E3740||Isodon serra Extract|
|E3741||Herba Siegesbeckiae Extract|
|E3742||SHILAJIT Asphaltum Extract|
|E3744||Prunella Vulgaris Extract|
|E3747||Agrimonia pilosa Extract|
|E3749||Curculigo orchioides Extract|
|E3750||Opuntia dillenii Extract|
|E3754||Coriander Roots Extract|
|E3755||Cyperus Rotundus Extract|
|E3756||Vetiveria Zizanioides Extract|
|E3757||Shiitake Mushroom Extract|
|E3760||Cymbopogon Citratus Extract|
|E3761||Elsholtzia Ciliata Extract|
|E3763||Sweet Potatoes Extract|
|E3765||Citrus Medica Extract|
|E3767||Justicia Gendarussa Extract|
|E3768||Foeniculum Vulgare Extract|
|E3769||Cirsium Setosum Extract|
|E3770||Wheat Germ Extract|
|E3771||Millet Extracts Extract|
|E3774||Chlorella Pyrenoidosa Extract|
|E3775||Valeriana Officinalis Extract|
|E3776||Allium Macrostemnon Extract|
|E3780||Pleurotus eryngii Extract|
|E3781||Bombyx Moril Extract|
|E3782||Arctostaphylos Uva Ursi Leaf Extract|
|E3783||Spiraea Salicifolia Extract|
|E3784||Cynanchum Paniculatum Extract|
|E3785||Radix Dipsaci Extract|
|E3786||Radix Scrophulariae Extract|
|E3787||Flos Inulae Extract|
|E3788||Smallanthus Sonchifolius Extract|
|E3789||Saussurea Involucrata Extract|
|E3790||Sambucus Adnata Extract|
|E3791||Surgentodoxa Cuneata Extract|
|E3792||Lavandula Angustifolia Extract|
|E3793||Urtica Fissa Extract|
|E3794||Brucea Javanica Extract|
|E3795||Commelina Communis Extract|
|E3797||Butea Superba Extract|
|E3798||Avena Sativa L. Extract|
|E3799||Arrhenatherum Elatius Extract||
Arrhenatherum elatius Extract is extracted from <I>Arrhenatherum elatius</i> (L.) Pressl.. Arrhenatherum elatius has ability to remove heavy metals from soil.
|E3800||Nidus Collocaliae Extract|
|E3576||Semen celosiae Extract|
|E3579||Undaria pinnatifida Extract|
|E3582||Ginseng leaf Extract|
|E3583||Honeysuckle flower Extract|
|E3584||Lonicera japonica vine Extract|
|E3585||Desertliving cistanche herb Extract|
|E3586||Myristica fragrans Extract|
|E3589||Evodia Lepta Bark Extract|
|E3592||Panax notoginseng Root Extract|
|E3590||Radix berberidis Extract|
|E3593||Panax notoginseng Rhizoma Extract|
|E3594||Radix tetrastigme Extract|
|E3595||White mulberry root-bark Extract|
|E3596||Phellinus linteus Extract|
|E3597||Herba taxilli Extract|
|E3598||Morus alba bark Extract|
|E3599||Mantis egg-case Extract|
|E3601||Mulberry Extract (leaves)||Mulberry Extract (leaves) is extracted from Mulberry (Morus alba L.) leaves , which are traditional Chinese herbs. Mulberry leaves exert several biological functions, such as antioxidant, anti-inflammation, antidiabetic, and antitumor.|
|E3658||Double coptis chinensis Extract|
|E3689||Radix Asparagi Extract||Radix Asparagi Extract is extracted from the dry root of Asparagus cochinchinensis (Lour.) Merr.(Liliaceae). Asparagi radix is efficacious against inflammation diseases due to its high antioxidant activity. The extract from Asparagi radix can inhibit browning reaction of mushroom, similar to ascorbic acid.|
|E3690||Semiaquilegiae Radix Extract|
|E3691||Gastrodia Rhizome Extract|
|E3692||lucid asparagus Extract|
|E3695||Hypericum japonicum Extract|
|E3696||Panax notoginseng Extract|
|E3578||Fringed pink Extract|
|E3175||Eucommia Ulmoides Male Flower Extract|
|E3181||Anona Squamosa Leaf Extract|
|E3183||Carica Papaya Leaf Extract|
|E3185||Psidium Guajava Extract|
|E3187||Descolor Cinquefoil Herb Extract|
|E3188||Cissus Quadrangularis Extract|
|E3190||Stephaniae Tetrandrae Radix Extract|
|E3191||Euphorbia Hirta Extract|
|E3193||Saponaria Officinalis Extract|
|E3198||Kadsura longipedunculata Ratan Extract|
|E3228||Cynodon Dactylon Extract|
|E3229||Lycii Fructus Extract|
|E3230||Eriocauli Flos Extract|
|E3231||Setariae Fructus Germinatus Extract|
|E3233||Trichosanthis Fructus Extract|
|E3236||Champion Wood Fern Extract|
|E3239||Osmanthus Extract||Osmanthus Extract is extracted from Osmanthus fragrans, which exhibits neuroprotective, free radical scavenging, and antioxidant effects and also acts as a good source of natural antiaging compounds.|
|E3243||Pinus Pinaster Bark Extract|
|E3244||Laminaria Japonica Extract|
|E3246||Lygodii Spora Extract|
|E3247||Hainan Nightshade Fruit Extract|
|E3300||Pericarpium Zanthoxyli peel Extract|
|E3301||Peanut hull Extract|
|E3302||Peanut seed coat Extract|
|E3303||Achyranthes bidentata Blume root Extract||Achyranthes bidentata Blume root Extract, isolated from the dried roots of Achyranthes bidentata Blume, has a beneficial effect on inhibition of adipogenesis and controlling body weight in rats fed with a high-fat diet.|
|E3304||Sophora japonica fruit Extract||Sophora japonica fruit Extract (Fructus Sophorae Extract, Rexflavone), isolated from the fruits of Sophora japonica, contains high contents of isoflavones, and is a health functional food ingredient that significantly improves the menopausal index.|
|E3305||Sophora flower Extract||Sophora flower Extract is extracted from dried flowers of Sophora japonica (Huaihua), which is used in China, Japan and Korea for treating haematemesis and bleeding haemorrhoids.|
|E3306||Phellodendron amurense bark Extract||Phellodendron amurense bark Extract (Nexrutine), isolated from the barks of Phellodendron amurense, has shown a favorable effect on prostate cancer in vivo and in vitro.|
|E3308||Daylily flower Extract||
Daylily flower Extract, isolated from the flower and bud parts of Hemerocallis citrina, has the effects of neuroprotection.
|E3309||Polygala fallax Hemsl. rhizome Extract|
|E3310||Brassica juncea seed Extract||
Brassica juncea seed Extract, isolated from the seeds of brown (<i>Brassica juncea</i>) mustard, contains abundant phenolic compound.
|E3311||Rhizoma polygonati root Extract||
Rhizoma polygonati root Extract, isolated from the roots of <i>Rhizoma polygonati</i>, has been used for a long history with many chemical components in inducing anti-cancer, anti-aging, anti-diabetes, anti-fatigue, and more prevention of diseases or acts as nutrition sources in food
|E3312||Rhizoma Coptidis Root Extract||
Rhizoma coptidis root Extract, isolated from the dried roots of medicinal plants from <i>Rhizoma coptidis</i> (Ranunculaceae), has been used by Chinese medicinal physicians for more than 2000 years.
|E3315||Astragalus rhizome Extract||
Astragalus rhizome Extract, isolated from the rhizome of Radix Astragali, contains main constituents of polysaccharides, flavonoids, and saponins, amino acids and trace elements, with anti-inflammatory, immunomodulation, anti-oxidant, and anticancer effects.
|E3316||Scutellariae rhizome Extract||
Scutellariae rhizome Extract is isolated from the rhizome of <i>Scutellaria baicalensis</i>, which contains baicalin as a main constituent, has long been used in China, Japan, and Korea as a traditional medicine and functional food for inflammation, fever, hepatitis, allergic disease, hypertension, etc.
|E3317||Okra fruit Extract||
Okra fruit extract (Abelmoschus esculentus fruit extract), isolated from the fruits of <i>Abelmoschus esculentus</i>, is used as an alternative treatment because of its various medicinal properties, such as antidiabetic, antioxidant, antiplasmodial, antibacterial, anticancer, analgesic, antidiarrheal, and anti-inflammatory properties.
|E3318||Cistus Incanus Extract||
Cistus Incanus Extract, isolated from Mediterranean shrub species Cistus incanus L., is rich in polyphenolic compounds, possesses significant antioxidant activity, and may be effective active ingredients for the cosmetic industry.
|E3323||Plumeria rubra Extract|
|E3324||Herba abri Extract|
|E3325||Croton crassifolius Geisel. Extract|
|E3327||Chinese fevervine herb Extract|
|E3329||Centella asiatica Extract|
|E3331||Impatiens balsamina L. Extract|
|E3333||Viburnum dilatatum Extract|
|E3337||Larva of a Silkworm with Batrytis Extract|
|E3338||Lignum Dalbergiae odoriferae Extract|
|E3342||Carob bean Extract|
|E3343||Gynostemma pentaphyllum Extract||
Gynostemma pentaphyllum Extract, isolated from the herb of <i>Gynostemma pentaphyllum</i>, enhances exercise performance by promoting myotube differentiation and mitochondrial metabolism through the upregulation of PGC-1α in C2C12 skeletal muscle.
|E3348||Capsella bursa-pastoris Extract|
|E3353||Acacia farnesiana Extract|
|E3574||Cyclocarya paliurus Extract|
|E3307||Soybean Extract||Soybean Extract, isolated from the seeds of Soybean, modulates retinoic acid-related genes and shows photo-protective effects, suggesting that soybean Extract could be an anti-ageing ingredient that can be safely used under the sunlight.|
Azadirachtin B, a limonoid isolated from seed kernels of <i>Azadirachta indica</i>, has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties.
|E3122||Arecae Pericarpium Extract|
|E3124||Cirsii Japonici Herba Extract|
|E3148||Euphorbiae Humifusae Herba Extract|
|E3150||Dinian Herb Extract|
|E3151||Sanguisorbae Radix Extract|
|E3156||Clitoria Ternatea Flower Extract|
|E3157||Erycibes Caulis Extract|
|E3158||Caryophylli Flos Flower Extract|
|E3163||Wax Gourd Seed Extract||Wax Gourd Seed Extract is extracted from the fruit of Benincasa hispida, which acts as an anti-inflammatory, cardiovascular, hepatoprotective, and exibits cytotoxicity towards breast cancer cells.|
|E3164||Malvae Fructus Extract|
|E3168||Bean Sprout Extract|
|E3039||Angelica Root Extract|
|E3042||Lily Bulbs Extract|
|E3044||Passion Fruit Extract|
|E3049||Lobeliae Chinensis Extract|
|E3053||Mentha Arvensis Leaf Extract|
|E3054||Primula Malacoides Extract|
|E3071||Malaytea Scurfpea Extract|
|E3074||Xanthium Sibiricum Extract|
|E3075||Atractylodis Rhizoma Extract|
|E3077||Tsaoko Fructus Extract|
|E3080||Platycladi Cacumen Extract|
|E3084||Hedera Helix Extract|
|E3099||Fritillaria Cirrhosa Seed Extract|
|E3100||Sichuan Pepper Extract|
|E3101||Toosendan Fructus Extract|
|E3105||Cochinchina Cudrania Root Extract|
|E3111||Tribulus Terrestris Extract|
|E3113||Rosa Roxburghii Root Extract|
|E3249||Mimosa Pudica Root Extract|
|E3250||Mimosa Pudica Extract|
|E3251||Tropaeolum Majus Extract|
|E3254||Terminalia Chebula Extract|
|E3257||Polygoni Multiflori Root Extract|
|E3261||Juglandis Semen Extract|
|E3262||Walnut Leave Extract|
|E3264||Black Bone Rattan extract|
|E3265||Black Pepper Extract|
|E3266||Black Carrot Extract|
|E3267||Black Coffee Extract|
|E3268||Black Quinoa Extract|
|E3269||Black Ant Extract|
|E3272||Black Garlic Extract|
|E3274||Nigella Sativa Extract (Herb)|
|E3275||Nigella Sativa Extract (Seed)|
|E3276||Red Ginseng Extract|
|E3277||Black Tea Extract|
|E3278||Black Tea Root Extract|
|E3280||Trifolium Pratense Extract|
|E3282||Taxus Cuspidata Extract|
|E3287||Red Yeast Rice extract|
|E3290||Citrus Grandis Fruit Extract|
|E3291||Hydrolyzed Rhodophycea Extract|
|E3292||Hericium Erinaceus Extract|
|E3293||Magnolia Bark Extract|
|E3296||Juglans Regia Extract|
|E3298||Viscum Coloratum Extract|
|E3019||Semen Ginkgo Extract|
|E3029||White Paeony Root Extract|
|E3032||Atractyloides Macrocephala Root Extract|
|E3001||Donkey-hide gelatin Extract||
Donkey-hide gelatin Extract is extracted from Donkey-hide gelatin (Asini Corii Colla, ACC), a gelatinous Chinese medicine known as Ejiao in Chinese. Donkey-hide gelatin is applied as an important food therapy product to optimize immune response, improve metabolic balance and treat gynecological diseases.
|E3004||Eucalyptus Leaf Extract|
|E3005||Boesenbergia Pandurata Extract|
|E3009||Morinda Root Extract|
|E3013||Chinese Cabbage Extract|
|E3015||Amomum Kravanh Extract|
|E3016||Cissus modecoides var Extract|
|E3017||Poria Cocos Extract|
|E3000||Ligusticum Sinense Extract||Ligusticum Sinense Extract is extracted from Ligusticum sinense, a Chinese medicinal plant.|
|E3603||Ramulus Mori Extract||Ramulus Mori Extract is extracted from Ramulus mori (Mulberry twigs), the dry branch of Morus alba L.. Ramulus Mori is a traditional medicine widely used for diabetes treatment. The major active components of Ramulus Mori are mulberroside A, oxyresveratrol, resveratrol, 4-hydroxycinnamic acid, 7-hydroxycoumarin, and morin, and the components have been demonstrated to possess anti-cancer, anti-hypertensive, anti-diabetic, and anti-inflammatory properties.|
|E3604||Adenophora Stricta Extract||Adenophora stricta Extract is extracted from Adenophora stricta Miq.. Adenophora stricta is commonly used to reduce phlegm, clear lung and tonify stomach.|
|E3605||Sea buckthorn Extract (fruits)||Sea buckthorn Extract (fruits) is extracted from the fruits of sea buckthorn (Hippophae rhamnoides L.). Sea buckthorn has significant cardioprotective activity and exerts many positive healing effects on the cardiovascular system, including inhibiting blood platelet activation (especially platelet aggregation), lowering cholesterol concentration and blood pressure, and providing antioxidant activity. Sea buckthorn also has antibacterial and antiviral properties.|
|E3606||Sea buckthorn Extract (leaves)||Sea buckthorn Extract (leaves) is extracted from the leaves of sea buckthorn (Hippophae rhamnoides L.). Sea buckthorn has significant cardioprotective activity and exerts many positive healing effects on the cardiovascular system, including inhibiting blood platelet activation (especially platelet aggregation), lowering cholesterol concentration and blood pressure, and providing antioxidant activity. Sea buckthorn also has antibacterial and antiviral properties.|
|E3607||Crateva nurvala Extract||Crateva nurvala Extract is extracted from the stem bark of Crataeva nurvala Buch.. Crateva nurvala, an important medicinal plant, has been studied mainly with the stem bark part for obstructive and nonobstructive uropathies. Crateva nurvala is also used for the treatment of prostate enlargement and bladder sensitivity.|
|E3608||Semen astragali complanati Extract||Semen astragali complanati Extract is extracted from Semen Astragali Complanati, the dried ripe seed of Flatstem Milkvetch (Astragalus complanatus Bunge) (Leguminosae). The major contents of Semen astragali complanati include fatty acids, amino acids, polysaccharides, flavonoids, triterpene glycosides and trace elements. Semen astragali complanati exhibits a number of therapeutic effects on chronic diseases such as cardiovascular diseases, diabetes mellitus and cancers.|
|E3609||Elaeagnus angustifolia Extract||Elaeagnus angustifolia Extract is extracted from the fruits of Elaeagnus angustifolia L.. Elaeagnus angustifolia fruit extract has acute and chronic anti-inflammatory activities.|
|E3610||Amomum villosum Extract||Amomum villosum Extract is extracted from Amomum villosum Lour., a herbaceous plant in the ginger family. Amomum villosum has been proven to be effective in treating gastrointestinal diseases. Treatment with Amomum villosum water extract significantly attenuates intestinal inflammation in inflammatory bowel disease (IBD) rats.|
|E3611||Camellia japonica Extract||Camellia japonica Extract is extracted from the flowers of Camellia japonica L.. Camellia japonica possesses antimicrobial, antioxidant and antitumoral activity and as being a huge source of polyphenols such as the catechins.|
|E3612||Cremastra appendiculata Extract||Cremastra appendiculata Extract is extracted from Cremastra appendiculata (Pseudobulbus Cremastrae seu Pleiones), the dried pseudostem of plants of the Orchidaceae family. Cremastra appendiculata has antibacterial, antihypertensive, gout, antitumor, and acetylcholine receptor M3-blocking effects. The extract of cremastra appendiculata can be used to treat Lewis lung cancer, liver cancer, and breast cancer.|
|E3613||Sophora tonkinensis Extract||Sophora tonkinensis Extract is extracted from the dried root ofSophora tonkinensis Gapnep.. Sophora tonkinensis is used in the treatment of pharyngeal and laryngeal diseases. Sophora tonkinensis has hepatoprotective, immunomodulatory, and anticancer effects and produces obvious toxicity to the liver and nervous and cardiovascular systems.|
|E3614||Arnica montana Extract||Arnica montana Extract is extracted from the flowers of Arnica montana L. (Asteraceae). Arnica montana possesses anti-inflammatory, immune-modulatory, anti-sclerotic, analgesic, antifungal, antioxidant, antibacterial, and anticancer bioactivities.|
|E3616||Kaempferia galanga Extract||Kaempferia galanga Extract is extracted from the rhizome of Kaempferia galanga L. (Zingiberaceae). Kaempferia galanga is used to get relief from indigestion, swelling, pain, high blood pressure, and dyslipidemia.|
|E3617||Galega officinalis Extract||Galega officinalis Extract is extracted from the seeds of Galega officinalis L.. Galega officinalis extract has hypoglycemic and antioxidant properties.|
|E3618||Yam Extract||Yam Extract is extracted from yam (Chinese yam), the rhizome of various species of genus Dioscorea opposita Thunb. (Dioscoreaceae). Yam contains mainly proteins, sugars, vitamins, fats, choline, amylase, iodine, iron, calcium, phosphorus, and other indispensable trace elements in the human body. The main pharmacological effects of yam are antioxidative, anti-aging, anti-tumor, and hypoglycemic. Yam also can enhance immunity.|
|E3619||Lonicerae Flos Extract||Lonicerae Flos Extract is extracted from Lonicerae flos, the flower bud of Lonicera macranthoides Hand.-Mazz., Lonicera hypoglauca Miq., Lonicera confusa DC., or Lonicera fulvotomentosa Hsu et S. C. Cheng. Lonicerae flos is a traditional Chinese medicine used in the treatment of inflammatory and infectious diseases. Lonicerae flos extract increases survival rates of cecal ligation and puncture (CLP)-induced septic rats.|
|E3620||Corni Fructus Extract||orni Fructus Extract is extracted from the fruits of Fructus Corni (Cornus officinalis Sieb. et Zucc.). Fructus Corni is a traditional Chinese herbal medicine that possesses pharmacological actions against inflammation, diabetic nephropathy, tumors, oxidation and aging.|
|E3621||Crataegi fructus Extract||Crataegi fructus Extract is extracted from the fruits of Crataegi fructus (hawthorn). Crataegi fructus is dry ripe fruit of Crataegus pinnatifida Bge.var. major N. E. Br. or Crataegus pinnatifida Bge.. The extracts and compounds from fructus crataegi show a variety of pharmacological activities, such as a protective effect on patients with heart failure, as well as an increased force of myocardial contraction, improved coronary circulation, antioxidant effects and antimicrobial activities.|
|E3623||Pelargonium hortorum Extract||Pelargonium hortorum Extract is extracted from Pelargonium hortorum L.H. Bailey. Pelargonium cultivars have been reported as metal hyperaccumulators, with the ability to acidify soil pH. Pelargonium hortroum has the ability to accumulate Pb in shoots.|
|E3624||Phytolaccae Radix Extract||Phytolaccae Radix Extract is extracted from Phytolaccae Radix (the dried root of Phytolacca acinosa Roxb. or Phytolacca americana L.). Radix Phytolaccae is widely used for the treatment of inflammation-related diseases.|
|E3625||Cnidii Fructus Extract||Cnidii Fructus Extract is extracted from Cnidii Fructus, the dry ripe fruit of Cnidium monnieri (L.)Cuss.. Chinese herbal medicine Cnidii Fructus has an outstanding effect on chronic lumbar pain and impotence, also has been used against osteoporosis with high frequency.|
|E3626||Snake Gallbladder Extract||Snake Gallbladder Extract is extracted from Snake gallbladder. Snake gallbladder has multiple pharmacological effects, such as relieving coughs and asthma, as well as improving human immunity and visual acuity. Snake gallbladder has been believed in various Asian countries to improve visual acuity and alleviate rheumatism|
|E3627||Belamcandae Rhizoma Extract||Belamcandae Rhizoma Extract is extracted from dry roots of Belamcanda chinensis (L.) DC.. Belamcanda chinensis is mainly used to treat sore throat, bronchitis, and chronic tracheitis. Isoflavonoids, including irigenin, isolated from the rhizome of Belamcanda chinensis have been suggested to possess not only antioxidative and anti-inflammatory, but also antitumor activities.|
|E3629||Lycopodii Herba Extract||Lycopodii Herba Extract is extracted from Lycopodii Herba, the dried whole plant of Lycopodium japonicum Thunb. (Lycopodiaceae). Lycopodii Herba possesses anti-inflammation activity, antioxidative activity, and antitumor activity; and has been traditionally used for the prevention and treatment of various diseases such as rheumatoid arthritis, contusion, quadriplegia, dysmenorrhea.|
|E3630||Massa Medicata Fermentata Extract|
|E3631||Cimicifugae Rhizoma Extract|
|E3632||Rehmanniae Radix Extract|
|E3636||Ocimum sanctum Extract|
|E3637||Acorus tatarinowii Extract|
|E3638||Lysinotus pauciflorus Extract|
|E3639||Gypsum fibrosum Extract|
|E3640||Dendrobii caulis Extract|
|E3641||Salvia Chinensis Benth Extract|
|E3642||Haliotidis concha Extract|
|E3643||Pomegranate Peel Extract|
|E0840||Yakuchinone A||Yakuchinone A, a natural product isolated from Alpinia oxyphylla Miquel (Zingiberaceae), has strong inhibitory effects on the synthesis of prostaglandins (PGs) and leukotrienes (LTs).|
|E2012||Ginkgolide K||Ginkgolide K, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway, and possesses neuroprotective activity.|
|S0970||Curzerene||Curzerene, a sesquiterpene isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity, inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression and induces cell apoptosis.|
Isoscabertopin is a sesquiterpene lactone isolated from <i>Elephantopus scaber L</i> and shows anti-tumor activities.
OJV-VI is isolated from <i>ophiopogonis</i>.
Hypocrellin B is a natural product isolated from the fungi <i>Hypocrella bambusae</i> and <i>Shiraia bambusicola</i> with the induction of apoptosis.
|S6370||Dendrophenol||Dendrophenol (Moscatilin) is from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity. Dendrophenol (Moscatilin) almost completely suppresses (97%) the AFB1-induced SOS response with an IC50 of 0.08 μM.|
|S0938||Sakuranetin||Sakuranetin belongs to the group of methoxylated flavanones, with a widely bioactivity of antiproliferative against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320), antiviral activity towards human rhinovirus 3 and influenza B virus, antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties.|
|E0505||Olive oil||Olive oil comes from the fruits of Olea europae trees with a beneficial effect on human health, including the antioxidant activity and anti-inflammatory activity when olive oil is in regular diet.|
|E0506||Soybean oil||Soybean oil is a vegetable oil extracted from the seeds of the soybean (Glycine max).|
|E0656||7-Methylcoumarin||7-Methylcoumarin can inhibit the growth of S. aureus and the growth of Gram-positive bacteria within a concentration of 0.8–3.6 μg/ml, and also has a strong hepatoprotective activity.|
|E0748||Opoponax oil||Opoponax oil is isolated and extracted from Commiphora erythraea (opoponax), with a promising insecticidal property.|
|E1124||Narciclasine||Narciclasine (Lycoricidinol), an isocarbostyril alkaloid narciclasine, targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells. Narciclasine suppresses phosphorylation, activation, dimerization, and nuclear translocation of STAT3 by directly binding with the STAT3 SH2 domain and leads STAT3 degradation. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.|
|E0650||γ-Terpinene||γ-Terpinene (γ-TPN), a monoterpene, is an orally active antioxidant compound which can scavenge radicals directly.|
|E0651||Garlic oil||Garlic oil blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis by inducing phase II drug-metabolizing enzymes.|
|S4448||Imidacloprid-urea||Imidacloprid-urea with a role as a marine xenobiotic metabolite, is the primary imidacloprid soil metabolite, whereas imidacloprid-olefin is the main plant-relevant metabolite and is more toxic to insects than imidacloprid.|
|E0653||Trans-ferulic acid||Trans-ferulic acid is a potent activator of AMPKunder high glucose condition.|
Cornuside is a bisiridoid glucoside compound isolated from the fruit of Cornus officinalis SIEB. et ZUCC. Cornuside suppresses lipopolysaccharide-induced inflammatory mediators by inhibiting NF-κB activation in RAW 264.7 macrophages. Cornuside attenuates apoptosis in rat cortical neurons.
Bruceine D, isolated from Brucea javanica (L.) Merr. (Simaroubaceae), shows antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway.
Isorhapontigenin (ISOR), isolated from Belamcanda chinensis, is a derivative of stilbene. Isorhapontigenin possessed potent antioxidative activity. Isorhapontigenin suppresses interleukin-1β-induced inflammation and cartilage matrix damage in rat chondrocytes.
Hinokiflavone, isolated from Selaginella P. Beauv, Juniperus phoenicea and Rhus succedanea, possesses excellent pharmacological activities, including anti-inflammatory, antioxidant and antitumor activity. Hinokiflavone induces apoptosis and inhibits migration of breast cancer cells via EMT signalling pathway.
Invert Sugar is a popular sweetener.
Dihydroberberine, a hydrogenated derivative of Berberine (BBR), exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways.
|S0941||3,29-O-dibenzoyloxykarounidiol||3,29-O-dibenzoyloxykarounidiol is a triterpenoid isolated from Trichosanthes kirilowii Maxim.|
|S5813||Isoginkgetin||Isoginkgetin is a naturally derived biflavonoid with anti-tumor activity. Isoginkgetin directly inhibits the chymotrypsin-like, trypsin-like, and caspase-like activities of the 20S proteasome. Isoginkgetin also is a general inhibitor of Pre-mRNA splicing.|
|S0958||Zingibroside R1||Zingibroside R1, isolated from rhizomes of Panax zingiberensis Wu et Feng (Araliaceae), has some anti-HIV-1 activity. Zingibroside R1 shows the inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells with IC50 of 91.3 µM and the growth of MT-4 cells with CC50 of 46.2 µM.|
Ginkgetin is a biflavone from Ginkgo biloba leaves with anti-cancer, anti-inflammatory, anti-microbial, anti-adipogenic, and neuroprotective activities.
Chebulinic acid, a phenolic compound isolated from Terminalia chebula fruit, is a novel Influenza viral neuraminidase inhibitor. Chebulinic acid is a antiangiogenic agent through inhibiting the actions of VEGF. Chebulinic acid shows antitumour activity.
Herbacetin is a natural flavonoid compound found in flaxseed with strong antioxidant, antitumor and anti-inflammatory activity.
Cinobufotalin, extracted from the skin secretion of the giant toad, is a novel SREBP1 inhibitor that suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
Quercetin 3-O-β-D-glucuronide (Miquelianin, Q3GA) is one of the quercetin metabolites with antioxidant activity.
Glaucocalyxin A is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx with antitumor and anti-inflammatory activity. Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells.
Licochalcone B (Lico B), extracted from Glycyrrhiza uralensis Fisch, induces the cell cycle arrest and apoptosis in human hepatoma cell HepG2. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.
Chebulagic acid, isolated form Terminalia chebula Retz, is a reversible and non-competitive inhibitor of maltase with a Ki value of 6.6 μM. Chebulagic acid shows potent anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. Chebulagic acid also shows potent COX–LOX dual inhibition activity with IC50 values of 15 μM, 0.92 μM and 2.1 μM for COX-1, COX-2 and 5-LOX respectively.
14-Deoxy-11,12-didehydroandrographolide (deAND), a diterpenoid in Andrographis paniculata (Burm. f.) Nees with hypotensive, anti-inflammatory, anti-asthma, and anti-cancer activities.
|E0177||Hydrocortisone sodium succinate||
Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM. Hydrocortisone sodium succinate can bind to glucocorticoid receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators.
|E0201||Hypaconitine||Hypaconitine (Deoxymesaconitine) is an active diterpene alkaloid derived from Aconitum species. Hypaconitine inhibits TGF-β1-induced epithelial–mesenchymal transition.|
|E0202||Benzoylmesaconine||Benzoylmesaconine (Mesaconine 14-benzoate) is a main Aconitum alkaloid isolated from several Aconitum species with potent pharmacological activities, such as analgesia and anti-inflammation.|
|E0204||Poricoic acid A||Poricoic acid A is isolated from the surface layer of Poria cocos. Poricoic acid A activates AMPK to attenuate fibroblast activation and abnormal extracellular matrix remodelling in renal fibrosis. Poricoic acid A also is a modulator of tryptophan hydroxylase-1 (TPH-1).|
|E0205||Strictosamide||Strictosamide is the main representative constituent of Nauclea officinalis Pierre ex Pitard (Rubiaceae) with anti-inflammatory and analgesic activities.|
|S7758||Trabectedin||Trabectedin (Ecteinascidin 743, ET-743) is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata with antitumour activity. Trabectedin binds to the N2 of guanine in the minor groove, causing DNA damage and affecting transcription regulation in a promoter- and gene-specific manner.|
|S0651||N-Butanoyl-L-homoserine lactone||N-Butyryl-L-homoserine lactone (N-Butanoyl-L-homoserine lactone, N-Butyrylhomoserine lactone, C4-HSL) is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). N-Butyryl-L-homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and cellular metabolism.|
Hexaminolevulinate hydrochloride (5-Aminolevulinic acid hexyl ester hydrochloride) is a tumour photosensitizer.
Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.
|S0920||Ginkgolide J||Ginkgolide J is a minor constituent of terpene trilactone mixture of Ginkgo biloba leaves extract that inhibits GlyR-operated channels with IC50 of 2.0 μM. Ginkgolide J also inhibits cell death of rodent hippocampal neurons caused by Aβ1–42. Ginkgolide J exhibits anti‑inflammatory activity.|
Pristane (2,6,10,14-Tetramethylpentadecane, TMPD) is a natural saturated terpenoid alkane obtained primarily from shark liver oil that is widely used to induce tumorgenesis in mice and arthritis and lupus nephritis in rats.
Miglustat (Zavesca, N‐butyldeoxynojirimycin, OGT 918) is an orally administered ceramide glucosyltransferase inhibitor which prevents the lysosomal accumulation of glucocerebroside.
Alloxan Monohydrate is the most popular diabetogenic agents used for assessing the antidiabetic or hypoglycemic capacity of test compounds.
4-Hydroxynonenal (4-HNE, HNE, 4-hydroxy Nonenal, 4-hydroxy-2-nonenal) is one of the major end products of lipid peroxidation and has been widely accepted as an inducer of oxidative stress.
Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. Carrageenan shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity.
Papain (papaya proteinase I) is a sulfhydryl protease from the latex of the papaya fruit. Papain breaks down intercellular matrix of cartilage.
Thioacetamide (TAA) is a hepatotoxin frequently used for experimental purposes which produces centrilobular necrosis after a single dose administration.
|E0154||Taurocholic acid sodium salt||
Taurocholic acid sodium salt (Sodium Taurocholate, TANa) is a sodium salt of taurocholic acid and occurs in the bile of mammals. Taurocholic acid is used as a cholagogue and choleretic.
ITE (2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester) is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) that directly binds to AHR with a Ki of 3 nM.
|S6812||Z-Guggulsterone||Z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Z-Guggulsterone exhibits anti-inflammatory effects in microglia. Z-Guggulsterone induces apoptosis in gastric cancer cells through the intrinsic mitochondria-dependent pathway.|
|E0129||Oxysophocarpine||Oxysophocarpine (OSC) is an alkaloid extracted from Sophora alopecuroides. Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) by targeting the Nrf2/HO-1 axis. OSC protects cells against apoptosis and inflammatory responses and compromised miR-155 activity by attenuating MAPK and NF-κB pathways.|
Apigenin-7-O-glucuronide (Apigenin-7-glucuronide) is the major flavonoid found in milk thistle. Apigenin 7-o-glucuronide inhibits tumor necrosis factor alpha (TNF-α) and total nitrite release in lipopolysaccharide-activated macrophages.
Iberiotoxin (IbTX) is a toxin purified from the scorpion Buthus tamulus. Iberiotoxin is a potent blocker of the large conductance Ca(2+)-activated K+ channel with a Kd of ~1 nM.
|S0947||Cafestol||Cafestol is a natural diterpenes extracted from coffee beans. Cafestol induces apoptosis and regulates a variety of inflammatory mediators to reduce inflammation. Cafestol inhibits PI3K/Akt pathway. Cafestol also can reduce the production of ROS in the leukemia cell line HL60.|
|E0046||β-Cyclodextrin||β-Cyclodextrin (β-CD, Beta-Cyclodextrin) is a cyclic derivative of starch prepared from partially hydrolyzed starch (maltodextrin) by an enzymatic process. β-Cyclodextrin can be used as complexing agents to increase aqueous solubility of poorly soluble drugs and to increase their bioavailability and stability.|
Chelerythrine (Toddaline, Broussonpapyrine) is a potent, selective antagonist of PKC with an IC50 of 0.66 μM. Chelerythrine also inhibits the BclXL-Bak BH3 peptide binding with an IC50 of 1.5 μM. Chelerythrine shows antitumor, antidiabetic and anti-inflammatory activity.
Cucurbitacin-I (Elatericin B, JSI 124, NSC 521777), a natural cell-permeable triterpenoid isolated from Cucurbitaceae, is a novel selective inhibitor of JAK2/STAT3.
|S7580||Leptomycin B||Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM–10 nM.|
Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF.
|S0950||Hibifolin||Hibifolin (Gossypetin-8-O-β-D-glucuronide) is a flavonol glycoside and acts as a potential inhibitor of adenosine deaminase (ADA) with a Ki of 49.92 μM. Hibifolin prevents β-amyloid-induced neurotoxicity in cultured cortical neurons.|
|E0010||Hypocrellin A||Hypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signaling pathways. Hypocrellin A also is a selective and potent inhibitor of PKC.|
|E0027||5-Hydroxymethylcytosine||5-Hydroxymethylcytosine (5hmC) is a naturally existing component in mammalian genomic DNA and is regarded as the sixth DNA base. 5-Hydroxymethylcytosine is an intermediate metabolite in active DNA demethylation. 5-Hydroxymethylcytosine is epigenetic marks known to affect global gene expression in mammals.|
|E0025||2-Hydroxybenzylamine||2-Hydroxybenzylamine (2-(Aminomethyl)phenol, 2-HOBA, NSC 127870) is a naturally occurring compound found in buckwheat and is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles. 2-HOBA reduces inflammation and plaque apoptotic cells and promotes efferocytosis and features of stable plaques. 2-HOBA has potential for use as a nutrition supplement due to its ability to protect against the damaging effects of oxidative stress.|
|E0008||Atractylodin||Atractylodin (Atractydin) is one of the major constituents of the rhizome of Atractylodes lancea and inhibits N-acylethanolamine-hydrolyzing acid amidase (NAAA) activity with an IC50 of 2.81 µM. Atractylodin also inhibits interleukin-6 (IL-6) by blocking NPM-ALK activation and MAPKs.|
|E0009||Harmane||Harmane (Harman, Aribine, Aribin, Locuturine, Locuturin, Loturine, Passiflorin, 1-Methylnorharman, NSC 54439) is a common compound in several foods, plants and beverages. Harmane is a selective monoamine oxidase inhibitors with IC50s of 0.5 μM and 5 μM for human MAO A and MAO B, respectively. Harmane also inhibits the apurinic/apyrimidinic (AP) endonuclease activity of the UV endonuclease induced by phage T4.|
|E0022||Ophiopogonin D||Ophiopogonin D (OJV-VI, Deacetylophiopogonin C) is a steroidal glycoside isolated from Chinese herb Radix ophiopogonis and shows anti-tumor property. Ophiopogonin D could suppress TGF-β1-mediated metastatic behavior of MDA-MB-231 cells by regulating ITGB1/FAK/Src/AKT/β-catenin/MMP-9 signaling axis. Ophiopogonin D attenuates PM2.5-induced inflammation via suppressing the AMPK/NF-κB pathway in mouse pulmonary epithelial cells.|
|S9197||Maltohexaose||Maltohexaose (Amylohexaose) is a polysaccharide with 6 units of glucose and can be classified as a maltodextrin.|
|S0943||Arenobufagin||Arenobufagin is a natural bufadienolide from toad venom and induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway.|
|S6909||Levomefolic acid||Levomefolic acid (5-MTHF, LMSR, Metafolin, Nutrifolin) is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.|
|S6927||Dihydroresveratrol||Dihydroresveratrol is a natural product possessing significant biological activities. Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator.|
|S3166||Calcium 2-oxoglutarate||Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) is the Calcium salt form of 2-oxoglutarate. 2-oxoglutarate is naturally found in organisms and is a well-known intermediate in the production of ATP or GTP in the Krebs cycle. 2-oxoglutarate is a reversible inhibitor of tyrosinase with IC50 of 15 mM.|
|S5910||Alpha-Estradiol||Alpha-Estradiol (α-Estradiol, 17 alpha-Estradiol, Alfatradiol, Epiestradiol, Epiestrol, Alora, 17 α-E2), a natural, non-feminizing stereoisomer, a hormonally almost inactive isomer of physiological 17 beta-estradiol (17 β-E2), is a weak inhibitor of estrogen.|
|S5417||Spectinomycin dihydrochloride pentahydrate||Spectinomycin dihydrochloride pentahydrate (Trobicin) is a widely used antibiotic that inhibits bacterial protein synthesis by blocking translocation of messenger RNA and transfer RNAs on the ribosome.|
|S5972||Hydrocortisone hemisuccinate||Hydrocortisone hemisuccinate (A-hydrocort, Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid with anti-inflammatory properties, is an inhibitor of proinflammatory cytokine with IC50 of 6.7 μM and 21.4 μM for Interleukin-6 (IL-6) and IL-3, respectively.|
|S9827||Iodoacetamide||Iodoacetamide (IA, IAM, 2-Iodoacetamide) is an alkylating agent that is commonly used for alkylation of cysteine during sample preparation for proteomics.|
|S5958||Metformin||Metformin (1,1-Dimethylbiguanide), a widely used drug for treatment of type 2 diabetes, activates AMP-activated protein kinase (AMPK) in hepatocytes. Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.|
|S5937||DL-Carnitine||DL-Carnitine ((±)-Carnitin) is a racemic mixture of L-Carnitine and D-Carnitine that regulates fatty acid transport in the mitochondrion. DL-carnitine is found to be ineffective or toxic, for example, to muscle cells and to the myocardium. DL-Carnitine causes symptoms of myasthenia and cardiac arrhythmias.|
|S5955||Thiamine nitrate||Thiamine (Vitamin B1) nitrate is an essential vitamin that plays an important role in cellular production of energy from ingested food and enhances normal neuronal actives.|
|S5888||Beclamide||Beclamide (N-Benzyl-3-chloropropionamide, beta-chlorpropionamide) exhibits sedative and anticonvulsant properties.|
|S5199||Oxytetracycline hydrochloride||Oxytetracycline (OTC, Oxycycin, Stevacin, Terramycin) hydrochloride is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.|
|S4486||Thiamine monochloride||Thiamine (Vitamin B1) monochloride is an essential vitamin that plays an important role in cellular production of energy from ingested food and enhances normal neuronal actives.|
|S4495||Quinine||Quinine, an alkaloid derived from the bark of the cinchona tree, is an anti-malaria agent and a potassium channel inhibitor that inhibits mSlo3 (KCa 5.1) channel currents evoked by voltage pulses to +100 mV with IC50 of 169 μM.|
|S4490||Tetracycline||Tetracycline (TC) is a broad-spectrum antibiotic that exhibits activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites.|
|S3590||Triolein||Triolein is an inhibitor of metalloproteinase-1 (MMP-1) and reduces both the expression of IL-6 and ROS generation in irradiated keratinocytes.|
|S4713||Atropine||Atropine (Atropen, Atnaa, Tropine tropate, DL-Hyoscyamine) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect.|
|S5193||L-Thyroxine sodium salt pentahydrate||L-Thyroxine (Levothyroxine, L-T4) sodium salt pentahydrate is a synthetic T4 hormone used to counterbalance hypothyroidism.|
|S5260||ATP||ATP (Adenosine-Triphosphate, Adenosine 5'-triphosphate) is a multifunctional nucleoside triphosphate and an important endogenous signaling molecule in immunity and inflammation.|
|S5790||Folinic acid||Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).|
|S6466||Eicosapentaenoic acid ethyl ester||Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.|
|S4979||Procaine penicillin G||Penicillin G Procaine (PGP, Penicillin G Procaine, Bicillin C-R), a crystalline complex combining penicillin G with procaine, is a β-lactam antibiotic.|
|S5922||L-Carnitine hydrochloride||L-Carnitine ((R)-Carnitine, Levocarnitine) hydrochloride improves oxygen saturation, and inhibits leukotriene synthesis. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation.|
|S0911||Hypaphorine||Hypaphorine which is abundantly found in vaccaria semen, counteracts inflammation via inhibition of ERK or/and NFκB signaling pathways.|
|S4857||L-Ornithine||L-ornithine ((S)-2,5-Diaminopentanoic acid) has an antifatigue effect by increasing the efficiency of energy consumption and promoting the excretion of ammonia. It is one of the key reactants in the urea cycle.|
|S3578||Pyrroloquinoline quinone||Pyrroloquinoline quinone (PQQ, Methoxatin) is a natural anti-oxidant with anti-oxidative and anti-aging effects. Pyrroloquinoline quinone prevents estrogen deficiency-induced osteoporosis.|
|S4496||Maltose monohydrate||Maltose (Maltobiose, Malt Sugar, Beta-Maltose, D-Maltose) monohydrate, an non-essential nutrient that provides energy, is an intermediate in the intestinal digestion of glycogen and starch, and is found in germinating grains (and other plants and vegetables).|
|S9631||Puromycin aminonucleoside||Puromycin aminonucleoside (NSC 3056, PAN, Stylomycin aminonucleoside, ARDMA, SAN), the aminonucleoside portion of the antibiotic puromycin, is a reversible inhibitor of dipeptidyl-peptidase II and cytosol alanyl aminopeptidase that induces apoptosis in mesangial cells (MCs) accompanied by declined cell viability and enhanced inflammatory response.|
|S7428||Rocaglamide||Rocaglamide (Roc-A), isolated from Aglaia species, is a potent inhibitor of heat shock factor 1 (HSF1) activation with IC50 of ~50 nM for HSF1. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also inhibits NF-κB activity. Rocaglamide exhibits anti-tumor activity.|
|S3569||Spermidine||Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy.|
|S4438||Benzophenone||Benzophenone (Diphenyl ketone, Benzoylbenzene) filters out both UVA and UVB rays and is widely used in a great variety of sunscreens and personal care products.|
|S4440||2-Phenylacetamide||2-Phenylacetamide, the main compound isolated from the seeds of Lepidium apetalum Willd (LA) with estrogenic activities, increases the expression of Estrogen receptorα (ERα), ERβ and GPR30 in the uterus and MCF-7 cells.|
|S4425||Rifamycin S||Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation.|
|S4436||Pleuromutilin||Pleuromutilin (Drosophilin B, Mutilin 14-glycolate), the lead compound for novel antibiotics, inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria.|
|S4494||Methionine||Methionine (MRX-1024, D-Methionine) is an activitor of GABAA receptor that modulates neuronal activity.|
|S3588||Hexylene glycol||Hexylene glycol (HG, 2-Methyl-2,4-pentanediol, MPD) is an oxygenated solvent derived from acetone that has been used widely in industrial chemicals and cosmetics. Hexylene glycol exhibits antibacterial and antifungal properties.|
|S3595||D-Gluconic acid||D-Gluconic acid is an antifungal agent.|
|S6446||Sodium citrate dihydrate||Sodium citrate dehydrate (Trisodium citrate dihydrate, Citric acid trisodium salt dihydrate) is the preferred anticoagulant.|
|S3594||Adipic acid||Adipic acid (Hexanedioic acid) is an important dicarboxylic acid used for the manufacture of nylon and polyurethane plastics.|
|S3596||Polyvinylpyrrolidone||Polyvinylpyrrolidone (PVP, Polyvidone, Povidone) is an inert, water-soluble, non-toxic, temperature-resistant, pH-stable, biocompatible, biodegradable polymer that helps to encapsulate and cater both hydrophilic and lipophilic drugs. Polyvinylpyrrolidone has been widely tested and used as an effective wound healing accelerator.|
|S3598||Sucrose||Sucrose (D-(+)-Saccharose), a common sugar produced naturally in plants, is a disaccharide, a molecule composed of two monosaccharides:glucose and fructose.|
|S4424||Hyaluronidase||Hyaluronidase (Hyaluronate 4-glycanohydrolase, Hyaluronoglucosaminidase, Amphadase, Hydase, Vitrase) is a naturally occurring enzyme that degrades hyaluronic acid, which constitutes an essential part of the extracellular matrix.|
|S0235||Lavendustin B||Lavendustin B inhibits HIV-1 integrase (IN) interaction with its cognate cellular cofactor lens epithelium-derived growth factor (LEDGF/p75). Lavendustin B is an inhibitor of Tyrosine Kinase and also a competitive inhibitor of glucose transporter 1 (Glut1).|
|S9794||Melittin||Melittin (MLT, Forapin, Forapine) is an activator of phospholipase A2 (PLA2) that stimulates the activity of the low molecular weight PLA2, while it does not the increase the activity of the high molecular weight enzyme.|
|S3168||cis-Resveratrol||cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.|
|S3499||Monocaprylin||Monocaprylin (2,3-dihydroxypropyl octanoate, Monoctanoin, 1-Octanoyl-rac-glycerol, MC) exhibits an excellent antibacterial activity against Staphylococcus aureus and Escherichia coli.|
|S0921||Wilforine||Wilforine (WR), a sesquiterpene pyridine alkaloid found in T. wilfordii plants, significantly inhibits the efflux activity of P-glycoprotein (P-gp).|
|S3351||Sodium phenylpyruvate||Sodium phenylpyruvate (Phenylpyruvic acid sodium salt) inhibits amino acid formation and depresses oxygen consumption.|
|S2995||4-Hydroxyphenylpyruvic acid||4-Hydroxyphenylpyruvic acid (4-HPPA), an abundant colon metabolite of polyphenols, is a potent scavenger that suppresses levels of free radicals and cyclooxygenase-2 (COX-2) and contributes to reduced risk of colon cancer development.|
|S6918||Oleandrin (PBI-05204)||Oleandrin (PBI-05204, Foliandrin, Neriolin, Neriostene, Folinerin, Corrigen, Neriol) is an inhibitor of Na+/K+-ATPase with IC50 of 0.62 μM. Oleandrin induces apoptosis and reduces migration of human glioma cells in vitro.|
Phytohemagglutinin (PHA, Phaseolus vulgaris agglutinin) is expressed in Pichia pastoris using native signal peptides, or the Saccharomyces alpha-factor preprosequence, to direct proteins into the secretory pathway. Phytohemagglutinin induces apoptosis in human HEp-2 carcinoma cells via increasing proapoptotic protein Bax and activating caspases-3.
|P1201||LL37 (Human cathelicidin)||LL37 (Human cathelicidin, Ropocamptide) is a cathelicidin-related antimicrobial peptide with potent chemotactic and immunomodulatory properties.|
|S3069||Deoxycholic acid sodium salt||
Deoxycholic acid sodium salt (Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA) is specifically responsible for activating the TGR5 receptor (GPCR19) that stimulates brown adipose tissue (BAT) thermogenic activity.
2'-Deoxyadenosine 5'-monophosphate (5'-dAMP), an endogenous metabolite, is only photosensitized degraded under acidic conditions.
2'-Deoxycytidine-5'-monophosphoric acid (dCMP) is an endogenous metabolite that can be used as a model to describe mechanisms of DNA-strand breaks induced by secondary electrons and decomposes primarily by dissociation of the C-O phosphoester bond.
N-Acetyl-L-arginine (Ac-Arg-OH) dihydrate is an endogenous metabolite.
Levoglucosan (LG, LEV, Leucoglucosan, Glucosan, 1,6-anhydro-b-D-Glucose) is an endogenous metabolite.
Sodium 2-(1H-indol-3-yl)acetate (3-Indoleacetic acid sodium, Indole-3-acetic acid sodium, 3-IAA sodium) is an endogenous metabolite.
|S3326||Phytic acid dipotassium salt||
Phytic acid dipotassium salt (Phytic acid potassium, IP6 (PS)), an endogenous metabolite in rice grain extract and digest, inhibits β-secretase 1 (BACE1) with IC50 of approximately 0.25 μM.
2-Aminoethylphosphonic acid (2-AEP, (2-Aminoethyl)phosphonic acid) is a type of abundant and ubiquitous naturally occurring phosphonate used as sources of phosphorus by many prokaryotic lineages.
|S3335||Phospho(enol)pyruvic acid monopotassium salt||
Phospho(enol)pyruvic acid monopotassium salt (Potassium 1-carboxyvinyl hydrogenphosphate) is an endogenous metabolite.
Methyl β-D-Galactopyranoside (Methyl beta-D-galactoside, Methylgalactoside) is an endogenous metabolite.
3-Methoxytyramine (3-O-methyl Dopamine, 3MT) hydrochloride, a major extracellular metabolite of dopamine, is a neuromodulator that in certain situations may be involved in movement control.
|S3310||D-(+)-Galacturonic acid monohydrate||
D-(+)-Galacturonic acid monohydrate (D-Galacturonic acid hydrate, d-GalA, D-galUA) is an endogenous metabolite that can be used in engineering Saccharomyces cerevisiae.
2-Hydroxyhexanoic acid (2-Hydroxyhexanoic acid) is an endogenous metabolite.
DL-Tartaric Acid (2,3-Dihydroxysuccinic acid) is a white, crystalline organic acid isolated from many plants, particularly tamarinds and grapes and is used as an antioxidant and an additive agent to give a sour taste.
N-Acetyl-DL-methionine is an active endogenous metabolite that decreases the hepatic glutathione level in male Bom:NMRI mice.
|S3092||Glyoxylic acid monohydrate||
Glyoxylic acid monohydrate (2,2-Dihydroxyacetic acid) is an atmospherically relevant ketoacid.
Pyrazole (1H-pyrazole) is a five membered heteroaromatic ring with two nitrogen atoms is of immense significance. Pyrazole is an indispensable anchor for design and development of new pharmacological agents.
N-Acetyl-L-alanine (NAAL, Ac-Ala-OH) is an active endogenous metabolite.
3-Hydroxybenzaldehyde (3-HBA), one of the benzaldehydes commonly found in nature, is produced by 3-hydroxybenzyl-alcohol dehydrogenase, and is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans (ALDH2). 3-Hydroxybenzaldehyde exhibits vasculoprotective effects.
6-Hydroxyindole (1H-indol-6-ol) is an endogenous potent and long-lasting OATP1B1 inhibitor with IC50 of ~10 μM.
Glycolaldehyde dimer (2,5-Dihydroxy-1,4-dioxane, 1,4-Dioxane-2,5-diol, DD) is an active endogenous metabolite that appears moderate absorbent and fluorescent, when it reacts with glycine (Gly)/ammonium sulfate (AS).
Heptadecanoic acid (C17:0), an odd chain saturated fatty acid, significantly inhibits cell proliferation, and migration, while promoting apoptosis in PC‑9 and PC‑9/GR cells. Heptadecanoic acid is associated with several diseases, including the incidence of coronary heart disease, prediabetes and type 2 diabetes as well as multiple sclerosis.
D-(-)-Lyxose (D-Lyxose) is an active endogenous metabolite.
Nα-Acetyl-L-lysine (Ac-Lys-OH, N(alpha)-Acetyllysine) is an active endogenous metabolite.
3-Methylglutaric acid (MGA, 3MG acid) is a conspicuous C6 dicarboxylic organic acid that can be used as a single solid-state NMR standard compound to perform all calibration steps except for magnet shimming.
O-Acetyl-L-serine (OAS, O-Acetylserine, O-Acetyl-L-serine) hydrochloride (HCl) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants that displays a signalling function leading to changes in transcript levels of a specific gene set irrespective of the sulfur status of the plant.
4-Acetamidobutanoic acid (N-acetyl GABA) is a derivative of Gamma-aminobutyric acid (GABA) resulting from the monoacetylation of the nitrogen of GABA.
Bis(2-ethylhexyl) phthalate (Dioctyl phthalate, DOP, Diplast O, ESBO-D 82, Ergoplast FDO, Ergoplast FDO-S, Etalon) induces DNA strand breaks and gene expression alterations in larval zebrafish Danio rerio.
Itaconic acid, a macrophage-specific (Mϕ-specific) metabolite, mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid is also a precursor of polymers, chemicals, and fuels that can be synthesized by many fungi.
|S3096||L-Histidine monohydrochloride monohydrate||
L-Histidine monohydrochloride monohydrate (L-Histidine hydrochloride hydrate, H-His-OH.HCl.H2O), a structural analogue of the essential amino acid L-histidine, is a reversible inhibitor of protein biosynthesis which evokes disparate responses from non-tumorigenic and tumorigenic cells in culture.
N-Acetylglycine (NAGly, Aceturic acid, Acetamidoacetic acid), a minor constituent of numerous foods, is not genotoxic or acutely toxic.
5,6-Dimethylbenzimidazole (5,6-DMB, Dimezol, Dimedazol, 5,6-Dimethyl-1H-benzo[d]imidazole, 5,6-Dimethyl-1H-benzimidazole) is a vitamin B12 precursor.
D-Pyroglutamic acid (D-5-Oxoproline, D-Pyr-OH, 5-oxo-D-proline, (R)-5-Oxopyrrolidine-2-carboxylic acid) is an active endogenous metabolite that antagonizes the disruption of passive avoidance behaviour induced by the N-methyl-D-aspartate receptor antagonist AP-5.
N-acetyl-L-leucine is an active endogenous metabolite that accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus.
Pyridoxal hydrochloride (HQ) is an active endogenous metabolite.
(S)-(-)-1-Phenylethanol ((S)-1-Phenylethanol, (S)-(-)-Phenylethanol) is an enantiomer of 1-Phenylethanol with flavor properties.
|S3366||Monoethyl malonic acid||
Monoethyl malonic acid (Ethyl hydrogen malonate, Monoethyl malonate, 3-Ethoxy-3-oxopropanoic acid) is the major urinary metabolites of ethyl 3-ethoxypropionate (EEP).
(R)-3-Hydroxybutanoic acid (R-3HB, D-3-hydroxybutyric acid) is a monomer of PHB (poly[(R)-3-hydroxybutyrate]) with wide industrial and medical applications. (R)-3-hydroxybutyric acid can also serve as chiral precursor for synthesis of pure biodegradable PHB and its copolyesters.
Calcium 2-hydroxy-4-(methylthio)butanoate is an active endogenous metabolite.
2-Amino-1-phenylethanol (2-APE) is a noradrenaline analogue.
|S3221||Thymidine 5'-monophosphate disodium salt||
Thymidine-5'-monophosphate (5'-Thymidylic acid) disodium salt is an active endogenous metabolite.
Myosmine is not only one of the minor tobacco alkaloids but is also present in various foods. Myosmine has low affinity against a4b2 nicotinic acetylcholinergic receptors (nAChR) with Ki of 3300 nM.
N-Methylnicotinamide (MNA, Nicotinyl Methylamide, N-Methyl-3-pyridinecarboxamide) is an active endogenous metabolite that improves endothelial dysfunction and attenuates atherogenesis via the modulation of ADMA-DDAH axis.
|S3325||L-Cysteic acid monohydrate||
L-Cysteic acid monohydrate (CAM) is an active endogenous metabolite.
(L)-Dehydroascorbic acid (DHA) is an oxidized form of l-Ascorbic acid (AsA) that efficiently scavenges non-thermal plasma-induced hydroxyl radicals in the presence of thiols and fails to scavenge hydroxyl radicals by itself.
Petroselinic acid (PSA) is a positional isomer of oleic acid isolated from the vegetable oil of Coriandrum sativum fruits. Petroselinic acid can be used for the fermentation of new sophorolipids.
|S3344||Serotonin creatinine sulfate monohydrate||
Serotonin (5-Hydroxytryptamine) creatinine sulfate monohydrate is an active endogenous metabolite.
1-Methylnicotinamide (1-MNA, 3-Carbamoyl-1-methylpyridin-1-ium, Trigonellamide) chloride is an active endogenous metabolite of nicotinamide that exhibits anti-inflammatory and anti-thrombotic activities. 1-Methylnicotinamide enhances tumor vasculature formation and markedly increases prostacyclin (PGI2) generation.
|S3349||Phosphocholine chloride calcium salt tetrahydrate||
Phosphocholine (Phosphorylcholine) chloride calcium salt tetrahydrate is an active endogenous metabolite.
Cholesteryl linoleate is less polar lipid in human nasal fluid that contributes to the inherent antibacterial activity.
Tricosanoic acid is an aliphatic carboxylic acid that exhibits a strong hair-growing effect.
|S3353||Lithium acetoacetate||Lithium acetoacetate (LiAcAc, Acetoacetic acid lithium salt, Lithium 3-oxobutanoate) is an active endogenous metabolite that affects the growth of cells. Lithium acetoacetate can be used as an acetoacetate standard for the measurement of acetoacetate in biological samples.|
|S3354||DL-2,3-Diaminopropionic acid monohydrochloride||
DL-2,3-Diaminopropionic acid monohydrochloride (2,3-Diaminopropanoic acid hydrochloride) is an active endogenous metabolite.
3-Hydroxyanthranilic Acid (3-HAA, 3-HANA), a tryptophan metabolite, has an immunomodulatory effect that may result from inhibition of PI3K/Akt/mTOR and NF-κB activity, thereby decreasing the production of pro-inflammatory mediators.
Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.
Elaidic acid is a major trans fatty acid that inhibits cell viability, elevates cell apoptosis by enhancing oxidative stress. Elaidic acid can be used as a pharmaceutical solvent.
Isomaltulose (Palatinose) hydrate is a disaccharide carbohydrate widely used during exercise to maintain glycaemia and hydration.
(3-Carboxypropyl)trimethylammonium chloride (γ-Butyrobetaine, γBB hydrochloride) is an intermediary metabolite by gut microbes from dietary L-carnitine in mice.
|S3362||D-Gulonic acid γ-lactone||D-Gulonic acid γ-lactone (Gulonolactone, D-Gulono-1,4-lactone, 1,4-D-Gulonolactone) is an active endogenous metabolite.|
cis-4-Hydroxy-D-proline (H-D-cis-Hyp-OH) is an endogenous metabolite that can be used to study the specificity and kinetics of D-alanine dehydrogenase.
|S3368||Uridine-5'-diphosphate disodium salt||
Uridine-5'-diphosphate (UDP) disodium salt is a potent, selective and natural agonist of P2Y6 receptor with EC50 = 300 nM and pEC50 of 6.52, respectively. Uridine-5'-diphosphate (UDP) disodium salt is also an antagonist of P2Y14 receptor with pEC50 of 7.28.
N-Acetyl-D-mannosamine (ManNAc, N-acetyl-beta-mannosamine), a precursor of a sialic acid, improves the age-dependent attenuation of synaptic transmission and long-term potentiation (LTP). N-Acetyl-D-mannosamine treatment is a potential therapeutic application for cognitive dysfunction.
(±)-Methyl Jasmonate (MeJA, Methyl jasmonate, Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate), a phytohormone that acts as a vital cell regulator in plants, is a new candidate for the treatment of Inflammatory bowel diseases (IBDs), modulating the expression of the major classes of caspase-type protease families.
|S3169||2'-Deoxyuridine 5'-monophosphate disodium salt||
2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.
Nicotinuric acid (NUA) is the major detoxification product of nicotinic acid and may serve as a simple quantitative index of hepatic biotransformation of nicotinic acid.
D-Mannosamine hydrochloride ((2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride) is an active endogenous metabolite.
3-Hydroxyphenylacetic acid (3-HPAA) is a phenolic acid mostly found in olive oil wastewater and an intestinal metabolite of the dietary flavonoid quercetin. 3-Hydroxyphenylacetic acid exhibits antimicrobial properties.
|S3040||Isocitric acid trisodium salt||
Isocitric acid (DL-Isocitric acid) trisodium salt is an active endogenous metabolite.
12-Hydroxydodecanoic acid (G12) is an active endogenous metabolite.
Palmitoleic acid (POA, Palmitoleate) stimulates the uptake of glucose in liver through activation of AMPK and FGF-21, dependent on PPARα.
Nα-Acetyl-L-asparagine (N-Acetylasparagine, (S)-2-acetamido-4-amino-4-oxobutanoic acid) is an endogenous metabolite that exists in human brain.
|S2991||Thiamine monophosphate chloride dihydrate||
Thiamine monophosphate chloride dihydrate (Vitamin B1 Monophosphate Chloride, Sineurina, Phosphothiamine) is an endogenous metabolite.
|S2992||Sodium mesoxalate monohydrate||
Sodium mesoxalate monohydrate (sodium 2,2-dihydroxymalonate) is an endogenous metabolite.
|S2993||D-Saccharic acid potassium salt||
D-Saccharic acid potassium salt (D-Glucaric acid potassium, Potassium bisaccharate) is an endogenous metabolite.
|S2999||Acetic acid octyl ester||
Acetic acid octyl ester (Octyl acetate) is one of the major components of essential oils in the vittae, or oil tubes, of the wild parsnip (Pastinaca sativa). Acetic acid octyl ester exhibits antioxidant activity.
Methyl isoeugenol (Methylisoeugenol) is an eugenol analogue isoeugenol isolated from Acori Tatarinowii Rhizoma. Methyl isoeugenol is a highly attractive lure for Z. diversus and would be a valuable inclusion as an attractant in monitoring and male annihilation programs.
Menthone is one of the main volatile components of the essential oil of peppermint (Mentha piperita L.). Menthone is used as antioxidant agent and has a good compensatory effect with significant reduction in DNA damages in sperm cells.
Methyl acetylacetate (MAA, Acetoacetate methyl ester, Methyl 3-oxobutanoate, Methyl 3-oxobutyrate, Methyl acetoacetate, Methyl acetylacetate), an endogenous metabolite, is used as a chemical reagent used in the synthesis of pharmaceuticals.
Isophorone (IPHO), an α,β-unsaturated cyclic ketone, is a clear liquid with a camphor-like odor. Isophorone is used as a precursor to polymers.
Nudifloric acid (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid), isolated from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities.
Cis-3-Hexenyl hexanoate ((Z)-3-hexenyl hexanoate) is a kind of plant volatile that brings tropical and pulpy profile with citrus and green nuances to all kinds of fruit flavors.
|S3327||Disodium 5'-inosinate monohydrate||
Disodium 5'-inosinate monohydrate (Inosine 5'-monophosphate disodium salt hydrate) is an endogenous metabolite.
(2R,3R)-(-)-2,3-Butanediol ((2R,3R)-Butane-2,3-diol) is an endogenous metabolite.
|S2990||Dihydroxyfumaric acid hydrate||
Dihydroxyfumaric acid hydrate (DHF) is an endogenous metabolite. The diester derivative of dihydroxyfumaric acid hydrate (DHF) has been used exclusively as an electrophile in organic synthesis.
DL-5-Hydroxylysine hydrochloride, an endogenous metabolite, is a racemic mixture of D- and L- enantiomers of 5-hydroxylysine which may be used as potential target markers for radical-induced protein oxidation.
DL-Homocysteine is a weak neurotoxin that affects the production of kynurenic acid (KYNA) in the brain. DL-Homocysteine inhibits the activity of both KYNA biosynthetic enzymes, kynurenine aminotransferases (KATs) I and II.
δ-Valerolactone (Tetrahydro-2H-pyran-2-one, 5-Valerolactone, oxan-2-one) is an endogenous metabolite.
N-Formyl-L-methionine (For-Met-OH) is an endogenous metabolite.
|S6955||Insulin (human)||Insulin (human) (Insulin regular) is a polypeptide hormone that regulates the level of glucose. Insulin is commonly used to treat hyperglycemia in patients with diabetes. Potency: 29 units/mg.|
9-Methoxycanthin-6-one is present in intact plant parts and in callus tissues of different explants with anti-tumour activity.
2,5-Dimethylpyrazine (NSC 49139) is an endogenous metabolite.
L-DAB HBR (L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide) is an inhibitor of GABA (Gamma-aminobutyric acid) transaminase with IC50 of >500 μM. L-DAB HBR exhibits antitumor activity.
Malonic acid (MOA), one of the major dicarboxylic acids (DCAs) in aerosols, has been identified experimentally and computationally to be a strong acid. Malonic acid (MOA) acts as a mediate bridge for the formation of pure SA-A-based clusters.
Maleic acid inhibits glutamate decarboxylase (GAD) activity, thus enhances acid sensitivity of Listeria monocytogenes. Maleic acid affects the extracellular GABA levels.
trans-Aconitic acid (TAA) is an abundant constituent in the leaves of Echinodorus grandiflorus, a medicinal plant used to treat rheumatoid arthritis in Brazil.
2-Deoxy-D-ribose (Thyminose, Deoxyribose) is an endogenous metabolite.
L-Homoserine (L-Hse) is an important biosynthetic intermediate of threonine, methionine and lysine.
3-Methyl-2-buten-1-ol (Prenol, Prenyl alcohol, Dimethylallyl alcohol) is an endogenous metabolite.
Pyruvic acid (Acetylformic acid) is an important organic chemical intermediate that plays a role in cardiomyocyte pathophysiology and therapy. Pyruvic acid markedly increases the level of lactate dehydrogenase (LDH) and creatine kinase (CK) and reduces the level of Ca2+Mg2+-ATPase and Na+K+-ATPase.
|S3084||Guanosine 5'-triphosphate trisodium salt||
Guanosine 5'-triphosphate (5'-GTP, Guanosine triphosphate, H4GTP) trisodium salt is an enhancer of myogenic cell differentiation in a murine cells. Guanosine 5'-triphosphate trisodium salt up-regulates miRNA (specifically miR133a and miR133b) and myogenic regulator factor and induces human myogenic precursor cells to release exosomes stuffed with guanosine based molecules (mainly guanosine) in the extracellular milieu.
N-Formylglycine (2-formamidoacetic acid, For-Gly-OH, FGly) is an endogenous metabolite.
Sodium 2-hydroxybutanoate (Sodium 2-hydroxybutyrate, Sodium DL-2-hydroxybutyrate), converted from 2-Aminobutyric acid, is an intermediate metabolite.
2,4-Dihydroxypyrimidine-5-carboxylic Acid (Uracil 5-carboxylic acid, Isoorotic acid, 5-Carboxyuracil) is an endogenous metabolite.
N-Acetyl-D-galactosamine (D-N-Acetylgalactosamine) is an endogenous metabolite.
L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose promotes food intake while cannot be used by cells as an energy source because it cannot be phosphorylated by hexokinase.
D-(-)-Tartaric acid is the unnatural isomer of Tartaric acid which is an important chiral chemical building block with broad industrial and scientific applications.
|S3141||Maleimide||Maleimide exhibits fluorescence quenching ability and can be used for the specific detection of thiol analytes as fluorogenic probes. Maleimide is also used for production of antibody-drug conjugate (ADC) which is used in cancer research.|
Potassium sorbate (Sorbic acid potassium) is a nonpoisonous food preservative isolated from Sorbus aucuparia. Potassium sorbate is an effective inhibitor of most molds and yeasts and some bacteria.
Pimelic acid (Heptanedioic acid, 1,5-Pentanedicarboxylic acid, 1,7-Heptanedioic acid) originating from fatty acid synthesis pathway is a bona fide precursor of biotin in B. subtilis.
Glutaric acid (GA) is an attractive C5 dicarboxylic acid with wide applications in the biochemical industry.
Citraconic acid (CA) is a kind of methyl-branched fatty acids that exists in wild soybean.
5-hydroxy-1-tetralone is a fluorescent labeling reagent for the determination of glycosphingolipid from small amounts of biological samples.
Maleamic acid ((Z)-4-Amino-4-oxobut-2-enoic acid) is an endogenous metabolite.
3-(2-Hydroxyphenyl)propanoic acid (Melilotic acid, Melilotate, 2-hydroxybenzenepropanoic acid) is an endogenous metabolite.
|S2987||4-Methyl-2-oxovaleric acid||4-Methyl-2-oxovaleric acid (Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate) is released by Astrocytes to neurons and can be reaminated by aminotransferase to leucine. 4-Methyl-2-oxovaleric acid reduces the rate of protein degradation in skeletal muscle. 4-Methyl-2-oxovaleric acid acts as an uncoupler of oxidative phosphorylation (OXPHOS) and as a metabolic inhibitor possibly through its inhibitory effect on alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrogenase complex, OGDC) activity.|
|S3266||L-Anserine nitrate salt||
L-Anserine nitrate salt, a dipeptide found in most animal tissues, exhibits antioxidant properties, anti-crosslinking, and anti-glycation activities. L-Anserine protects against neurotoxicity induced by ER-stress inducers.
Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. Amarogentin induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. Amarogentin (AG) interacts with the α2 subunit of AMP-activated protein kinase (AMPK) and activates the trimeric kinase with EC50 of 277 pM.
|S0923||Isoliquiritin apioside||Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.|
Adamantane is a colorless, crystalline chemical compound first isolated from petroleum with a camphor-like odor. Adamantane is used to treat influenza A virus infections.
|S9690||Caerulein (FI-6934)||Caerulein (Ceruletide, Cerulein, FI-6934), a cholecystokinin (CCK) receptor agonist, is a safe and effective cholecystokinetic agent and small bowel and exocrine pancreatic stimulant.|
|S6924||D-Luciferin sodium salt||D-Luciferin (D-(-)-Luciferin, Firefly luciferin) sodium salt is the natural substrate of luciferases that catalyze the production of light in bioluminescent insects.|
|S3290||Procyanidin B2||Procyanidin B2 (PCB2), a natural flavonoid found in commonly consumed foods, possess anti-inflammatory, anti-oxidant and anti-cancer activities. Procyanidin B2 activates PPARγ to induce M2 polarization in mouse macrophages. Procyanidin B2 significantly suppresses the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model.|
|S9700||Tapinarof||Tapinarof (GSK2894512, Benvitimod, WBI 1001, DHPS, DMVT 505) is a natural agonist of aryl hydrocarbon receptor (AhR) and induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) with EC50 of 0.16 nM. Tapinarof induces cellular apoptosis in CD4+ T cells in a dosedependent manner with IC50 of 5.2 μM.|
|S6919||Brevilin A||Brevilin A (6-O-Angeloylplenolina), a sesquiterpene lactone isolated from Centipeda minima, is a selective inhibitor of STAT3 and attenuates the JAKs activity by blocking the JAKs tyrosine kinase domain JH1. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation.|
|S0924||Pteryxin||Pteryxin ((+)-Pteryxin), a dihydropyranocoumarin derivative found in Apiaceae family, is a potent inhibitor of butyrylcholinesterase (BChE) with IC50 of 12.96 μg/ml. Pteryxin inhibits LPS-induced nitric oxide production in mouse peritoneal macrophages with IC50 of 20 µM. Pteryxin is potential for Alzheimer's disease (AD) treatment.|
|S0973||Wilforgine||Wilforgine, one of the major bioactive sesquiterpene alkaloids in Tripterygium wilfordii Hook. F., induces microstructural and ultrastructural changes in the muscles of M. separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system.|
|S3254||Plantagoside||Plantagoside, a flavanone glucoside isolated from the seeds of Plantago asiatica, is a specific and non-competitive alpha-mannosidase inhibitor with IC50 of 5 μM.|
|S3253||Xylobiose||Xylobiose (1,4-β-D-Xylobiose, 1,4-D-Xylobiose), a disaccharide of xylose monomers, is a natural substrate that can be hydrolysed by Beta-D-Xylosidase/alpha-L-arabinofuranosidase from Selenomonas ruminantium (SXA).|
|S3252||Xylotriose||Xylotriose (1,4-b-D-Xylotriose, 1,4-beta-D-xylotriose) is a natural xylooligosaccharide substrate that can be hydrolysed by catalytically efficient beta-D-xylosidase from Selenomonas ruminantium (SXA).|
|S3222||Raspberry ketone glucoside||Raspberry ketone glucoside (RKG), a natural product in raspberry fruit, is an antioxidant that has the inhibitory effect on the melanin synthesis.|
|S3223||L-Quebrachitol||L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.|
|S3226||Dehydroabietic acid||Dehydroabietic acid (DAA, DHAA), a naturally occurring diterpene resin acid derived from coniferous plants such as Pinus and Picea, displays anti-inflammatory activity via suppression of Src-, Syk-, and TAK1-mediated pathways.|
|S3278||Kaempferol-3-O-neohesperidoside||Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside), a flavonoid isolated from the leaf extract of Primula latifolia Lapeyr. and Primula vulgaris Hudson, stimulates glycogen synthesis in rat soleus muscle via PI3K - GSK-3 pathway and MAPK - PP1 pathway.|
|S3289||Daphnoretin||Daphnoretin (Dephnoretin, Thymelol), a biologically active compound isolated from Wikstroemia indica C.A. Mey., is a protein kinase C (PKC) activator. Daphnoretin inhibits the proliferation, invasion, and migration of tumor cells and promote its apoptosis by regulating the activity of Akt signal pathway.|
|S3295||Taxifolin 7-rhamnoside||Taxifolin 7-rhamnoside (TR, Taxifolin 7-O-rhamnoside, Taxifolin 7-O-α-L-rhamnoside), a flavonoid isolated from Hypericum japonicum, shows antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).|
|S3224||Cinobufagin||Cinobufagin (Cinobufagine), an active ingredient of Venenum Bufonis, inhibits tumor development. Cinobufagin increases ATM and Chk2 and decreases CDC25C, CDK1, and cyclin B. Cinobufagin inhibits PI3K, AKT and Bcl-2 while increases levels of cleaved caspase-9 and caspase-3. Thus, Cinobufagin induces cell cycle arrest at the G2/M phase and apoptosis.|
|S3230||L-Fucitol||L-Fucitol (1-Deoxy-D-galactitol), a galactitol analogue isolated from Myristica fragrans (Nutmeg), inhibits galactitol-positive strains of Escherichia coli K12.|
|S3233||Emetine hydrochloride||Emetine hydrochloride (NSC 33669), a principal alkaloid extracted from the root of ipecac clinically used as an emetic and antiprotozoal drug, reduces HIFs (hypoxia-inducible factors; HIF-1α and HIF-2α), PDK1, RhoA, Rho-kinases (ROCK1 and ROCK2) and BRD4. Emetine hydrochloride inhibits cellular autophagy and has anti-malarial, anti-viral, anti-bacterial and anti-amoebic effect.|
|S3236||Mesaconitine||Mesaconitine, one of the aconite alkaloids in Aconiti tuber, increases the [Ca2+]i level in endothelial cells by influx of Ca2+ from extracellular spaces.|
|S3238||Resibufogenin||Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.|
|S3245||Nodakenetin||Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.|
|S3251||Goitrin||Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) is one of the main constituent of Radix isatidis (Banlangen) which is widely used as a traditional Chinese medicine for treating fever and removing toxic heat. Goitrin exhibits antiviral and antiendotoxin activity.|
|S3262||Scopolin||Scopolin, a coumarin isolated from Arabidopsis thaliana (Arabidopsis), attenuates hepatic steatosis through activation of SIRT1-mediated signaling cascades, a potent regulator of lipid homeostasis.|
|S3267||Kaempferol-3-O-rutinoside||Kaempferol-3-O-rutinoside (Nicotiflorin, Nikotoflorin, Kaempferol 3-O-β-rutinoside), a flavonoid extracted from Carthamus tinctorius, alters the shape and structure of injured neurons, decreases the number of apoptotic cells, down-regulates expression of p-JAK2, p-STAT3, caspase-3, and Bax and decreases Bax immunoredactivity, and increases Bcl-2 protein expression and immunoreactivity.|
|S3271||Caudatin||Caudatin (Cauldatin), one species of C‑21 steroidal from Cynanchum auriculatum (C. auriculatum), effectively inhibits human glioma growth in vitro and in vivo through triggering cell cycle arrest and apoptosis.|
|S3273||Hypericin||Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).|
|S3291||Myristicin||Myristicin (Myristicine), a terpene-like active component in Nutmeg which is the seed of Myristica fragrans, is a weak inhibitor of monamine oxidase (MAO) and a mechanism-based inhibitor of CYP1A2.|
|S3296||Hispidulin||Hispidulin (Dinatin), an active natrual ingredient in a number of traditional Chinese medicinal herbs, exhibits inhibitory activity against the oncogenic protein kinase Pim-1 with IC50 of 2.71 μM. Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells. Hispidulin exerts anti-osteoporotic and bone resorption attenuating effects via activating the AMPK signaling pathway.|
|S3300||Desoxyrhaponticin||Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.|
|S3301||Cynarin||Cynarin (Cynarine) is an artichoke phytochemical that possesses a variety of pharmacological features including free-radical scavenging, antioxidant, antihistamic and antiviral activities. Cynarin blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. Cynarin triggers Nrf2 nuclear translocation, restores the balance of glutathione (GSH) and reactive oxygen species (ROS), and inhibits mitochondrial depolarization.|
|S3240||Phaseoloidin||Phaseoloidin, a homogentisic acid glucoside from Nicotiana attenuata trichomes, contributes to the plant's resistance against lepidopteran herbivores. Phaseoloidin has anti-complement effects.|
|S3242||Loureirin B||Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the KATP current, influx of Ca2+ to the intracellular.|
|S3246||Picfeltarraenin IB||Picfeltarraenin IB, a cucurbitacin glycoside isolated from Picriafel-terrae, is an inhibitor of acetylcholinesterase (AChE). Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation.|
|S3260||3'-hydroxy Puerarin||3'-hydroxy Puerarin is an isoflavone isolated from Puerariae Lobatae Radix.|
|S3264||Atractyloside potassium salt||Atractyloside potassium salt (ATR potassium salt), a toxic diterpenoid glycoside isolated from the fruits of Xanthium sibiricum (Cang'erzi), is a powerful and specific inhibitor of mitochondrial ADP/ATP carriers. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart.|
|S3269||Acetylcorynoline||Acetylcorynoline, a major alkaloid component derived from Corydalis bungeana which is a traditional Chinese medical herb, shows anti-inflammatory properties. Acetylcorynoline may decrease egl-1 expression to suppress apoptosis pathways and increase rpn5 expression to enhance the activity of proteasomes.|
|S3270||Genipin 1-O-beta-D-gentiobioside||Genipin 1-O-beta-D-gentiobioside (GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside) is a bioactive iridoid glycoside isolated from Gardenia jasminoides Ellis (Zhizi in Chinese) that exhibits hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.|
|S3275||Senkyunolide I||Senkyunolide I (SEI, SENI) is an orally active compound isolated from Ligusticum chuanxiong with analgesic, anti-migraine, neuroprotective, anti-oxidation and anti-apoptosis activities. Senkyunolide I (SEI, SENI) up-regulates the phosphorylation of Erk1/2 and induces Nrf2 nuclear translocation with enhanced HO-1 and NQO1 expressions. Senkyunolide I (SEI, SENI) promotes the ratio of Bcl-2/Bax and inhibits the expressions of cleaved caspase 3 and caspase 9.|
|S3297||Hosenkoside A||Hosenkoside A is a bioactive baccharane glycoside isolated from the seeds of impatiens balsamina.|
|S3303||Cyperotundone||Cyperotundone (CYT) is an active constituent in Chuanxiong Rhizoma and Cyperi Rhizoma (CRCR) for treating migraine.|
|S3307||Galangin 3-methyl ether||Galangin 3-methyl ether (3-O-Methylgalangin, 3-Methylgalangin), isolated from Lychnophora markgravii aerial parts, shows strong antibacterial and antifungal effects.|
|S3308||Caftaric acid||Caftaric acid (CA, Caffeoyl tartaric acid) is a natural product that shows anti-oxidant and anti-inflammatory effects.|
|S3276||Hosenkoside K||Hosenkoside K is a bioactive baccharane glycoside isolated from the seeds of impatiens balsamina.|
|S6906||Capric acid||Capric acid (DA, Decanoic acid, Decylic acid), a component of medium-chain triclycerides occurring naturally in coconut oil and palm kernel oil, contributes to seizure control through direct AMPA receptor inhibition. Capric acid is also a modulating ligand for PPARs. Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.|
|S6899||Licochalcone D||Licochalcone D (Lico D, LCD, LD), a flavonoid isolated from a Chinese medicinal plant Glycyrrhiza inflata, has antioxidant, anti-inflammatory and anti-cancer properties. Licochalcone D inhibit phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone D inhibits JAK2, EGFR and Met (c-Met) activities and induces ROS-dependent apoptosis. Licochalcone D also induces caspases activation and poly (ADP-ribose) polymerase (PARP) cleavage.|
|S3265||9''-Methyl salvianolate B||9''-Methyl salvianolate B (9'-methyllithospermate B, 9'-Methyl lithospermate B, 9'''-Methyl salvianolate B) is an active constituent in ethanol extract of Radix Salviae Miltiorrhizae.|
|S6885||Ailanthone||Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27. Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway. Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively.|
|S0917||Allosecurinin||Allosecurinine (Phyllochrysine) is a Securinega alkaloid isolated from M.indica and M.discoidea with antifungal activity.|
|S0906||6-Methoxydihydroavicine||6-Methoxydihydroavicine (6-Methoxy Dihydrosanguinarine) is an lkaloid isolated from the fruits of M.cordata.|
|S3288||Absinthin||Absinthin (Absynthine) is a naturally produced triterpene lactone from Artemisia absinthium with anti-inflammatory properties. Absinthin significantly enhances the expression of matrix metalloproteinase-8 (MMP-8) and is a possible treatment candidate for Acute lung injury (ALI).|
|S3287||Rosamultin||Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis.|
|S6340||Guanidinoacetic acid||Guanidinoacetic acid (Guanidino acetic acid, GAA, Glycocyamine, Guanidinoacetate), the natural precursor of creatine, is under investigation as a dietary agent. Guanidinoacetic acid exhibits potential ergogenic benefits for physically active men and women.|
|S3220||Trigonelline||Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.|
|S3235||Sinapine||Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.|
|S3261||Myrislignan||Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibits interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) dose-dependently in LPS-stimulated macrophage cells. Myrislignan inhibits the NF-κB signalling pathway activation.|
|S3279||Polyphyllin B (Formosanin C)||Polyphyllin B (Formosanin C, FC), a diosgenin saponin isolated from Paris formosana, is an immunomodulator with antitumor activity. Polyphyllin B (Formosanin C, FC) induces apoptosis.|
|S3280||Linderene||Linderene (Lindenenol) is a furanosesquiterpenoid isolated from Lindera pulcherrima with antibacterial and antioxidant activities.|
|S3281||Quercetin 3-O-β-D-glucose-7-O-β-D-gentiobioside||Quercetin 3-O-β-D-glucose-7-O-β-D-gentiobioside (Quercetin 3-O-β-D-glucose-7-O-β-D-gentiobiosiden, Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside) is an active constituent of Descurainiae Semen.|
|S3298||Caulophylline (N-Methylcytisine)||Caulophylline (N-Methylcytisine, Caulophyllin, NMC) is a tricyclic quinolizidine alkaloid with anti-inflammatory activities. Caulophylline binds to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia with Kd of 50 nM. Caulophylline significantly reduces myeloperoxidase (MPO) activity, blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation.|
|S3302||β,β-dimethyl-acryl-alkannin||β,β-dimethyl-acryl-alkannin (AN-I, β,β-Dimethylacrylalkannin) is a napthoquinone isolated from roots of Arnebia nobilis Reichb.f. that has the potential to be used as an anti-aging ingredient.|
|S3304||Stylopine||Stylopine ((R,S)-Stylopine, Tetrahydrocoptisine) reduces nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation. Stylopine is a major component of the leaf of Chelidonium majus L.|
|S3306||1,1,1,1-Kestohexaose||1,1,1,1-Kestohexaose is a major DP 6 fructan in crested wheatgrass leaves.|
|S3205||Perillaldehyde||Perillaldehyde (Perilladehyde, Perillal, PAE, PA), the main component of Perilla frutescens (a traditional medicinal antioxidant herb), inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway.|
|S3227||5,7-Dimethoxyflavone||5,7-Dimethoxyflavone (5,7-DMF) is an inhibitor of cytochrome P450 (CYP) 3As that markedly decreases the expression of CYP3A11 and CYP3A25 in the liver. 5,7-Dimethoxyflavone (5,7-DMF) is also a potent Breast Cancer Resistance Protein (BCRP, ABCG2) inhibitor. 5,7-Dimethoxyflavone (5,7-DMF) is one of the major components of Kaempferia parviflora with anti-obesity, anti-inflammatory, and antineoplastic effects.|
|S3237||Deoxyaconitine||3-Deoxyaconitine is a diterpenoid alkaloid isolated from the root of Aconitum Carmichaeli Debx.|
|S3241||Loureirin A||Loureirin A is a flavonoid extracted from the red resin of the herbs of Dracaena cochinchinensis, which is known as Dragon's Blood. Loureirin A inhibits platelet activation by an impairment of PI3K/Akt signaling. Loureirin A inhibits Akt phosphorylation.|
|S3247||Icariside I||Icariside I (Icarisid I) is one of the main components in Epimedii Folium that significantly stimulates cell proliferation and osteoblasts differentiation.|
|S3249||Corypalmine||Corypalmine ((R)-(+)-Corypalmine), an alkaloid isolated from Stephania cepharantha, is an inhibitor of prolyl endopeptidase/oligopeptidase (PREP/POP) with IC50 of 128.0 μM.|
|S3255||Pectolinarigenin||Pectolinarigenin, an active anti-inflammatory ingredient in Cirsium chanroenicum, is a dual inhibitor of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX).|
|S3256||Tectochrysin||Tectochrysin (Techtochrysin, NSC 80687) is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin significantly increases the expression of DR3, DR4 and Fas and inhibits activity of NF-κB. Tectochrysin induces apoptotic cell death.|
|S3257||Rebaudioside B||Rebaudioside B (Reb B) is one of the minor steviol glycosides (SGs) isolated from Stevia rebaudiana and has a better taste quality than many of the major SGs.|
|S3259||Rebaudioside D||Rebaudioside D (Reb D) is one of the several glycosides (SGs) found in the leaves of Stevia rebaudiana (Bertoni) which has been identified as a potential sweetener.|
|S3272||Steviol (Hydroxydehydrostevic acid)||Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902), a major metabolite of the sweetening compound stevioside, inhibits CFTR activity, reduces AQP2 expression and promotes AQP2 degradation.|
|S3274||Glucosyl-vitexin||Glucosyl-vitexin (Glucosylvitexin), the major C-glycosylflavone present in millet, inhibits thyroid peroxidase (TPO) activity.|
|S3282||Rebaudioside M||Rebaudioside M, isolated from Stevia rebaudiana Bertoni, is a natural non-caloric potential sweetener in food and beverage products.|
|S3283||Marmesin||Marmesin (S-(+)-Marmesin, (+)-Marmesin, (S)-Marmesin) is a natural coumarin with COX-2 and 5-LOX dual inhibitory activity.|
|S3284||Tracheloside||Tracheloside is a lignan glycoside isolated from seeds of Carthamus tinctorius with anti-estrogenic effects. Tracheloside significantly decreases the activity of alkaline phosphatase (AP) (an estrogen-inducible marker enzyme) with IC50 of 0.31 μg/ml. Tracheloside promotes keratinocyte proliferation through ERK1/2 stimulation.|
|S3285||Dihydrolycorine||Dihydrolycorine is a derivative of lycorine, an alkaloid isolated from Lycoris radiata Herb. Dihydrolycorine blocks protein synthesis in ascites cells and stabilize HeLa cell polysomes in vivo. Dihydrolycorine exhibits antihypertensive and neuroprotective activities.|
|S3299||Demethyleneberberine||Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways.|
|S0553||Butyl isobutyl phthalate||Butyl isobutyl phthalate (BIP), isolated from the rhizoid of Laminaria japonica, is a non-competitive inhibitor of α-glucosidase with IC50 of 38 μM. Butyl isobutyl phthalate displays a significant hypoglycemic effect and has the potential for diabetes treatment.|
|S3206||5a-Pregnane-3,20-dione||5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) is the endogenous progesterone metabolite. 5a-Pregnane-3,20-dione depolymerizes actin and decreases expression of actin and vinculin. 5a-Pregnane-3,20-dione is involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules.|
|S2440||Vindesine sulfate||Vindesine sulfate (Eldesine, Eldisine, Desacetyl Vinblastine amide, Desacetylvinblastine amide, DAVA, DVA, VDS), a vinca alkaloid derived from Catharanthus roseus, is a potent inhibitor of mitosis with antineoplastic activities. Vindesine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.|
|S0949||Cucurbitacin IIb||Cucurbitacin IIb (CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A) inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB, blocks nuclear translocation of NF-κB and decreases mRNA levels of IκBα and TNF-α. Cucurbitacin IIb exhibits anti-inflammatory activity and induces apoptosis. Cucurbitacin IIb is isolated from Hemsleya amabilis.|
|S6852||Gossypol||Gossypol (BL 193) is an orally-active polyphenol isolated from cotton seeds and roots. Gossypol is a potent inhibitor of 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase with IC50 of 3.33 μM and 0.52 μM in cell-free assay, respectively. Gossypol also inhibits the binding of BH3 peptide to Bcl protein with IC50 of 0.4 μM and 10 μM for Bcl-XL and Bcl-2, respectively. Gossypol induces apoptosis and cell growth inhibition in various cancer cells.|
|S3210||3'-Hydroxy-4'-methoxyacetophenone||3'-Hydroxy-4'-methoxyacetophenone (Acetoisovanillone, Isoacetovanillone, Diosmin EP Impurity A) is an active P. spinosa extract with anti-inflammatory potential.|
|S3213||Veratryl alcohol||Veratryl alcohol (VA, Veratrole alcohol, 3,4-Dimethoxybenzyl alcohol), a secondary metabolite of some lignin degrading fungi, is the natural substrate of Lignin peroxidase (LiP).|
|S3214||Veratraldehyde (3,4-Dimethoxybenzaldehyde)||Veratraldehyde (3,4-dimethoxybenzaldehyde, VD, VAD, VAld, Verapamil Related Compound E, Methylvanillin), a derivative of vanillin, is the chemical that is found and isolated from peppermint, ginger, bourbon vanilla, and fruits such as raspberry. Veratraldehyde is widely used as a flavorant and odorant because of its pleasant woody fragrance. Veratraldehyde also acts as a redox cycle agent.|
|S3215||2-O-α-D-Glucopyranosyl-L-ascorbic acid||2-O-α-D-Glucopyranosyl-l-ascorbic acid (AA-2G), which is a glucoside derivative of ascorbic acid (AA), shows vitamin C activity after enzymatic hydrolysis to ascorbic acid. The antitumor activity of AA-2G is caused by ROS generated by AA released by rapid hydrolysis of AA-2G.|
|S3203||D-Alanine||D-alanine (Ala, (R)-Alanine, Ba 2776, D-α-Alanine, NSC 158286) is an endogenous co-agonist at the glycine site of the N-methyl-d-aspartate (NMDA) receptor.|
|S3293||Gardenoside||Gardenoside is a natural compound extracted from Gardenia fruits, with hepatoprotective properties. Gardenoside inhibits TNF-α, IL-1β, IL-6 and NFκB activation. Gardenoside also has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside suppresses the pain in rats model of chronic constriction injury by regulating the P2X3 and P2X7 receptors.|
|S3292||Falcarindiol||Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.|
|S3263||Agarotetrol||Agarotetrol is a chromone derivative found in high concentrations in the water-extract fraction of agarwood. Agarotetrol contributes to the fragrance of agarwood through the generation of LACs upon heating.|
|S3216||Uridine 5'-diphosphoglucose disodium salt||Uridine-5'-diphosphoglucose (UDPG, UDP-Glc, UDP-D-Glucose, UDP-α-D-Glucose) activates the P2Y(14) receptor, a neuroimmune system GPCR. Uridine-5'-diphosphoglucose is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms.|
|S3250||Veratrine||Veratridine (Cevadine, Cevadin, Cevadene), a steroidal alkaloid found in plants of the lily family, is a voltage-gated sodium channel activator. Veratridine induces anxiogenic-like behaviors in rats.|
|S6630||Dimethylcurcumin (ASC-J9)||Dimethylcurcumin (ASC-J9, Dimethyl curcumin, GO-Y025) is an androgen receptor (AR) degradation enhancer that suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors.|
|S2766||Glycerol||Glycerol (Glycerin) is a clear, colourless and viscous liquid that can be used as emollient, solvent or sweetening agent. Glycerol changes the separation characteristics of polyacrylamide nucleoprotein gels.|
|S8587||Withaferin A||Withaferin A (WA, WFA) potently inhibits NF-κB activation by preventing the tumor necrosis factor-induced activation of IκB kinase β via a thioalkylation-sensitive redox mechanism. Withaferin A binds to the intermediate filament (IF) protein, vimentin with antitumor and antiangiogenesis activity. Withaferin A is a steroidal lactone isolated from Withania somnifera.|
|S2653||9-amino-CPT (9-Aminocamptothecin)||9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin) is a Topoisomerase I inhibitor with potent anticancer activities. 9-amino-CPT (9-Aminocamptothecin) is an active, water-insoluble derivative of camptothecin.|
|S8620||6-Diazo-5-oxo-L-norleucine||6-Diazo-5-oxo-L-norleucine (Diazooxonorleucine, L-6-Diazo-5-oxonorleucine, DON), an antibiotic isolated from Streptomyces, is a glutaminase antagonist with IC50 of ~1 mM for cKGA (kidney-type glutaminase). 6-Diazo-5-oxo-L-norleucine exhibits analgesic, antibacterial, antiviral and anticancer properties.|
|S2654||Neoruscogenin||Neoruscogenin, a natural sapogenin isolated from R. rhizoma, is a potent and high-affinity agonist of RAR-related orphan receptor alpha (RORα or nuclear receptor NR1F1).|
|S7895||Thapsigargin||Thapsigargin is a potent, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50 of 0.353 nM or 0.448 nM for the carbachol-evoked [Ca2+]i-transients with or without a KCl-prestimulation. Thapsigargin induces cell apoptosis. Thapsigargin is extracted from a plant, Thapsia garganica.|
|S7905||3',3'-cGAMP||3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.|
|S7821||Bufalin||Bufalin (BF) is a potent inhibitor of steroid receptor coactivator SRC-3, SRC-1 and Na+/K+-ATPase. Bufalin binds to the subunit α1, α2 and α3 of Na+/K+-ATPase with Kd of 42.5 nM, 45 nM and 40 nM, respectively. Bufalin is a major digoxin-like immunoreactive component isolated from the Chinese medicine Chan Su with anti-cancer activity.|
|S7862||Rottlerin||Rottlerin (Mallotoxin, NSC 56346, NSC 94525), a natural compound purified from Mallotus Philippinensis, is a specific Protein kinase inhibitor with IC50 of 3 μM, 6 μM and 5.3 μM for PKCδ(from baculovirus-infected Sf9 insect cells), PKCδ(from porcine spleen) and CaM kinase III, respectively. Rottlerin also inhibits PKCα, PKCγ, PKCβ, PKCη, CKII and PKA with IC50 of 30 μM, 40 μM, 42 μM, 82 μM, 30 μM and 78 μM, respectively.|
|S2447||Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222)||Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM.|
|S6790||Ellipticine hydrochloride||Ellipticine Hydrochloride (NSC 71795, PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity.|
|S2288||Rubitecan||Rubitecan (9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000) is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity.|
|S2009||Indirubin-3'-monoxime||Indirubin-3'-monoxime (Indirubin-3'-oxime) is a selective CDK inhibitor with IC50 of 0.18 μM, 0.44 μM, 0.25 μM, 3.33 μM, 0.065 μM for CDK1-cyclinB, CDK2-cyclinA, CDK2-cyclinE, CDK4-cyclinD1, CDK5-p35,respectively. Indirubin-3'-monoxime is a direct and selective 5-lipoxygenase inhibitor with IC50 of 7.8-10 µM.|
|S1031||3-Hydroxybutyric acid||3-Hydroxybutyric acid (3-hydroxybutanoic acid, β-Hydroxybutyric acid, BHB) is a small molecule metabolite that is elevated in type I diabetes.|
|S2342||Phloretin (RJC 02792)||Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.|
|S9440||Naringenin chalcone||Naringenin chalcone (Chalconaringenin, Isosalipurpol, trans-2'4'6'4-tetrahydroxychalcone) is the main active component of tomato skin extract, has been proposed as an antioxidant, an anti-inflammatory, and a regulator of fat and sex hormone metabolism.|
|S6670||GPNA (L-γ-Glutamyl-p-nitroanilide)||GPNA (L-γ-Glutamyl-p-nitroanilide) is a potent and selective inhibitor of the glutamine (Gln) transporter ASCT2(SLC1A5) with Ki of 55 µM.|
|S2210||Sphingosine||Sphingosine (2-amino-4-trans-octadecene-1,3-diol, C18 Sphingosine) is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid.|
|S6674||Cytosporone B||Cytosporone B is a naturally occurring agonist for nuclear orphan receptor Nur77(NR4A1) with an EC50 of 0.278nM.|
|S6474||3,5-diiodo-L-thyronine (3,5-T2)||3,5-diiodo-L-thyronine (3,5-T2, NSC 90469) is an endogenous metabolite of thyroid hormones. 3,5-Diiodo-l-thyronine has been proposed as a potential hypolipidemic agent for treatment of obesity and hepatic steatosis.|
|S9218||Phytolaccagenin||Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phtolaccae.|
|S6653||Nigericin (NSC 292567) sodium salt||Nigericin (NSC 292567) sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.|
|S3942||Cardamonin||Cardamonin (Alpinetin chalcone), isolated from the fruits of Alpinia species, is a chalconoid with anti-inflammatory and anti-tumor activity. It has been shown to be a novel antagonist of hTRPA1 cation channel with IC50 of 454 nM while does not interact with TRPV1 nor TRPV4 channel.|
|S3867||(E)-Cardamonin||(E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.|
|S2935||Nicotinamide Riboside Chloride||Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.|
|S2425||Apocynin (NSC 2146)||Apocynin (NSC 2146, Acetovanillone, NSC 209524) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.|
|S9332||(+)-Dipentene||(+)-Dipentene, occurring commonly in nature as the fragrance of oranges, is a flavoring agent in food manufacturing.|
|S5140||Cinene||Cinene (Limonene, Dipentene) is a clear, colorless liquid hydrocarbon classified as a cyclic monoterpene, and is the major component in oil of citrus fruit peels. It is usually used to make fragrances and flavors.|
|S6019||2-Phenylphenol||2-Phenylphenol, found in lemon, is an antifungal agent and preservative used in food seasonings.|
|S5429||Diallyl sulfide||Diallyl sulfide, a thioether found naturally in garlic, is a selective inhibitor and also a substrate of CYP2E1 with an IC50 of 17.3 μM. It has protective effects against alcohol- and acetaminophen-induced hepatotoxicity in many studies.|
|S6751||Brevianamide F||Brevianamide F, belonging to a class of naturally occurring 2,5-diketopiperazines, is the simplest member and the biosynthetic precursor of a large family of biologically active prenylated tryptophan-proline 2,5-diketopiperazines that are produced by the fungi A.fumigates and Aspergillus sp..|
|S7956||Brusatol||Brusatol (NSC 172924), isolated from the fruit of B. javanica, is a NRF2 inhibitor.|
|S9513||Senkyunolide A||Senkyunolide A is one of the major bioactive ingredients in Rhizoma Chuanxiong, a Chinese medicinal herb commonly used for the treatment of cardiovascular ailments.|
|S8870||Epibrassinolide||Epibrassinolide is a brassinosteroid isolated from various plants and has been shown to decrease toxicity and stimulate healthy plant growth in plants under stress.|
|S6701||Corn Oil||Corn oil is a refined vegetable oil, and is used as delivery vehicle for fat-soluble compounds.|
|S3860||Allicin||Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects.|
|S6493||n-Butylidenephthalide||n-Butylidenephthalide ((Z)-Butylidenephthalide, 3-Butylidenephthalide, Butylidenephthalide), isolated from the chloroform extract of Angelica sinensis (AS-C), contributes to a range of biological activities, including diminution of angina, platelet aggregation, proliferation, non-specific spasmosis.|
|S3190||N6-methyladenosine (m6A)||N6-methyladenosine (m6A, NSC-29409, 6-Methyladenosine, N-Methyladenosine) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.|
|S6292||(S)-2-Hydroxysuccinic acid||(S)-2-Hydroxysuccinic acid (L-Malic acid), is a naturally occurring isomer of malic acid, found mainly in sour and unripe fruits.|
|S6061||DL-m-Tyrosine||DL-m-Tyrosine is a potent, structurally unusual broad-spectrum phytotoxin exuded by the roots of some fine leaf fescue grasses.|
|S6163||Traumatic acid||Traumatic acid (Trans-2-dodecenedioic acid) is a plant hormone that was first isolated from damaged green beans. It is a potent wound healing agent and an intermediate in prostaglandin synthesis.|
|S6112||Oxalacetic acid||Oxalacetic acid (Oxaloacetic acid, 2-Oxosuccinic acid, Ketosuccinic acid) is an intermediate of the citric acid cycle, where it reacts with acetyl-CoA to form citrate, catalysed by citrate synthase. It is also involved in gluconeogenesis, urea cycle, glyoxylate cycle, amino acid synthesis, and fatty acid synthesis. Oxaloacetate is also a potent inhibitor of Complex II.|
|S6008||p-Hydroxybenzaldehyde||p-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol), which can be found in the orchids Gastrodia elata, Galeola faberi and vanilla, is a hydroxybenzaldehyde that reacts with NAD+ and H2O to produce 4-hydroxybenzoate, NADH, and 2 protons. p-Hydroxybenzaldehyde at 101.7 μM can significantly reduce the GABA-induced chloride current of GABAA receptors(α1β2γ2S subtype) expressed.|
|S6018||2,3,4-Trihydroxybenzoic acid||2,3,4-Trihydroxybenzoic acid is a phenol constituent of Pachysandra terminalis with antioxidant activity.|
|S6043||3-Indoleacetonitrile||3-Indoleacetonitrile, a plant growth hormone, is a light-induced auxin-inhibitory substance that is isolated from light-grown cabbage (Brassica olearea L.) shoots.|
|S6045||L-Arabinitol||L-Arabinitol (L-lyxitol) is a member of the class of compounds known as sugar alcohols that exists in all living species, ranging from bacteria to humans. It can be found in a number of food items such as sweet potato, deerberry, moth bean, and European chestnut, which makes L-arabitol a potential biomarker for the consumption of these food products.|
|S6076||Phenylacetylglutamine||Phenylacetylglutamine is a product formed by the conjugation of phenylacetate and glutamine. It is a normal constituent of human urine, but other mammals such as the dog, cat, rat, monkey, sheep, and horse do not excrete this compound.|
|S9564||p-Hydroxy-cinnamic Acid||p-Hydroxy-cinnamic Acid has in vitro antimalarial activity and in vivo anti-osteoporotic properties.|
|S6303||trans-2-Hexenal||Trans-2-hexenal (Leaf aldehyde) is an α,β-unsaturated carbonyl compound protecting plants against harmful substances.|
|S9432||Ginkgolic Acid||Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT).|
|S2360||Solanesol (Nonaisoprenol)||Solanesol (Nonaisoprenol, Betulanonaprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK. It mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants.|
|S5934||(-)-Fenchone||Fenchone is a constituent of absinthe and the essential oil of fennel. It is used as a flavor in foods and in perfumery.|
|S6059||cis-3-Hexen-1-ol||cis-3-Hexen-1-ol (Leaf alcohol) is a very important aroma compound that is used in fruit and vegetable flavors and in perfumes and acts as an attractant to many predatory insects.|
|S6150||Farnesyl Acetate (mixture of isomers)||Farnesyl Acetate is a flavouring compound identified in foods such as blueberries.|
|S6162||2-Octenoic acid||2-Octenoic acid (2-Octenoate) is a normal organic acid produced by hepatic microsomal oxidation of aliphatic aldehydes and is a metabolite naturally found in the urine and plasma.|
|S6164||(-)-Citronellal||(-)-Citronellal, a constituent of citronella oil, is used in the synthesis of bioactive compounds.|
|S6208||Diethyl malonate||Diethyl malonate, naturally occuring in grapes and strawberries, is used in the synthesis of chemicals.|
|S9476||Dendrobine||Dendrobine, a plant alkaloid isolated from Dendrobium nobile, has been used for the quality control and discrimination of Dendrobium.|
|S9551||Uvaol||Uvaol is a pentacyclic triterpene, found in the non-glyceride fraction of olive pomace oil, exhibiting both pro- and anti-inflammatory properties.|
|S9481||Blinin||Blinin, isolated from the whole plant of Conyza blinii, is used in folk medicine in the south-west of China.|
|S9557||Isobergapten||Isobergapten is a furanocoumarin with plant growth regulating activity.|
|S9563||Evodine||Evodine, a natural product extracted from Evodiae fructus (EF), is a biomarker for quality assessment of EF in the Chinese Pharmacopoeia. Evodine is a potent P-gp inhibitor.|
|S9554||Bakkenolide A||Bakkenolide A (Fukinanolid), extracted from Petasites tricholobus, has been suggested to against cancer and display protective effects on inflammatory cytokines formation.|
|S9487||Praeruptorin C||Praeruptorin C is a natural compound derived from the dried roots of Peucedanum praeruptorum and has beneficial effects in suppressing osteoclast formation and resorption function. It is frequently utilized in traditional Chinese medicine for treating upper respiratory infections and as an antipyretic, antitussive, and mucolytic agent.|
|S9484||Darutoside||Darutoside, derived from botanical extracts, has a powerful regenerating action via decreasing inflammation and restoring collagen.|
|S9480||Raspberry Ketone||Raspberry ketone (p-Hydroxybenzyl acetone, Frambinone, Oxyphenylon, Rheosmin, Rasketone) is a natural phenolic compound that is the primary aroma compound of red raspberries. Raspberry ketone shows cardioprotective action against isoproterenol-induced myocardial infarction in rats, and the effects may be due to its PPAR-α agonistic activity.|
|S9473||Nuzhenide||Nuzhenide (Specnuezhenide), a major component of olive seeds, is a member of the class of compounds known as saccharolipids. It has strong antioxidant activity.|
|S9474||Acetylharpagide||Acetylharpagide is a monomeric compound extracted from Ajuga decumbens, widely used for remedying infectious and inflammatory diseases.|
|S5846||Apocarotenal||Apocarotenal is a carotenoid found in spinach and citrus fruits and plays a role as a precursor of vitamin A.|
|S9479||Complanatoside A||Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus and is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia.|
|S9488||Praeruptorin D||Praeruptorin D, a major pyranocoumarin isolated from Radix Peucedani, exhibits antitumor and anti-inflammatory activities.|
|S9491||(+)-Guaiacin||(+)-Guaiacin, found in herbs and spices, belongs to the class of organic compounds known as aryltetralin lignans.|
|S3964||Mucic Acid||Mucic Acid (Schleimsaure, Saccharolactic acid, Tetrahydroxyadipic acid, D-Glucaric acid, Galactaric acid) is the dicarboxylic sugar acid resulting from oxidation glactose with dilute nitric acid. It is a substrate of galactarate O-hydroxycinnamoyltransferase.|
|S5928||Zerumbone||Zerumbone, derived from several plant species of the Zingiberaceae family, is a naturally occurring dietary compound and may have multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities.|
|S5794||Glycochenodeoxycholic acid||Glycochenodeoxycholic acid (Glycochenodeoxycholate, Chenodeoxycholylglycine, Glycine chenodeoxycholate) is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption. Glycochenodeoxycholic acid|
|S5824||Cinnamyl alcohol||Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon. Cinnamyl alcohol can be significantly attenuated the enhanced expression of obesity-related proteins PPARγ in MDI medium-cultivated 3T3-L1 cells.|
|S5823||L-Pyroglutamic acid||L-pyroglutamic acid (L-pyroglutamate, 5-Oxoproline, pidolic acid) is a natural nutrient and amino acid derived from glutamic acid. It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase.|
|S9334||2-Pentylfuran||2-Pentylfuran (2-Amylfuran) is a naturally occuring flavouring ingredient.|
|S9033||Incensole acetate||Incensole acetate, isolated from Boswellia Resin, is a novel anti-inflammatory compound that inhibits NF-κB activation.|
|S9043||6-Shogaol||6-Shogaol, a naturally occuring product found in ginger, has anti-inflammatory and anticancer properties.|
|S9071||Nootkatone||Nootkatone, a natural ingredient that occurs in grapefruit and certain other plants, has antioxidant and anti-inflammatory effects.|
|S9094||Pogostone||Pogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity.|
|S9118||Beta-Asarone||Beta-Asarone, found in certain plants such as Acorus and Asarum, could pass the blood-brain barrier and exerts neuroprotection effects.|
|S9236||α-Cyperone||α-Cyperone (alpha-cyperone), a major active compound of Cyperus rotundus, exhibits biological activities, such as antivirulence, antigenotoxic, and antibacterial activities. α-Cyperone (alpha-cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1.|
|S5370||10-Hydroxydecanoic acid||10-Hydroxydecanoic acid, a minor constituent of royal jelly, is a saturated fatty acid that has cytotoxic effects.|
|S9450||1-Undecanol||1-Undecanol (Undecyl alcohol, 1-Hendecanol), found naturally in many foods such as fruits (including apples and bananas), butter, eggs and cooked pork, is used as a flavoring ingredient.|
|S5391||α-Boswellic acid||α-Boswellic acid is a naturally occuring triterpenoic acid.|
|S5577||6-Biopterin||6-Biopterin ( L-Biopterin, L-Erythro-Biopterin) is a natural product that has been considered as a growth factor for some insects.|
|S5743||γ-Linolenic acid||γ-Linolenic Acid (18:3, n-6), the Δ6-desaturase product of linolenic acid, is an unsaturated fatty acid found primarily in vegetable oils.|
|S5600||Flavokawain A||Flavokawain A, extracted from kava, is an apoptotic inducers and anticarcinogenic agent. Flavokawain A can down-regulation of antiapoptotic proteins, such as XIAP, survivin, and Bcl-xL, thereby changing the balance between apoptotic and antiapoptotic molecules and then induce cell death in tumor cells.|
|S9375||2'-Hydroxyacetophenone||2'-Hydroxyacetophenone is a flavouring ingredient.|
|S9379||Dihydrocoumarin||Dihydrocoumarin, a compound found in Melilotus officinalis (sweet clover) and Dipteryx odorata Willd (tonka beans), is added as a flavoring agent to a wide variety of foods, including soft drinks, yogurt, and muffins, and is used as a common fragrance in cosmetics, lotions, and soaps.|
|S9333||Gibberellins A4/A7||Gibberellins A4/A7 (Gibberellin A4 and A7) is the Gibberellin A4 Mixture With Gibberellin A7. Gibberellins A4/A7 promotes internode elongation & breaks certain dormancies in seeds. Gibberellins A4/A7 is an endogenous plant growth regulator, promotes the growth and elongation of cells.|
|S5691||Terpinyl Acetate||Terpinyl Acetate (alpha-Terpinyl), a naturally occuring compound found in several essential oils, is a flavouring agent.|
|S5684||Lapachol||Lapachol (Tecomin, CI75490, Bethabarra wood, Greenhartin), a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity.|
|S5640||Ethyl caffeate||Ethyl caffeate, a naturally occurring compound found in Bidens pilosa, suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro.|
|S9046||Berberine||Berberine (Umbellatine), an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic.|
|S9047||Leonurine Hydrochloride||Leonurine (SCM-198), a natural alkaloid extracted from Herba leonuri, is a promising anti-glycation agent with vasodilator, antioxidative, cardioprotective and neuroprotective effects.|
|S9037||Tenacissoside H||Tenacissoside H, a natural compound found in M. tenacissima, exerts anti-inflammatory and anti-tumor effects.|
|S9027||Corynoxine||Corynoxine, a natural oxindole alkaloid, is a new autophagy enhancer.|
|S9035||Isovitexin||Isovitexin (saponaretin, Apigenin-6-C-glucoside), an active component of many traditional Chinese medicines, has various activities, such as anti-oxidant, anti-inflammatory, anti-alzheimer disease (AD) effects and so on.|
|S9036||(20R)Ginsenoside Rh2||(20R)Ginsenoside Rh2, a natural compound found in Panax ginseng, shows antiviral and anticancer activities. It is a matrix metalloproteinase (MMP) inhibitor.|
|S9044||Ginsenoside F2||Ginsenoside F2, a ginsenoside found in Panax species, is an autophagic initiater with anti-cancer, and anti-obesity activities.|
|S9030||Tenacissoside I||Tenacissoside I is a natural compound found in M. tenacissima at relatively high level.|
|S9372||Ethyl palmitate||Ethyl palmitate (Ethyl hexadecanoate, Palmitic acid ethyl ester) is a long-chain fatty acid ethyl ester that is used as a hair- and skin-conditioning agent.|
|S5503||O-Acetyl-L-carnitine hydrochloride||O-Acetyl-L-carnitine (Acetyl-L-carnitine, O-acetyl-L-carnitine, O-Acetylcarnitine) can be synthesis or is naturally found in healthy humans. It could help transport fatty acids into the mitochondrial matrix where fatty acid metabolism occurs.|
|S9390||Astragaloside II||Astragaloside II, extracted from Astragalus membranaceus, has been reported to promote tissue wound repair and could be a potential adjunctive agent in cancer chemotherapy, enhancement of osteogenesis, and modulation of T cell activation.|
|S9166||Griffonilide||Griffonilide is a natural product that has been reported to induce bone remodeling activity resulting in structural changes.|
|S9169||Polygalasaponin F||Polygalasaponin F, a triterpenoid saponin isolated from Polygala japonica, possesses anxiolytic and sedative-hypnotic activities, and has cognition improving and cerebral protective effects.|
|S9220||Stylopine hydrochloride||Stylopine (Tetrahydrocoptisine, Coptisine), a major component of the leaf of Chelidonium majus L., is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.|
|S9241||Polygalaxanthone III||Polygalaxanthone III is a natural product with the efficacy of tranquilization, glaangal, eliminating sputum and detumescence. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1 with an IC50 of 50.56 μM.|
|S9259||Lithospermic acid||Lithospermic acid, an active component isolated from Salvia miltiorrhiza radix, is known to have multiple pharmacological actions such as antihypertensive and antioxidant effects.|
|S9262||Raddeanin A||Raddeanin A (Raddeanin R3, NSC382873), a triterpenoid saponin from Anemone raddeana Regel, displays moderate inhibitory activity against histone deacetylases (HDACs) and has high antiangiogenic potency, antitumor activity.|
|S9264||Decursin||Decursin (D), purified from Angelica gigas Nakai, shows potential anti-inflammatory activity and neuroprotective property.|
|S9306||Corynoxeine||Corynoxeine, which could be isolated from Uncaria rhynchophylla, is a useful and prospective compound in the prevention and treatment for vascular diseases. It is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation.|
|S9310||Isorhychophylline||Isorhynchophylline (IsoRhy, 7-Isorhyncophylline) is a major tetracyclic oxindole alkaloid isolated from the Chinese herbal medicine Uncaria rhynchophylla (Miq.)Jacks (Gouteng in Chinese). It acts as a neuronal autophagy inducer with therapeutic potential for cardiovascular and central nervous system diseases.|
|S9414||Cyasterone||Cyasterone is the main phytoecdysteroid component found in Cyathula capitata. It is a natural EGFR inhibitor and maybe a promising anti-cancer agent.|
|S9448||D-(+)-Turanose||D(+)-Turanose is a naturally occuring compound. It is a reducing disaccharide.|
|S5745||Glyceryl 1,3-dipalmitate||Glyceryl 1,3-dipalmitate acts as a metabolite of saccharomyces cerevisiae, plant and human.|
|S5686||Tryptanthrin||Tryptanthrin is a natural alkaloidal compound having basic indoloquinazoline moiety. It has broad spectrum of biological activities including anticancer activity, anti-inflammatory, antiprotozoal, antiallergic, antioxidant, and antimicrobial.|
|S5690||Triacanthine||Triacanthine, which could be isolated from the leaves of G. triacanthos, shows hypertensive activity, also cardiotonic, antispasmodic and a respiratory analeptic.|
|S5312||Urolithin A||Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.|
|S9345||Disodium 5'-Inosinate||Disodium 5'-Inosinate, widely distributed in all animal and plant tissues, is used as a flavor enhancer.|
|S9059||4'-O-Glucosylvitexin||4'-O-Glucosylvitexin is a kind of flavonoid fraction from the leaves of Crataegus pinnatifida.|
|S9364||6-Hydroxycoumarin||6-Hydroxycoumarin demonstrates cytotoxic effect against the cancer cell lines.|
|S9365||Disodium uridine-5'-monophosphate||Disodium uridine-5'-monophosphate is a nucleotide that is a major component of ribonucleic acid.|
|S9370||Adenosine Cyclophosphate||Adenosine Cyclophosphate (Cyclic adenosine monophosphate, cAMP, cyclic AMP, 3',5'-cyclic adenosine monophosphate) is useful for improving myocardial hypoxia, dilating coronary artery and strengthening myocardiac contraction.|
|S9384||Sophocarpine Monohydrate||Sophocarpine, a naturally occurring tetracyclic quinolizidine alkaloid derived from Sophora alopecuroides L, has shown promising therapeutic properties, including anti-inflammatory, anti-nociceptive, and antivirus activities.|
|S9386||Polygalacic acid||Polygalacic acid is the triterpenoid tetrahydroxyacid isolated from Polygala paenea L.. Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13 and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner.|
|S9388||(+)-Praeruptorin A||Praeruptorin A is a coumarin compound naturally occurring in the roots of Peucedanum praeruptorum Dunn., a commonly used traditional Chinese medicine for the treatment of certain respiratory diseases and hypertension. Praeruptorin A exerts anti-inflammatory effects in vitro through inhibition of NF-κB activation. (+)-Praeruptorin A is one of enantiomers.|
|S9389||Phorbol||Phorbol is a natural, plant-derived organic compound that exerts a broad range of biological activities.|
|S9401||3,6'-Disinapoyl sucrose||3,6'-Disinapoyl sucrose (Disinapoyl sucrose), an oligosaccharide ester natural product originating from the root of wild Polygala tenuifolia, has neuroprotective effects and antidepressive activity in rats.|
|S9397||Alliin||Alliin (S-allyl cysteine sulfoxide, ACSO, 3-(Allylsulphinyl)-L-alanine) is a sulfoxide that is a natural constituent of fresh garlic.|
|S9396||Geraniin||Geraniin, a hydrolysable polyphenol derived from Nephelium lappaceum L. fruit rind, has been shown to possess significant antioxidant activity in vitro.The IC50 values of TNF-α release inhibition were 43 μM for geraniin.|
|S9392||Praeruptorin B||Praeruptorin B is an important compound isolated from Bai-hua Qian-hu and has been reported to exert multiple biochemical and pharmacological activities.praeruptorin B exerts lipid-lowering effects through inhibits SREBPs and could serve as a possible therapeutic option to improve hyperlipidemia and hyperlipidemia-induced comorbidities.|
|S9404||Pristimerin||Pristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon. Pristimerin can inhibits monoacylglycerol lipase(MGL) with an IC50 of 93 nM through a reversible mechanism.|
|S9405||Sesamoside||Sesamoside, a main chemical ingredient iridoid glycoside from Lamiophlomic rotata, has analgesic and anti-inflammatory effects in animal studies.|
|S9406||Sauchinone||Sauchinone, one of the active lignan isolated from the roots of Saururus chinensis, possesses diverse pharmacological properties, such as hepatoprotective, anti-inflammatory and anti-tumor effects.|
|S9407||Angoroside C||Angoroside C, an important phenylpropanoid glycoside of the traditional Chinese medicine Scrophulariae Radix, possesses the effects of preventing ventricular remodeling, reducing pulmonary oedema, and reducing blood pressure, as well as having the properties of anti-platelet aggregation, hepatoprotection and anti-nephritis, etc.|
|S9408||Beta-Elemonic acid||Beta-Elemonic acid (3-Oxotirucallenoic Acid), a known triterpene isolated from Boswellia (Burseraceae), exhibits anti‑inflammatory effects.|
|S9409||Kavain||Kavain ((+)-Kavain), the main kavalactone found mostly in the roots of the kava plant, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. Kavain positively modulated γ-Aminobutyric acid type A (GABAA) receptor.|
|S9411||Liensinine||Liensinine, an important functional compound in lotus seeds, has anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.|
|S9412||Flavokawain B||Flavokawain B is a natural chalcone first isolated from extracts of kava roots that induces apoptosis in cancer cells.|
|S9417||Homoplantaginin||Homoplantaginin (Hispidulin-7-glucoside), a main flavonoid from a traditional Chinese medicine Salvia plebeia, has anti-inflammatory and anti-oxidant properties. Homoplantaginin inhibits TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.|
|S9422||Diosbulbin B||Diosbulbin B is the main hepatotoxic compound in Airpotato yam, which is traditionally used for treating thyroid disease and cancer.|
|S9423||Narcissoside||Narcissoside has antioxidant and antiproliferative activity in cancer.|
|S9425||Trifolirhizin||Trifolirhizin, a natural pterocarcan flavonoid extracted from Sophora flavescens, has many pharmacological activities, such as hepatoprotective, anti-inflammatory, anti-proliferation, and skin-whitening.|
|S9427||Tabersonine||Tabersonine is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus and shows hypotensive activity, anti-tumor activity, hypoglycemic, diuretic activity.|
|S9429||6α-Hydroxygeniposide||6α-Hydroxygeniposide, an iridoid glycoside, is a chemical constituents of Pittosporum glabratum Lindl.|
|S9430||Tomatidine Hydrochloride||Tomatidine Hydrochloride, a natural steroidal alkaloid, possesses potent antibacterial activity and has anti-inflammatory effects in macrophages.|
|S9431||Dehydrocorydalin||Dehydrocorydalin is an alkaloidal component isolated from Rhizoma corydalis. It has anti-inflammatory and anti-tumor effects and can protect the cardiovascular system.|
|S9433||Tubeimoside II||Tubeimoside II (Tubeimoside B), a natural triterpenoid saponin isolated from herb, show anti-inflammatory, antitumor, and antitumor-promoting effects.|
|S9434||8-Gingerol||8-Gingerol is a bioactive ingredient of ginger root (Zingiber officinale), a medicinal plant having anti-nausea, anti-inflammatory, and anti-carcinogenic properties and a carminative effect.|
|S9435||Secoxyloganin||Secoxyloganin is a secoiridoids that is extensively used in synthetic and biosynthetic studies of monoterpene indole alkaloids and related natural products.|
|S9437||Echinatin||Echinatin is a licorice extract that displays antioxidant properties and anti-inflammatory activities.|
|S9120||Scutellarein||Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities|
|S9439||Kaurenoic acid||Kaurenoic acid (kaurenoate, kaur-16-en-18-oic acid) is a natural diterpenoid found in the herbs of Croton antisyphiliticus. Kaurenoic acid has anti-inflammatory activity, the mechanisms may through inhibition of iNOS and COX-2 expression.|
|S9442||Bergaptol||Bergaptol (5-Hydroxypsoralen, 5-Hydroxyfuranocoumarin) is a natural furanocoumarin found in the essential oils of citrus including lemon and bergamot.Bergaptol is a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 μM.|
|S9443||Schisantherin B||Schisantherin B (Gomisin-B, Wuweizi ester-B) is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine.|
|S9444||Tomatine||Tomatine (Lycopersicin) is a natural glycoalkaloid with fungicidal, antimicrobial, and insecticidal properties.|
|S9447||1F-Fructofuranosylnystose||1F-Fructofuranosylnystose is a kind of Fructooligosaccharides which are naturally occurring sugars with potentially beneficial nutritional effects.|
|S9006||Perillartine||Perillartine (Perilla sugar, Peryllartine) is a sweetener. Perillartine can activation of the Tas1r2 monomeric receptors of human, rhesus monkey and squirrel monkey but not mouse in a species-dependent manner.|
|S9014||AstragalosideⅠ||AstragalosideⅠ, is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.|
|S9272||Koumine||Koumine, a Gelsemium alkaloid, possesses analgesic, anti-inflammatory and neurosteroid modulating activities.|
|S9273||Timosaponin BII||Timosaponin BII (BII, Prototimosaponin AIII) is a steroidal saponin showing potential anti-dementia and antioxidant activity.|
|S9275||Isoguanosine||Isoguanosine (Crotonoside) inhibits FLT3 and HDAC3/6 for the treatment of AML.Isoguanosine is a naturally occurring active isomer of guanosine that is found in the seeds of Croton tiglium.|
|S9276||Alisol B||Alisol B, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.|
|S9278||Saikosaponin C||Saikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities.|
|S9267||Epimedin A||Epimedin A is a major component of Herba Epimedii with bioactivities.|
|S9268||Epmedin B||Epmedin B (Epimedin B) is a component extracted from Epimedii Folium and may have antiosteoporotic activity.|
|S9269||Epmedin C||Epimedin C (Baohuoside VI), a flavonoid isolated from the herbs of Epimedium brevicornum Maxim, exhibits immunostimulatory and anticancer activities.|
|S9271||Pulchinenoside A||Pulchinenoside A (Anemoside A3), a natural triterpenoid saponin, is a AMPARs and NMDAR modulator.|
|S9284||Aloesin||Aloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro.|
|S9289||Astragalin||Astragalin (kaempferol-3-glucoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside), a flavonoid from leaves of persimmon and green tea seeds, has anti-tumor, anti-inflammatory and anti-oxidant activities.|
|S9290||Linarin||Linarin (Acaciin, Buddleoside, Acacetin-7-O-rutinoside), a natural flavonoid cpompound, has pharmacological effects, including anti-inflammatory, neuro-protective, cardioprotective and antioxidative effects.|
|S9292||Dictamnine||Dictamnine, a natural plant product, has been reported to have antimicrobial activity against bacteria and fungi.|
|S9293||Isoliquiritin||Isoliquiritin (Neoisoliquritin) is a flavonoid glycoside compound from licorice possessing a broad spectrum of pharmacological activities including antioxidant, anti-inflammatory, and anti-depression activities.|
|S9296||Fraxin||Fraxin (Fraxetin-8-O-glucoside), a main active component isolated from Cortex Fraxini, possesses a variety of bioactivities such as anti-inflammatory, antioxidant, analgesic, antimicrobial, antiviral, immunomodulatory, anti-hyperuricemia and diuresis.|
|S9297||Kirenol||Kirenol is a biologically active substance isolated from Herba Siegesbeckiae. It has been reported to possess anti-oxidant, anti-inflammatory, anti-allergic, anti-adipogenic, and anti-arthritic activities.|
|S9298||Corylin||Corylin, a main compound isolated from Psoralea corylifolia L. (Fabaceae), has a variety of pharmacological effects such as antioxidant, anti-proliferation, and anti-inflammatory properties.|
|S9301||Verbenalin||Verbenalin (Verbenalol β-D-glucopyranoside, Verbenalol glucoside, Cornin), an iridoid glycoside found in Verbena officinalis, has been reported to exhibit uterine stimulant activity and demonstrated cardioprotection against experimental myocardial ischemic injury.|
|S9302||Polyphyllin VI||Polyphyllin VI derived from Paris polyphylla possess anti-cancer activities.|
|S9303||Saikosaponin B2||Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.|
|S9304||Platycodin D||Platycodin D, the main saponin isolated from Chinese herb Platycodonis Radix, exhibits anti-inflammatory, anti-allergic, cholesterol-lowering and neuroprotective properties.|
|S9305||Toosendanin||Toosendanin, a triterpenoid extracted from Melia toosendan Sieb et Zucc, possesses broad biological actions from blocking neurotransmission and antibotulism to inducing cell differentiation and apoptosis.|
|S9308||Pulsatilla saponin D||Pulsatilla saponin D (SB365), isolated from the root of Pulsatilla koreana, targets c-Met and exerts antiangiogenic and antitumor activities.|
|S9309||Micheliolide||Micheliolide, a sesquiterpene lactone isolated from Michelia compressa and Michelia champaca, inhibits various inflammatory response and may serve as a neuroprotective agent in neuroinflammation-related neurodegenerative disorders.|
|S9312||Cyanidin-3-O-glucoside chloride||Cyanidin-3-O-glucoside chloride (Kuromanin, Chrysontemin, Glucocyanidin) is a natural product with anti-oxidant and neuroprotective effects.|
|S9313||Atractylenolide III||Atractylenolide III, a major component of Atractylodes rhizome, has anti-inflammatory and anti-angiogenesis activities.|
|S9314||Atractylenolide II||Atractylenolide II (AT-II, Asterolide, 2-Atractylenolide), a major sesquiterpenoids isolated from the dried Rhizome of Atractylodes macrocephala, shows a wide range of biological and pharmacological activities, for example, against insomnia and anxiety, neuroprotective, platelet activation and anti-cancer effect.|
|S9316||Polyphyllin II||Polyphyllin II, a natural compound extracted from Rhizoma of Paris polyphyllin, shows hemolytic activity.|
|S9317||Forsythoside A||Forsythoside A, one of the main active ingredients in Forsythiae fructus, has been shown to possess anti-bacterial and immunomodulatory properties.|
|S9318||(20R)-Ginsenoside Rh1||(20R)-Ginsenoside Rh1, isolated from the root of Panax Ginseng, exhibits various pharmacological activities including vasorelaxation, antioxidation, anti-inflammation, and anticancer.|
|S9322||Neodiosmin||Neodiosmin (Diosmetin-7-neohesperidoside, Diosmetin-7-O-neohesperidoside), a flavone glycoside isolated from C. aurantium, is a strong antioxidant with potential applications in foods, beverages, and pharmaceutical preparations.|
|S9324||Alnustone||Alnustone, a naturally occuring compound found in the rhizomes of Curcuma xanthorrhiza, exhibits anti-inflammatory, antihepatotoxic and antiemetic activities.|
|S9343||Sequoyitol||Sequoia alcohol (Sequoyitol) is isolated from Taxus natural organic compounds, it can be used to treat diabetes and other indications.|
|S9347||Allitol||Allitol (Allodulcitol) is a rare polyol found in nature that is useful not only as a sweetener, but also as the raw material for production of chemical compounds.|
|S3814||Tubeimoside I||Tubeimoside I (Lobatoside H, TBMS1), a triterpenoid saponin, isolated from the tubers of Bolbostemma paniculatum, shows potent antitumor and antitumor-promoting effects.|
|S8068||Chaetocin||Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR).|
|S9190||Oroxin B||Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.|
|S9191||Loganic acid||Loganic acid (Loganate) is a naturally occurring iridoid monoterpeneglusoside involved in the biosynthesis of indole alkaloids in Vinca rosea.|
|S9194||Toddalolactone||Toddalolactone, a natural coumarin, inhibits the activity of recombinant human Plasminogen activator inhibitor-1 (PAI-1) in a dose-dependent manner, yielding an IC50 value of 37.31 ± 3.23 μM.|
|S9195||Maltotetraose||Maltotetraose, found in many foods, belongs to the class of organic compounds known as oligosaccharides.|
|S9196||Calceolarioside B||Calceolarioside B (Nuomioside A), found in the herbs of Ajuga becumbens Thunb., has anti-proliferation property.Calceolarioside B exhibits significant inhibitory activity against rat lens aldose reductase (RLAR) with an IC50 of 23.99 μM. Calceolarioside B displays inhibitory effect on DPPH radical scavenging activity with an IC50 of 94.60 μM.|
|S9199||Pseudoginsenoside F11||Pseudoginsenoside F11, a natural product found in American ginseng but not in Asian ginseng, is a novel partial PPARγ agonist.|
|S9203||Notopterol||Notopterol is a kind of furanocoumarin that possesses anti-inflammatory, analgesic, and anticancer activities.|
|S9206||Hydroprotopine||Hydroprotopine (W1171) is a kind of natural herbal extract.|
|S9514||Rotundic acid||Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.|
|S9207||Gypenoside XVII||Gypenoside XVII (GP-17, Gynosaponin S), a ginsenoside found in Panax species, has neuroprotective effects and is widely used to prevent cardiovascular disease.GP-17 treatment predominantly up-regulating the expression of ERα but not ERβ.|
|S9208||Ginsenoside Rb3||Ginsenoside Rb3, extracted from the plant Panax ginseng, plays important roles in cardiovascular diseases, including myocardial ischemia-reperfusion (I/R) injury. Ginsenoside Rb3 (0.1-10 μM) is tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 shows the significant activity with an IC50 of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells have been treated with TNF-α (10 ng/mL).|
|S9209||Tritetradecanoin||Tritetradecanoin, found in Myristica fragrans Houtt., is used as an antiadhesion agent and lubricating agent.|
|S9210||Ginsenoside Rk1||Ginsenoside Rk1, one of the main elements of Sung Ginseng, has been confirmed as a new endothelial barrier enhancer recently and has anti-cancer activity.|
|S9211||Eriocitrin||Eriocitrin (eriodictyol 7-rutinoside, Eriodictyol glycoside, Eriodictioside) is a flavone glycoside mainly found in lemon with antioxidant activity.|
|S9213||Jujuboside A||Jujuboside A, isolated from Semen Ziziphi Spinosae, exerts anti-oxidant, anti-inflammatory activities, and reduces the cell apoptosis.|
|S9214||Jujuboside B||Jujuboside B, one of the saponins isolated from the seeds of Zizyphus jujuba var. spinosa, is used in traditional chinese medicine for treating cardiovascular diseases and neurodegenerative diseases.|
|S9215||Pinoresinol diglucoside||Pinoresinol diglucoside, one of the major lignans isolated from Eucommia ulmoides Oliver bark, has various pharmacological functions, including antihypertension and prevention of osteoporosis.|
|S9216||Esculentoside A||Esculentoside A, isolated from the Chinese herb phytolacca esculenta, possesses a broad inhibitory effect on a panel of pro-inflammation molecules with less toxicity.|
|S9217||Complanatuside||Complanatuside, a flavonoid compound isolated from Astragalus complanatus and Lysimachia christinae, has anti-inflammation, lipid-lowering and hepatoprotective effects.|
|S9219||Huperzine B||Huperzine B, a natural alkaloid existed in Lycopodium plants, is a novel acetylcholinesterase inhibitor and has neuroprotective effects.|
|S9221||Ferulaldehyde||Ferulaldehyde (Coniferaldehyde, Ferulyl aldehyde) is a natural intermediate of polyphenol metabolism of intestinal microflora.|
|S9223||Talatisamine||Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is a newly identified K+ channel blocker with hypotensive and antiarrhythmic activities.|
|S9226||Steviolbioside||Steviolbioside (CCRIS-6025), a natural sweetener, exhibits moderate antituberculosis activity against M. tuberculosis strain H37RV in vitro.|
|S9228||Schisandrin C||Schisandrin C, a dibenzocyclooctadiene lignan isolated from the fruits of Schisandra chinensis (Turcz.) Baill, has many characteristics including anti-inflammation, anti-tumor, and anti-oxidation.|
|S9229||Linderane||Linderane, isolated from Lindera strychnifolia vill., is an indirect PDE3 activator and possesses multiple biological effects, including superoxide anion radical-scavenging and antioxidative activity and protective activity against gastritis, gastric ulcers and backache.|
|S9230||Vaccarin||Vaccarin, a major flavonoid glycoside found in Semen vaccariae, exhibits extensive biological activities including vascular endothelial cell protective effects.|
|S9231||Schisanhenol||Schisanhenol (Gomisin K3) is a compound derived from the fruit of a traditional Chinese herb Schisandra rubriflora, exhibiting strong inhibition toward UGT2B7.|
|S9232||Crocin II||Crocin II (Crocin B, Crocetin gentiobiosylglucosyl ester, Tricrocin), a carotenoid chemical compound that is found in the flowers crocus and gardenia, is an antioxidant and neural protective agent.|
|S9233||Imperialine||Imperialine (Sipeimine, Kashmirine) is an alkaloid found in the bulbs of species of the genus Fritillaria.|
|S9234||Schaftoside||Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.|
|S9237||Berberrubine||Berberrubine (Beroline, 9-Berberoline), an isoquinoline alkaloid isolated from many medicinal plants, possesses diverse pharmacological activities, including glucose-lowering, lipid-lowering, anti-inflammatory, and anti-tumor effects.|
|S9238||Polygalic acid||Polygalic acid (Senegenic acid), a triterpenoid saponin, shows expectorant, emetic and stimulant effects.|
|S9239||Isocorynoxeine||Isocorynoxeine (7-Isocorynoxeine), a major alkaloid found in Uncaria rhynchophylla, exhibits wide beneficial effects on the cardiovascular and cardiocerebral vascular systems. Isocorynoxeine suppress 5-HT2A receptor-mediated current response with IC50 of 72.4 μM.|
|S9242||Narirutin||Narirutin (Naringenin-7-O-rutinoside, Isonaringin), a flavanone abundant in citrus fruits, possesses anti-inflammatory and anti-oxidative effects.|
|S9243||Protosappanin B||Protosappanin B (FT-0689654, Q-100961), extracted from Lignum Sappan, possesses anti-inflammation and anti-oxidation properties.|
|S9246||Tiliroside||Tiliroside, a glycosidic flavonoid, possesses anti-inflammatory, antioxidant, anticarcinogenic and hepatoprotective activities.|
|S9247||Isoliensinine||Isoliensinine is an alkaloid produced by the edible plant Nelumbo nucifera. It possesses anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.|
|S9250||Isosilybin||Isosilybin (Silymarin, Silybin B, Isosilybinin, Q-100795) is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. Isosilybin inhibits CYP3A4 induction with an IC50 of 74 μM.|
|S9251||Oxypeucedanin||Oxypeucedanin is a major coumarin aglycone that can be extracted from Ostericum koreanum. It is a kind of open-channel blocker of the hKv1.5 channel.|
|S9252||Corydaline||Corydaline is a bioactive alkaloid with various anti-acetylcholinesterase, anti-allergic, and anti-nociceptive activities found in the medicinal herb Corydalis Tubers.|
|S9254||Skimmin||Skimmin is one of the major pharmacologically active molecules present in Hydrangea paniculata, a medical herb used in the traditional Chinese medicine as an anti-inflammatory agent.|
|S9256||Isobavachin||Isobavachin is a flavonoid compound obtained from Psoralea Corylifolia Linn.|
|S9257||Acetylshikonin||Acetylshikonin is a biologically active compound with anti-cancer and anti-inflammatory activity, which is isolated from the roots of Lithospermum erythrorhizoma. It is a novel general P450 inhibitor with IC50 values of 1.4-4.0 μM for all tested P450s.|
|S9258||(+)-Isocorynoline||Isocorynoxeine, a major bioactive tetracyclic oxindole alkaloids found in Uncaria rhynchophylla, exhibits a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM and shows various beneficial effects, including lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage.|
|S9260||Nodakenin||Nodakenin ((+)-Marmesinin), a coumarin compound, acts as an AChE inhibitor that inhibits AChE activity in a dosedependent manner with an IC50 value of 84.7 μM.|
|S9266||Ginsenoside Rc||Ginsenoside Rc, isolated from Panax ginseng, may exert various activities including anti-cancer, anti-inflammatory, antiobesity, and anti-diabetic effects.|
|S9186||Liensinine perchlorate||Liensinine is the active constituent of plumula nelambinis with anti-hypertension.|
|S9187||Phillygenin||Phillygenin (Sylvatesmin), a bioactive intergradient in Osmanthus fragrans, has anti-inflammatory, anti-obesity and antipyretic activities. It could reduce blood lipid levels and low density lipoprotein.|
|S9517||Liriope muscari baily saponins C||Liriope muscari baily saponins C, extracted from the roots of Liriope muscari (Decne.) Baily, induces autophagy and has an anti-thrombotic activity.|
|S9201||Levistilide A||Levistilide A (Diligustilide), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.|
|S9512||1,3-Dicaffeoylquinic acid||1,3-Dicaffeoylquinic acid (Cynarin; Cinarine; 1,5-Dicaffeoylquinic acid) is a phenolic compound found in artichoke. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.|
|S9114||Polyphyllin I||Polyphyllin I, a small molecular monomer extracted from Rhizoma of Paris polyphyllin, is used in the treatment of infectious disease and cancer. Polyphyllin I inhibits proliferation and induces apoptotic cell death in U251 cells. Polyphyllin I is an activator of the JNK signaling pathway with a potential anti-glioma effect.|
|S9115||Wogonoside||Wogonoside (Oroxindin, Wogonin 7-O-glucuronide, Glychionide B), the main flavonoid component derived from the root of Scutellaria baicalensis Georgi, displays anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities.|
|S9116||Chikusetsusaponin IVa||Chikusetsusaponin IVa (Calenduloside F), a major active ingredient of triterpenoid saponins, has numerous pharmacological activities, including cytotoxic activity against various cancer cells, anti-inflammatory activity, prevention of dental caries and induction of genta-micin nephrotoxicity. Chikusetsusaponin IVa is a novel AMPK activator.|
|S9117||(20S)Ginsenoside Rg2||(20S)Ginsenoside Rg2, a constituent existing in red ginseng, has been reported to exert strong inhibitory action on various cancer cells.|
|S9119||Leonuride||Leonuride (Ajugol), an active alkaloid that is extracted from Traditional Chinese Medicine Herba leonuri, is a terpene glycoside that can be used for some gynecological disease.|
|S9121||Irigenin||Irigenin, an O-methylated isoflavone, can be isolated from the rhizomes of the leopard lily (Belamcanda chinensis), and Iris kemaonensis.|
|S9122||Tectorigenin||Tectorigenin (TEC) is an isoflavone isolated from various medicinal plants, such as Pueraria thunbergiana Benth, Belamcanda chinensis, and Iris unguicularis. It has been reported to exert pharmacological actions, including antitumor and antibacterial effects, free radical neutralization, and selective estrogen receptor modulation.|
|S9125||Apigetrin||Apigetrin (Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside), a flavonoid found in many plant leaves and seeds, has been known to possess antimutagenic, anti-cancer, antioxidant and anti-inflammatory properties.|
|S9126||Schizandrol B||Schizandrol B (Gomisin A, Besigomsin, Wuweizi alcohol B, Gamma-Schisandrin), extracted from the fruit of Schisandra chinensis Baill., exhibits potent antitumor activities.|
|S9127||Carnosol||Carnosol is a naturally occurring phenolic diterpene found in rosemary. It has anti-oxidant, anti-inflammatory and anti-cancer activities.|
|S9128||Isoacteoside||Isoacteoside, a phenylethanoid isolated from Monochasma savatieri Franch. ex Maxim., is an anti‐inflammatory herb widely used in traditional Chinese medicine.|
|S9129||20(S)-Ginsenoside Rh1||20(S)-Ginsenoside Rh1 (Prosapogenin A2, Sanchinoside B2, Sanchinoside Rh1) is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. It exhibits potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system. Ginsenoside Rh1 inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.|
|S9130||Rubusoside||Rubusoside is a natural sweetener and a solubilizing agent with antiangiogenic and antiallergic properties.|
|S9131||Punicalagin||Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects.|
|S9132||Harpagide||Harpagide, isolated from the secondary roots of Harpagophytum procumbens (Hp), has valuable medicinal properties, such as anti-inflammatory, analgesic and potential antirheumatic effects.|
|S9135||Artemisic acid||Artemisic acid (Artemisinic acid), an amorphane sesquiterpene isolated from Artemisia annua L., has a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect.|
|S9137||Erianin||Erianin, a natural product derived from Dendrobium chrysotoxum, has been used as an analgesic in traditional Chinese medicine and is a potential anti-tumor agent. Erianin can inhibit IDO-induced tumor angiogenesis.|
|S9138||Picfeltarraenin IA||Picfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system.|
|S9144||Solasonine||Solasonine, a natural glycoalkaloid compound, has anti-inflammation and anti-tumor properties.|
|S9145||Solamargine||Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.|
|S9146||Anwuligan||Anwuligan (Macelignan), a natural compound isolated from Myristica fragrans Houtt, has antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. It also shows antioxidant, free radical scavenging, and neuroprotective activities.|
|S9148||Peiminine||Peiminine (Verticinone, Zhebeinone, Raddeanine), a biologically active component extracted from Fritillaria walujewii Regel, has been reported to have potent anti-inflammatory, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth.|
|S9149||Benzoylpaeoniflorin||Benzoylpaeoniflorin, a natural product isolated from Chinese paeony root, could inhibit COX-1 and COX-2 in vitro.|
|S9150||Daurisoline||Daurisoline, a bis-benzylisoquinoline alkaloid isolated from the rhizomes of Menispermum dauricum, is a potent autophagy blockers with antiarrhythmic effects.|
|S9152||Epiberberine||Epiberberine, a natural protoberberine alkaloid, is a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean).|
|S9153||Betulinicaldehyde||Betulinicaldehyde (Betulinal, Betunal), isolated from the bark of tectona grandis., is an anti-tumor agent.|
|S9155||Aurantio-obtusin||Aurantio-obtusin is a natural effective compound isolated from Semen Cassiae, which possesses hypotensive and hypolipidemic effects.|
|S9157||Neoandrographolide||Neoandrographolide, a principle diterpenoids isolated from A. paniculata, exerts a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, anti-viral, anti-bacterial, anti-diabetic, anti-oxidative stress, antipyretic, anti-edematogenic, and anti-nociceptive activities.|
|S9159||momordin-Ic||Momordin Ic, a natural triterpenoid saponin, is a novel SENP1 (SUMO-specific protease 1) inhibitor that inhibited proliferation of prostate cancer cells in vitro and in vivo.|
|S9160||Ziyu-glycoside I||Ziyuglycoside I is one of the major active ingredients in Sanguisorba officinalis and could be used as an active ingredient for cosmetics.|
|S9161||Ziyuglycoside II||Ziyuglycoside II is an active compound of Sanguisorba officinalis L. that has anti-inflammation, antioxidation, antibiosis, and homeostasis properties.|
|S9162||Rubimaillin||Rubimaillin (Mollugin), found in the Chinese medical plant Rubia cordifola, is a dual inhibitor of acetyl-CoA cholesterol acyltransferase 1 (ACAT1) and acetyl-CoA cholesterol acyltransferase 2 (ACAT2), but is more selective for the ACAT2 isozyme.|
|S9163||Rhapontigenin||Rhapontigenin (Protigenin), produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation, is a selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM).|
|S9164||Curdione||Curdione, one of the major components of Curcuma zedoaria, shows an excellent antithrombotic activity in vivo.|
|S9165||Poncirin||Poncirin (Isosakuranetin-7-neohesperidoside), extracted from trifoliate orange, has anti-bacterial and anti-inflammatory activities.|
|S9173||Sec-O-Glucosylhamaudol||Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) is one of the major bioactive compounds of the Saposhnikoviae Radix.|
|S9174||Xanthotoxol||Xanthotoxol (8-Hydroxypsoralen, 8-Hydroxypsoralene, 8-Hydroxyfuranocoumarin, Psoralen), a biologically active linear furocoumarin found in a large number of plants, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects.|
|S9175||Macranthoidin A||Macranthoidin A, found in the herbs of Lonicera japonica Thunb., has anti-inflammation activity.|
|S9176||Pimpinellin||Pimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity.|
|S9177||Gypenoside XLIX||Gypenoside XLIX, a naturally occurring gynosaponin, is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator.|
|S9180||Tussilagone||Tussilagone, isolated from the flower of buds of Tussilago farfara (Compositae), is a sesquiterpenoid that is used as a traditional oriental medicine for asthma and bronchitis. It shows anti-inflammatory activity in in vitro studies.|
|S9181||Periplocin||Periplocin (Periplocoside), extracted from the traditional herbal medicine cortex periplocae, has cardiac and anticancer activity. Periplocin could significantly boost proliferation, migration and stimulate collagen production in fibroblast L929 cells, which is dependent on activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase, and thus promoting wound healing.|
|S9182||Crebanine||Crebanine, an aporphine alkaloid isolated from the crude hexane extract of the dried tuber of Stephania venosa, exhibits anti-cancer effects.|
|S9184||Forsythoside B||Forsythoside B is a phenylethanoid glycoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant. Forsythoside B has potent neuroprotective effects and has anti-inflammation, antioxidant, and antisepsis properties. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.|
|S9185||Nitidine Chloride||Nitidine Chloride, a benzophenanthridine alkaloid found in species of the genus Zanthoxylum, has an anti-malarial activity.|
|S9515||Polyphyllin VII||Polyphyllin VII (Y-0166), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas, including lung cancer, breast cancer, colorectal cancer, cervical cancer, hepatocellular carcinoma and osteosarcoma.|
|S9055||Salvianolic acid A||Salvianolic acid A (Dan Phenolic Acid A), a water-soluble compound extracted from Radix Salvia miltiorrhiza (Danshen), is an antioxidant and free radical scavenging compound that also acts as an inhibitor of the protein-protein interaction mediated by SH2 domains of Src-family kinases Src and Lck.|
|S9052||Auraptene||Auraptene (7-geranyloxycoumarin) is a natural coumarin derived from citrus plants and possesses valuable pharmacological properties, including anticarcinogenic, anti-inflammatory, antihelicobacter, antigenotoxic, and neuroprotective effects. Auraptene inhibits matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8 and chemokine (C-C motif) ligand-5(CCL5).|
|S9045||Triptophenolide||Triptophenolide (Hypolide), derived from Tripterygium wilfordii, is a pan-antagonist for wild-type and mutant androgen receptors with the IC50 values of 260 nM for AR-WT, 480 nM for AR-F876L, 388 nM for AR-T877A, and 437 nM for W741C+T877A.|
|S9061||Hydroxy safflor yellow A||Hydroxy safflor yellow A, a monomer extracted from Carthamus tinctorius L., possesses various kinds of bio-activities, including anti-oxidation, anti-inflammatory actions, anti-platelet aggregation, anti-tumor and anti-myocardial injury effects.|
|S9062||4-Hydroxyisoleucine||4-Hydroxyisoleucine, an atypical branched-chain amino acid derived from fenugreek, has effects on the glucose and lipid metabolism, stimulates glucose-dependent insulin secretion and reduces insulin resistance in muscle and/or liver.|
|S9064||Trilobatin||Trilobatin (P-Phlorizin), a natural flavonoid lipid molecule, is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and exihibits anti-oxidant and anti-inflammatory effect.|
|S9065||Songorine||Songorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties.|
|S9066||Specnuezhenide||Specnuezhenide (Nuezhenide), one of the main ingredients of Chinese medicine, has anti-angiogenic and vision improvement effects.|
|S9067||Pseudoprotodioscin||Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.|
|S9069||Jatrorrhizine chloride||Jatrorrhizine chloride (Neprotine, Yatrorhizine) is the hydrochloride salt form of jatrorrhizine, which is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.|
|S9070||Isoxanthohumol||Isoxanthohumol is one of the most important prenylflavonoids found in hops. It exhibits an antiproliferative activity against human breast cancer cell lines, ovarian cancer, prostate cancer, and colon cancer cells. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV).|
|S9072||Sweroside||Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects.|
|S9073||Lithospermoside||Lithospermoside (Griffonin), extracted from the roots of Lithospermum purpurocaeruleum and L.officinale (Borginaceae), and Thalictrum rugosum and T. dasycarpum (Ranunculaceae), has anti-oxidant, anti-tumor promoting activities.|
|S9074||Buddlejasaponin IVb||Buddlejasaponin IVb (Saikosaponin 1b), a major component of Pleurospermum kamtschaticum, exerts anti-inflammatory and cytotoxic effects against cancer cells.|
|S9075||Mulberroside A||Mulberroside A, isolated from the ethanol extract of Morus alba roots, is widely employed as an active ingredient in cosmetic products due to its anti-tyrosinase and anti-oxidant activities. Mulberroside A decreases the expressions of TNF-α, IL-1β and IL-6 and inhibits the activation of NALP3, caspase-1 and NF-κB and the phosphorylation of ERK, JNK and p38.|
|S9076||Typhaneoside||Typhaneoside is a flavonoid glycoside plant extract that has an inhibitory effect on the proliferation of human umbilical arterial smooth muscle cell(HUASMC).|
|S9077||Plantamajoside||Plantamajoside (Y0160, C10485), a hydroxycinnamic acid, is used as a biomarker in chemotaxonomical studies, and is a compound with numerous biological applications and considerable pharmacological potential.|
|S9078||Epigoitrin||Epigoitrin (Goitrin, BA-51-090278), the main bioactive constituent of Radix isatidis, exerts antiviral, anticancer, and antithyroid activities.|
|S9079||Ginsenoside Rb2||Ginsenoside Rb2 (Ginsenoside C) is a ginsenoside found in Panax ginseng that has a role as a plant metabolite, an antiviral agent and a hypoglycemic agent.|
|S9081||Anemoside B4||Anemoside B4 (Pulchinenoside B4, Chinensioside A, Pulchinenoside C, Pulsatilla saponin B4), extracted from the herb of Pulsatilla chinensis (Bge.) Regel, is a potential antiviral constituent and inhibits the secretion of IL-10.|
|S9082||Manninotriose||Manninotriose, found in many foods, is a novel and important player in the RFO metabolism of red dead deadnettle.|
|S9083||Rhapontin||Rhapontin (Ponticin, Rhaponticin, Rhapontigenin glucoside), a stibene-type glycoside distributed widely in medicinal plants of Rheum genus (Polygonaceae), has anti-inflammatory effect and anti-proliferative activity.|
|S9084||Rhoifolin||Rhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects.|
|S9085||Corynoline||Corynoline is one of the major active components of many ethnopharmacological plants and exhibits anti-tumor, anti-inflammatory and hepatoprotective activities, etc.|
|S9112||Kaempferitrin||Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.|
|S9113||Ononin||Ononin (Formononetin glucoside, Formononetin 7-O-glucoside) is an isoflavone glycoside with anti-inflammtory effects.|
|S9020||Dihydrotanshinone I||Dihydrotanshinone I (15,16-dihydrotanshinone I) is a naturally occurring compound extracted from Salvia miltiorrhiza Bunge, also known as Chinese sage, red sage root, and the Chinese herbal Dan Shen. It is a potent inhibitor of the HuR:RNA interaction, active in the low nanomolar range, mainly by limiting the association rate of HuR with RNA.|
|S9021||(20R)Ginsenoside Rg3||(20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite.|
|S9022||20S-Ginsenoside Rg3||20S-Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It exihits neuromodulatory, cognition enhancing, anti-inflammatory, antioxidative, anti-angiogenic, and anticancer activities.|
|S9023||20S-Ginsenoside Rh2||20S-Ginsenoside Rh2 is a ginsenoside found in Panax species and inhibits cancer development, progression, and metastasis.|
|S9026||Hastatoside||Hastatoside is a characteristic constituent of V. officinalis and exhibit various biological activities including sleep-promoting, antioxidant and hepatoprotective activity.|
|S9029||Prim-o-glucosylcimifugin||Prim-O-glucosylcimifugin (Cimifugin beta-D-glucopyranoside, Cimifugin 7-glucoside) is a major constituent in Radix Saposhnikovia that has been long used for the treatment of pyrexia, rheumatism, and cancer in traditional Chinese medicine. It shows potential anticancer activity. Prim-O-glucosylcimifugin downregulates the mRNA and protein expression inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) in LPS-activated RAW 264.7 macrophages in a concentration-dependent manner.|
|S9039||Albiflorin||Albiflorin, a natural product isolated from Paeoniae Radix, is a novel 5-HT and NE reuptake inhibitor with high selectivity.|
|S9040||Maslinic acid||Maslinic Acid (Crategolic Acid, 2α-Hydroxyoleanoic Acid), a Natural Triterpene, exerts a wide range of biological activities, i.e. antitumor, antidiabetic, antioxidant, cardioprotective, neuroprotective, antiparasitic and growth-stimulating. MA significantly suppresses the DNA-binding activity of NF-κB p65 in LPS-induced RAW 264.7 cells.|
|S9054||Pectolinarin||Pectolinarin is a major compound in Cirsium setidens with anti-inflammatory activity. Pectolinarin inhibits secretion of IL-6 and IL-8, as well as the production of PGE2 and NO. Pectolinarin induces apoptosis via inactivation of the PI3K/Akt pathway.|
|S9049||Parishin A||Parishin A, isolated from the rhizomes of Gastrodia elata, has good neuroprotective effects against brain disorders.|
|S9060||Nystose||Nystose (1,1-Kestotetraose, Fungitetraose), a constituent of seeds of onions and roots of Asparagus, is a low-calorie sweetening agent for food and chewing gum.|
|S9092||Norisoboldine||Norisoboldine (Laurelliptine), a natural aryl hydrocarbon receptor (AhR) agonist, attenuates ulcerative colitis (UC) and induces the generation of Treg cells.|
|S9093||Nardosinone||Nardosinone, isolated from Nardostachys root, an important Chinese herbal medicine, is an enhancer of nerve growth factor and possesses a wide range of pharmacological effects, including sedative, adaptogen-like, anti-depressive, anti-leukemic, anti-tumorous, and anti-trypanosomal activities.|
|S9097||Alisol B Acetate||Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.|
|S9099||Orientin||Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects.|
|S9100||Fraxinellone||Fraxinellone is a natural product isolated from the D. dasycarpus plant, which has been shown to exhibit neuroprotective and anti-inflammatory activities.|
|S9103||Ginsenoside Ro||Ginsenoside Ro (Chikusetsusaponin V), one of the high-abundance saponins in ginseng, is widely used as a dietary supplement and has many health-promoting effects.|
|S9104||Maltopentaose||Maltopentaose is a substrate for energy metabolism and carbon for E. coli.|
|S9105||Ginsenoside CK||Ginsenoside CK is a ginsenoside found in Panax species and has a role as a plant metabolite, an antineoplastic agent, a hepatoprotective agent, an anti-allergic agent and an anti-inflammatory agent.|
|S9108||Timosaponin A3||Timosaponin A3 (Filiferin B, AneMarsaponin A3), one of the major steroidal saponin components isolated from Anemarrhena asphodeloides, displays promising pharmacological activity in improving learning, memory, and antineoplastic activity.|
|S9056||Tuberostemonine||Tuberostemonine, a natural product found in Stemona phyllantha and Stemona tuberosa, is an alkaloid and a metabolite.|
|S9051||Asperuloside||Asperuloside, an iridoid glycoside found in Herba Paederiae, is a component from traditional Chinese herbal medicine and exerts anti-inflammatory effect.|
|S9048||(+)-Gallocatechin||(+)-Gallocatechin, found notably in green tea, has moderate affinity to the human cannabinoid receptor and acts as an antioxidant.|
|S9057||Sinigrin||Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects.|
|S9058||Gallocatechin gallate||Gallocatechin galleate (GCG) is a polyphenol originally derived from a variety of sources, including green tea, coffee, safflower, and almonds.|
|S9088||Calycosin-7-O-beta-D-glucoside||Calycosin-7-O-beta-D-glucoside, an isoflavone glycoside isolated from A. mongholicus and A. membranaceus, has antioxidant, anti-inflammatory, and neuroprotective biological activities.|
|S9090||Corilagin||Corilagin, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others. It is an inhibitor of TNF-α.|
|S9091||10-Gingerol||10-Gingerol is a bioactive compound found in ginger with anti-inflammatory and antioxidant activity.|
|S9095||Senegenin||Senegenin (Tenuigenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and antiinflammatory activity.|
|S9096||ligustroflavone||Ligustroflavone (Nuezhenoside), isolated from the leaves of Turpinia montana, shows high antioxidant capacity and is reported to be an AMPK activator.|
|S9106||Eleutheroside E||Eleutheroside E, a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory effects by inhibiting NF-κB and protecting against myocardial infarction.|
|S9107||Glycitein||Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.|
|S9109||1-Kestose||1-Kestose (1F-beta-D-Fructosylsucrose), a fructooligosaccharide, could efficiently stimulates Faecalibacterium prausnitzii as well as Bifidobacteria in humans.|
|S3774||Dehydroandrographolide Succinate Potasium Salt||Dehydroandrographolide Succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.|
|S9008||20-Deoxyingenol||20-Deoxyingenol is a natural compound isolated from the seeds of Euphorbia lathyris L.|
|S5145||Protoporphyrin IX||Protoporphyrin IX (PPIX) is a heterocyclic organic compound, which consists of four pyrrole rings, and is the final intermediate in the heme biosynthetic pathway.|
|S5373||Pseudolaric Acid B||Pseudolaric Acid B, a natural diterpenoid compound isolated from the root and trunk bark of Pseudolaric kaempferi Gordon, has anti-fungal and anti-fertility properties.|
|S5678||trans-Zeatin-riboside||Zeatin Riboside is the most active and ubiquitous form of the naturally occurring cytokinins that promote cell division, stimulate shoot proliferation, inhibit root formation, slow the aging process, and activate gene expression and metabolic activity. Zeatin riboside has an immunomodulatory effect by agonizing the mammalian adenosine A2A receptor.|
|S5622||Prohydrojasmon||Prohydrojasmon is a newly launched plant growth regulator, which has jasmonic acid activity.|
|S3993||Ethyl Vanillate||Ethyl vanillin (Bourbonal, Ethylprotal), a vanillin analog, is a flavouring agent and a fungicidal agent that exhibits strong antioxidant activity. Ethyl Vanillate inhibits 17β-HSD2 with an IC50 1.3 µM.|
|S5161||1-Octacosanol||1-Octacosanol (n-Octacosanol, Octacosyl alcohol, Octanosol, Montanyl alcohol, Cluytyl alcohol) is a straight-chain aliphatic 28-carbon primary fatty alcohol that is used as a nutritional supplement. It is reported to possess cholesterol-lowering effects, antiaggregatory properties, cytoprotective use, and ergogenic properties.|
|S5172||1-Triacontanol||1-Triacontanol (n-Triacontanol, Melissyl alcohol, Myricyl alcohol) is a fatty alcohol found in plant cuticle waxes and in beeswax. It is a growth stimulant for many plants, most notably roses.|
|S5142||D-(+)-Melezitose||Melezitose (D-Melezitose, (+)-Melezitose, D-melicitose, (+)-melicitose, melicitose) is a nonreducing trisaccharide sugar that is produced by many plant sap eating insects.|
|S5128||Orsellinic acid ethyl ester||Orsellinic acid (Ethyl Orsellinate), a phenolic acid, is of importance in the biochemistry of lichens, from which it can be extracted.|
|S4863||4-Hydroxyphenylacetic acid||4-Hydroxyphenylacetic acid (p-Hydroxyphenylacetic acid, parahydroxy phenylacetate), a chemical compound found in olive oil and beer, is an intermediate used to synthesize atenolol and 3,4-dihydroxyphenylacetic acid. 4-hydroxyphenylacetic acid is an inducer of Nrf2 expression.|
|S4864||2-Furoic acid||2-Furoic acid (2-Furancarboxylic acid, Pyromucic acid, 2-Carboxyfuran, α-furancarboxylic acid, α-furoic acid) is an organic compound most widely found in food products as a preservative and a flavoring agent.|
|S4960||Jasmone||Jasmone is a natural organic compound extracted from the volatile portion of the oil from jasmine flowers.|
|S4941||Farnesol||Farnesol is a natural sesquiterpene alcohol that is potent in treating antimetabolic disorders, anti-inflammation, showing antioxidant, anticancer, and antibiotic effects.|
|S5122||Abietic Acid||Abietic acid (Sylvic acid, Abietate, Rosin Acid), an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.|
|S5135||Hydroferulic acid||Hydroferulic acid (Dihydroferulic acid, Dihydroconiferylic acid) is classified as a member of the phenylpropanoic acids. It is slightly soluble in water and acidic.|
|S4963||Purpurin||Purpurin (1,2,4-Trihydroxyanthraquinone, Hydroxylizaric acid, Verantin) is one of the natural colorants extracted from madder roots and other Rubiaceae family plants. It exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative activities. Purpurin strongly inhibits the activities of CYP1A1, CYP1A2 and CYP1B1.|
|S4968||Cholesteryl Acetate||Cholesteryl Acetate (Acebrochol, Cholesterol, Cholesterin), present in diverse fluids, organs, and foods, is a natural and normal human cholesteryl ester.|
|S5175||(-)-Ambroxide||Ambroxide, a naturally occurring terpenoid, is one of the key constituents responsible for the odor of ambergris and an autoxidation product of ambrein.|
|S4762||2,4-Dihydroxyacetophenone||2,4-Dihydroxyacetophenone (Resacetophenone, 4-Acetylresorcinol) is a plant metabolite that can act as a qualitative reagent for ferric iron.|
|S4765||Syringaldehyde||Syringaldehyde (Syringic aldehyde) is an organic compound that occurs naturally in trace amounts. It possesses worthy bioactive properties and is, therefore, used in pharmaceuticals, food, cosmetics, textiles, pulp and paper industries, and even in biological control applications. Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL. Anti-hyperglycemic and anti-inflammatory activities.|
|S5110||Safflower Yellow||Safflower Yellow (Safflor Yellow, SY), the main active constituent of the traditional Chinese medicine Safflower, is known as a neuroprotective agent that indirectly attenuates neuroinflammation.|
|S5116||Bilibubin||Bilibubin (Bilirubin) is a tetrapyrrole and a breakdown product of heme catabolism that acts as a physiological, chain-breaking antioxidant.|
|S4772||alpha-Asarone||Alpha (α)-asarone (trans-Asarone) is one of the main pharmacologically active compounds present in Acorus calamus Linn (Acoraceae), Acorus tatarinowii Schott (Acoraceae), and Acorus gramineus Solander. It has anticonvulsant, neuroprotective, anxiolytic and nootropic effects.|
|S4774||Xanthurenic Acid||Xanthurenic acid (xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3).|
|S3896||(1R,2R)-trans-N-Boc-1,2-cyclohexanediamine||(1R,2R)-trans-N-Boc-1,2-cyclohexanediamine is an intermediate in organic synthesis.|
|S3900||Betulonic acid||Betulonic acid (Liquidambaric acid), derived from betulinol, a pentacyclic styrene, has shown a highly specific anti-prostate cancer activity in in vitro cell cultures.|
|S4784||Phloracetophenone||Phloracetophenone, or 2,4,6-trihydroxyacetophenone (THA), the aglycone component of phloracetophenone glucoside, is a naturally occurring compound obtained from the rhizome of Curcuma comosa (Family Zingiberaceae). Phloracetophenone can stimulate CYP7A1 activity. Phloracetophenone induces cholestasis in rats mediated through Mrp2.|
|S3904||Isoimperatorin||Isoimperatorin, a natural furanocoumarin that can be isolated from a variety of plant parts, has analgesic, antimicrobial, vascular relaxing and anticancer activities. Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC50 of 74.6 μM.|
|S4788||L-α-Phosphatidylcholine||L-α-phosphatidylcholine, a surfactant and a constituent of the liposomal carrier system, has shown hepatoprotection in the various hepatotoxicity model.|
|S4791||S-allyl-L-cysteine||S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. S-Allyl cysteine has an anticancer effect through the induction of apoptosis and a cell cycle arrest.|
|S4793||Cedryl acetate||Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity.|
|S4809||3-Indolepropionic acid||3-Indolepropionic acid (IPA, indole-3-propionic acid), a gut microbial metabolite, is a potent neuroprotective antioxidant and plant auxin.|
|S5124||DL-Citrulline||L-Citrulline (Citrulline, Cit) is a naturally occurring nonessential amino acid which is the key intermediate in the urea cycle.|
|S3989||L-Histidine||L-Histidine (Glyoxaline-5-alanine) is an α-amino acid needed in humans for growth and tissue repair. It is used in the biosynthesis of proteins.|
|S3990||Trans-Anethole||Trans-anethole (4-Propenylanisole) is a phenylpropene derivative found in many essential oils, including anise oil. It has neuromodulatory, anxiolytic, antioxidative, antifungal, anti-inflammatory, and immunomodulatory activities.|
|S4981||Cyclogalegenol||Cyclogalegenol (Astramembrangenin, Cyclosieversigenin), the aglycone derivative of astragaloside A, is found in various species of Astragalus and may activate telomerase.|
|S4982||2,2':5',2''-Terthiophene||2,2':5',2''-Terthiophene is a natural product occurring in marigold which shows UV-enhanced antibiotic activity.|
|S5090||4-Isopropylbenzyl Alcohol||4-Isopropylbenzyl Alcohol (Cumic alcohol, Cuminyl alcohol, Cuminic alcohol), isolated from Eucalyptus camaldulensis, is a compound with insect repellent properties.|
|S5089||4-Isopropylbenzaldehyde||4-Isopropylbenzaldehyde (Cuminaldehyde, Cuminic aldehyde, Cuminal), a natural organic compound, is a kind of pharmaceutical intermediate with a pleasant smell and contributes to the aroma of essential oils.|
|S5570||Arachidic acid||Arachidic acid (eicosanoic acid, Icosanoic Acid) is a natural saturated fatty acid used for the production of detergents, photographic materials and lubricants.|
|S5335||Corey Lactone Diol||Corey Lactone Diol is a pharmaceutical intermediate.|
|S5338||L(-)-Sorbose||L(-)-Sorbose (L(-)-Sorbopyranose) is a ketose sugar that is commonly used in the commercial synthesis of ascorbic acid.|
|S5337||Rauwolscine hydrochloride||Rauwolscine hydrochloride (Isoyohimbine, α-Yohimbine, corynanthidine) is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM.|
|S5342||Dihydrojasmone||Dihydrojasmone, belonging to the family of ketones, is an aroma compound for perfumery uses.|
|S5347||2-Phenylethylamine||2-Phenylethylamine (β-Phenylethylamine, benzeneethanamine, β-aminoethylbenzene) is a natural monoamine alkaloid that functions as a monoaminergic neuromodulator or a neurotransmitter in the human central nervous system.|
|S5348||Pherocon (4-(4-Acetoxyphenyl)-2-butanone)||Pherocon (4-(4-Acetoxyphenyl)-2-butanone, 4-(p-Acetoxyphenyl)-2-butanone, 4--(3-Oxobutyl)phenyl acetate) is a standard melon fly attractant for detection programs.|
|S3792||Guggulsterone E&Z||Guggulsterone is one of the active constituent of Commiphora mukul. It occurs in two isomeric forms, namely Z-GS and E-GS. Guggulsterone act as antagonist ligands for the bile acid receptor, farnesoid X receptor, and as active ingredients responsible for the hypolipidemic activity.|
|S5584||Citronellol||Citronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. Citronellol can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. Citronellol also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells.|
|S5380||7-Hydroxyflavone||7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2. It also has excellent antioxidant properties and great potential to be applied as medicines.|
|S5381||Behenic Acid||Behenic Acid (docosanoic acid) is a long-chain saturated fatty acid that exists naturally as a triglyceride in canola. It act as a lubricant that helps restore the skin's natural oils and improve overall levels of hydration.|
|S3864||Dulcitol||Dulcitol (Galactitol, D-Galactitol, Dulcose) is a naturally occurring product of plants obtained following reduction of galactose.|
|S3865||Taurochenodeoxycholic acid||Taurochenodeoxycholic acid (Taurochenodeoxycholate, TCDCA, Chenodeoxycholyltaurine), a bile acid formed in the liver of most species, is used as a cholagogue and choleretic.|
|S3981||Sinapinic Acid||Sinapinic acid (Sinapic acid) is a small naturally occurring hydroxycinnamic acid which belongs to phenylpropanoid family and commonly used as matrix in MALDI mass spectrometry. Sinapinic acid (Sinapic acid) acts as an inhibitor of HDAC, with IC50 of 2.27 mM, and also inhibits ACE-I activity.|
|S5151||Gypenoside||Gypenoside (GP) is the predominant effective component of Gynostemma pentaphyllum and possesses capacities against inflammation and oxidation.|
|S3962||Dihydroactinidiolide||Dihydroactinidiolide is known to be a bioactive molecule in animals. It is a component of pheromones in insects, such as red fire ants and in mammals such as the Cat and the Red Fox.|
|S3955||Uric Acid||Uric Acid (2,6,8-Trioxypurine, 2,6,8-Trihydroxypurine, 2,6,8-Trioxopurine), a normal component of urine, is a product of the metabolic breakdown of purine nucleotides.|
|S3789||Tiglic acid||Tiglic acid (Cevadic acid, Sabadillic acid, Tiglinic acid) is a monocarboxylic unsaturated organic acid found in croton oil and in several other natural products. It is used in making perfumes and flavoring agents.|
|S3796||Rebaudioside A||Rebaudioside A (Stevia Extract, Reb A, Glycoside A3, Stevioside A3), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste. Rebaudioside A is a steviol glycoside, α-glucosidase inhibitor with IC50 of 35.01 μg/ml.can inhibit ATP-sensitive K+-channels.|
|S3812||Monocrotaline||Monocrotaline (MCT, Crotaline) is an 11-membered macrocyclic pyrrolizidine alkaloid (PA) that causes a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension, and cor pulmonale.|
|S3679||Flavanone||Flavanones (2,3-Dihydroflavone, 4-Flavanone, 2-Phenyl-4-chromanone, 2-Phenylchroman-4-one) show strong antioxidant and radical scavenging activity, and appear to be associated with a reduced risk of certain chronic diseases, the prevention of some cardiovascular disorders, and certain kinds of cancer. Flavanones also exhibit antiviral, antimicrobial, and anti-inflammatory activities, beneficial effects on capillary fragility, and an ability to inhibit human platelet aggregation, anti-ulcer, and anti-allergenic properties.|
|S5107||Riboflavin phosphate sodium||Flavin mononucleotide (riboflavin-5'-phosphate, FMN) is a biomolecule produced from riboflavin (vitamin B2) by the enzyme riboflavin kinase and functions as prosthetic group of various oxidoreductases including NADH dehydrogenase as well as cofactor in biological blue-light photo receptors.|
|S4955||Acetosyringone||Acetosyringone (Acetosyringenin) is a phenolic natural product with analgesic, antipyretic and anti-inflammatory actions.|
|S3652||3-Nitropropionic acid||3-Nitropropionic acid (β-Nitropropionic Acid, 3-NP) is an irreversible inhibitor of mitochondrial respiratory Complex II succinate dehydrogenase, resulting in energy depletion through disruption of the electron transport chain.|
|S5513||Calcium D-saccharate tetrahydrate||Calcium D-saccharate tetrahydrate (Calcium Saccharate, D-Saccharic acid calcium salt, D-Glucaric acid calcium salt) is the calcium salt form of glucaric acid, a natural substance found in many fruits and vegetables, with potential anti-cancer property.|
|S5518||D-Glucose 6-phosphate disodium salt||D-Glucose 6-phosphate disodium salt is the disodium salt form of D-Glucose 6-phosphate, a common form of glucose within the cell, participating in two major metabolic pathways: glycolysis and the pentose phosphate pathway. It can be coverted to glycogen or starch for storage.|
|S5575||2-Benzoxazolinone||2-Benzoxazolinone (BOA, 2-Hydroxybenzoxazole), a well-known allelochemical with strong phytotoxicity, is a potential herbicidal candidate and probably functions via interfering with auxins or disrupting membrane integrity.|
|S5579||Chelidonic acid||Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid) is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals. Chelidonic acid inhibits IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. Chelidonic acid is also an inhibitor of glutamate decarboxylase with Ki of 1.2 μM.|
|S5595||3-Carene||3-Carene (Carene, Delta-3-Carene) is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene have potent pharmacological effects on COX-2 overexpression and LPS-induced migration of Raw264.7 macrophages. 3‐carene is shown to significantly stimulate the activity and expression of alkaline phosphatase, an early phase marker of osteoblastic differentiation.|
|S5376||Decyl aldehyde||Decyl aldehyde (Decanal, Capraldehyde, Decanaldehyde) is a naturally occuring organic compound that is used in fragrances and flavoring.|
|S5551||6-Paradol||6-Paradol is a minor constituent of ginger, mainly formed from 6-gingerol via 6-shogaol, and exhibits a variety of biological activities including anti-cancer, anti-inflammatory, and anti-oxidative activities. Paradol is an inhibitor of cyclooxygenase (COX)-2.|
|S5379||Fenchyl Alcohol||Fenchyl Alcohol is used as a flavoring agent to provide a pine, herbal, lemon, or floral taste to food and drink.|
|S5237||Dihydroartemisinic acid||Dihydroartemisinic acid is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinal herb that is widely used to treat Malaria.|
|S5516||Ellagic Acid hydrate||Ellagic acid is a potent inhibitor of protein kinase CK2 with IC50s of 0.04, 2.9 and 3.5 μM for CK2, Lyn and PKA respectively. It shows potent antioxidant, anti-mutagenic and antidepressant properties.|
|S5471||Monotropein||Monotropein, an iridoids glycoside isolated from the roots of Morinda officinalis How, has been demonstrated to exhibit anti-inflammatory activity.|
|S5467||Asarinin||Asarinin (Sesamin, Fagarol, Pseudocubebin, Episesamin, Eleutheroside B4), isolated as a racemate from the shrub Zanthoxylum alatum, is usually used as a dietary fat-reduction supplement.|
|S5455||Akebia saponin D||Akebia saponin D (Asperosaponin VI), the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone fractures.|
|S5529||Galangin||Galangin (3,5,7-trihydroxyflavone; Norizalpinin), a naturally occuring flavonoid found in herbs, is a well-known antioxidant and also an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor.|
|S5468||Kaempferol-3-O-glucorhamnoside||Kaempferol 3-neohesperidoside (Kaempferol 3-neohesperidoside), isolated from the herbs of Delphinium grandiflorum L., has insulin-like properties in terms of glucose lowering.|
|S5465||Morroniside||Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption. Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.|
|S5463||Curcurbitacin IIA||Curcurbitacin IIA (Cucurbitacin Iia, CuIIa, Hemslecin A, Dihydrocucurbitacin Q1) is the major active component of the Helmseya amabilis root and is known to have antiviral and anti-inflammatory effects.|
|S5469||Bavachin||Bavachin (Corylifolin) is a phytoestrogen purified from natural herbal plants such as Psoralea corylifolia. It acts as a weak phytoestrogen by binding and activating the ER.|
|S5456||Isobavachalcone||Isobavachalcone (Corylifolinin), a naturally occurring chalcone compound derived from the seeds of Psoralea corylifolia L., has long been used in traditional Chinese medicine as anthelmintic, antibacterial, aphrodisiac, astringent and antiplatelet agent.|
|S5512||Juglone||Juglone (Regianin, 5-Hydroxy-1,4-naphthoquinone), a natural naphthoquinone found in the black walnut and other plants, has moderate antifungal activity and growth-stimulating effects to many types of plants. It sometimes can be used as an herbicide, as a dye for cloth and inks, and as a coloring agent for foods and cosmetics.|
|S3880||Schisantherin A||Schisantherin A (Gomisin C, Schisanwilsonin H, Arisanschinin K) is a dibenzocyclooctadiene that exhibits anti-tussive, sedative, anti-inflammatory, anti-osteoporotic, neuroprotective, cognition enhancing, and cardioprotective activities. Schisantherin A inhibits p65-NF-κB translocation into the nucleus by IκBα degradation.|
|S3882||Brassinolide||Brassinolide, a plant steroid isolated from Brassica napus pollen, promotes cell elongation and cell devision and thus regulates plant growth and development.|
|S2291||Diosgenin||Diosgenin is a steroid sapogenin and the precursor for the semisynthesis of progesterone which in turn was used in early combined oral contraceptive pills; A weak PDE inhibitor.|
|S3776||Sophoricoside||Sophoricoside (SOPH) is an isoflavone isolated from Sophora japonica (Leguminosae) with numerous pharmacological effects, including anti- inflammatory, anti-cancer and immunosuppressive effects.|
|S5249||Coptisine chloride||Coptisine (Q-100696, NSC-119754) is an isoquinoline alkaloid isolated from Coptidis Rhizoma with anti-diabetic, antimicrobial, antiviral, anti-hepatoma, and anti-leukemia effects. Coptisine chloride is an efficient uncompetitive IDO inhibitor with IC50 value of 6.3 μM and Ki value of 5.8 μM.|
|S8279||Shikonin (C.I. 75535)||Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.|
|S3822||Schisandrin A||Schisandrin A (Sch A, Deoxyschizandrin, Wuweizisu A) is an active component of Schisandrae Fructus with liver-protective, antitumor, and antioxidant activities. It is an agonist of the adiponectin receptor 2 (AdipoR2) with the IC50 value of 3.5 μM.|
|S4738||Arctiin||Arctiin (Arctigenin-4-Glucoside, NSC 315527) acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.|
|S8132||Deguelin||Deguelin, a natural product isolated from plants in the Mundulea sericea family, is an PI3K/AKT Inhibitor.|
|S3832||Euphorbiasteroid||Euphorbiasteroid (Euphorbia factor L1), a component of Euphorbia lathyris L., inhibits adipogenesis of 3T3-L1 cells through activation of the AMPK pathway and induces HL-60 cells to apoptosis via promoting Bcl-2/Bax apoptotic signaling pathway in a dose-dependent manner. Euphorbiasteroid is a tricyclic diperpene of Euphorbia lathyris L., inhibits tyrosinase, and increases the phosphorylation of AMPK, with anti-cancer, anti-virus, anti-obesity and multidrug resistance-modulating effect.|
|S4884||Trans-Zeatin||Trans-Zeatina ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing. Trans-Zeatin inhibits UVB-induced MMP-1 expression, c-Jun activation and phosphorylation of ERK, JNK and p38 MAP kinases (MAPKs) dose-dependently.|
|S7409||Anisomycin||Anisomycin (Flagecidin, Wuningmeisu C) is a bacterial antibiotic isolated from Streptomyces griseolus, which inhibits protein synthesis, and also act as a JNK activator. Anisomycin upregulates autophagy and increases apoptosis.|
|S3818||Tectoridin||Tectoridin (Shekanin), an isoflavone isolated from flowers of Pueraria thunbergiana, has several pharmacological effects including anti-cancer, anti-inflammatory, antioxidant, and hepatoprotectivy.|
|S3841||Eleutheroside B||Eleutheroside B (syringin, Syringoside, Lilacin) is a phenylpropanoid glycoside first isolated from A. senticosus and has neuroprotective, tonic, adaptogenic, and immune-modulating properties.|
|S3845||Panaxadiol||Panaxadiol (20(R)-Panaxadiol) is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.|
|S3848||Hydroxytyrosol Acetate||Hydroxytyrosol acetate (HTy-Ac), an extra virgin olive oil (EVOO) polyphenol, exhibits antioxidant and anti-inflammatory effects.|
|S3778||Patchouli alcohol||Patchouli alcohol (Patchoulol, Patchouli camphor), an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.|
|S3912||Cephalotaxine||Cephalotaxine is a naturally occurring alkaloid which is the structural motif of a number of compounds and has shown promising anti-cancer properties.|
|S3874||Curcumenol||Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.|
|S3877||Lysionotin||Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities.|
|S3816||Dehydroevodiamine||Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.|
|S3906||Astragalus polyphenols||Astragalus is a wonderful immune enhancing herb that has strong anti-viral activity and produces extra interferon in the body. It contains rich polyphenol with various effects including antioxidant and antiinflammatory actions.|
|S3907||Bulleyaconi cine A||Bulleyaconi cine A (Bulleyaconitine A, BLA) is an active ingredient of Aconitum bulleyanum plants and classified as an "aconitine-like" alkaloid. It is a potent use-dependent blocker for both Nav1.7 and Nav1.8 Na+ currents.|
|S3922||(-)-epigallocatechin||(-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions.|
|S3915||Gracillin||Gracillin, a kind of steroidal saponin isolated from the root bark of wild yam Dioscorea nipponica, has been reported to exert antitumor activity.|
|S3916||Macranthoidin B||Macranthoidin B (Macranthoiside I) is a major bioactive saponin in rat plasma after oral administration of extraction of saponins from Flos Lonicerae.|
|S3920||7β-Hydroxylathyrol||7β-Hydroxylathyrol (7beta-Hydroxylathyrol, 7-Hydroxylathyrol) is natural occuring product extracted from the seeds of Euphorbia lathyris L.|
|S3875||Alpinetin||Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity.|
|S3884||Jatrorrhizine||Jatrorrhizine (Neprotin, Yatrorizine), one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.|
|S3808||Mangiferin||Mangiferin (Alpizarin, Chinomin, Hedysarid) is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements. Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50.|
|S3813||Bakuchiol||Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.|
|S3837||Echinocystic acid||Echinocystic acid (EA), a natural triterpone enriched in various herbs, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects.|
|S3844||Rosavin||Rosavin, a cinnamyl alcohol glycoside found in the plant Rhodiola rosea, possesses antidepressant and anxiolytic activities.|
|S3782||Neomangiferin||Neomangiferin (Mangiferin 7-glucoside), a natural xanthone C-glycoside mainly obtained from the well-known traditional Chinese medicine rhizoma of Anemarrhena asphodeloides, exhibits antidiabetic activity and antiosteoporotic action.|
|S3784||Obacunone (AI3-37934)||Obacunone (AI3-37934, CCRIS 8657), a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.|
|S3786||Glabridin||Glabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.|
|S3932||Astilbin||Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.|
|S3760||Stachydrine hydrochloride||Stachydrine is isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. It has potent anti-metastatic activity and cardioprotective effects. Stachydrine hydrochloride is the major active constituent of Herba Leonuri, which is a potential therapy for cardiovascular diseases. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities.|
|S3764||Isoferulic Acid||Isoferulic acid (Hesperetic acid, Hesperetate, Isoferulate), a major active ingredient of Cimicifuga heracleifolia, shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties. Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is a cinnamic acid derivative that has antidiabetic activity. Isoferulic acid binds to and activates α1-adrenergic receptors (IC50=1.4 µM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use.|
|S5101||Tabersonine hydrochloride||Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.|
|S3815||Mogroside V||Mogroside V is a natural cucurbitane glycoside which has a sweetening strength of 250 times that of sucrose and is derived from mature fruit of luo-han-guo (Siraitia grosvenorii, monk fruit).|
|S3819||Decursinol angelate||Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.|
|S3820||Dehydroevodiamine hydrochloride||Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.|
|S3825||Glycitin||Glycitin (Glycitein-7-β-O-glucoside), a natural isoflavone isolated from legumes, has antibacterial, antiviral and estrogenic activities and may exerts preventative effects on alcoholism, cardiovascular and cerebrovascular diseases and some types of cancer.|
|S3826||Hydroxytyrosol||Hydroxytyrosol (3,4-dihydroxyphenylethanol) is one of the main phenolic components of olive oil with excellent antioxidant, antimicrobial and anticarcinogenic activities.|
|S3827||Royal jelly acid||Royal jelly acid (10-Hydroxy-trans-2-decenoic acid, 10H2DA) is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity.|
|S3829||Isoalantolactone||Isoalantolactone, one of the major sesquiterpene lactone compounds, is isolated from the roots of Anula helenium and possesses multiple biological activities including antifungal, anthelmintic, antimicrobial, anti-inflammatory, antitrypanosomal activities and antiproliferative effects on several cancer cell lines, such as colon, melanoma, ovary, prostate, lung, and leukemia. Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent.|
|S3836||6-Gingerol||6-Gingerol is the active constituent of fresh ginger known to exhibit a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.|
|S3838||Carnosic acid||Carnosic acid (Salvin) is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.|
|S3840||Baohuoside I||Baohuoside I (Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.|
|S5104||Tea polyphenol||Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities.|
|S3614||Lupeol||Lupeol (Clerodol, Monogynol B, Fagarasterol, Farganasterol) is a significant lupane-type triterpene represented in the plant, fungi and animal kingdoms with anticancer, antiprotozoal, chemopreventive and anti-inflammatory properties.|
|S8291||Atractylenolide I||Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects.|
|S4742||Rebaudioside C||Rebaudioside C (Dulcoside B) belongs to the family of Steviol Glycosides. It is a natural constituent of the plant Stevia rebaudiana Bertoni and used as natural sweeteners to diabetics and others on carbohydrate-controlled diets.|
|S4739||Oxyresveratrol||Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene), a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.|
|S8318||Alantolactone||Alantolactone (helenin, helenine, Eupatal), a naturally occurring eudesmane-type sesquiterpene lactone (SL), could induce activin/SMAD3 signaling and disrupt Cripto-1/activin receptor type II A interaction.|
|S4708||Palmitoylethanolamide||Palmitoylethanolamide (PEA, Palmidrol, N-palmitoylethanolamine) is an endogenous fatty acid amide and selectively activates PPAR-α in vitro with an EC50 value of 3.1±0.4 μM.|
|S7582||Anacardic Acid||Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.|
|S8036||Butein||Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR.|
|S4916||Cyanidin Chloride||Cyanidin Chloride, a natural flavonoid abundant in fruits and vegetables, is an agonistic ligand for liver X receptor alpha and beta with EC50 of 3.5 μM and 125.2 μM, respectively.|
|S0933||Melittoside||Melittoside, a natural compound, is the first iridoid to be found to contain two molecules of sugar (glucose).|
|S0935||Isomangiferin||Isomangiferin is a natural compound that inhibits virus replication within cells showing antiviral effects.|
|S0942||Oxypaeoniflorin||Oxypaeoniflorin is a natural compound derived from Radix Paeoniae Rubra and Radix Paeoniae Alba.|
|S0953||Neocindilide||Neocindilide (Sedanolide), a natural compound found in edible umbelliferous plants, exhibits anti-inflammatory and antioxidant activities.|
|S0959||Alismoxide||Alismoxide is a natural product with anti-inflammatory effects.|
|S2253||3-Indolebutyric acid (IBA)||3-Indolebutyric acid(IBA) is a plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products.|
|S2259||Aloe-emodin||Aloe-emodin (NSC 38628, Rhabarberone) is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71.|
|S2379||Dioscin||Dioscin (Collettiside III, Saponin) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp, showing antitumor activities.|
|S2261||Andrographolide||Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.|
|S2266||Asiatic Acid||Asiatic acid (Dammarolic acid, Asiantic acid) is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing.|
|S2271||Berberine chloride (NSC 646666)||Berberine chloride (NSC 646666, Natural Yellow 18) is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.|
|S2392||Sesamin||Sesamin (Fagarol, Fsesamin), a lignan isolated from the bark of Fagara plants and from sesame oil, exhibits various health benefits.|
|S2448||Gambogic Acid||Gambogic Acid (Guttatic Acid, Guttic Acid, Beta-Guttiferrin) activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.|
|S2281||Chrysin||Chrysin (NSC 407436) is a naturally occurring flavone chemically extracted from the blue passion flower (Passiflora caerulea).|
|S2285||Cryptotanshinone||Cryptotanshinone is a STAT3 inhibitor with IC50 of 4.6 μM in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5. Cryptotanshinone induces ROS-dependent autophagy and mitochondria-mediated apoptosis.|
|S2385||Hordenine||Hordenine (N,N-dimethyl-4-hydroxyphenylethylamine) is a phenylethylamine alkaloid with antibacterial and antibiotic properties.|
|S2395||Rheochrysidin||Rheochrysidin (Physcione) is an anthraquinone from roots of Rheum officinale Baill.|
|S2297||Ergosterol||Ergosterol is a sterol and a biological precursor (a provitamin) to vitamin D2.|
|S2298||Fisetin||Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.|
|S2399||Dihydromyricetin||Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.|
|S2301||Genistin (Genistoside)||Genistin (Genistoside, Genistine, Genistein 7-glucoside, Genistein glucoside) is an isoflavone found in a number of dietary plants like soy and kudzu. Genistin attenuates cellular growth and promotes apoptotic cell death breast cancer cells through modulation of Estrogen Receptor α (ERα) signaling pathway.|
|S2400||Rheic Acid||Rhein (Monorhein, NSC 38629, Rheinic) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is an FTO (mRNA N6-methyladenine demethylase) inhibitor and also inhibits AlkB repair enzymes.|
|S2303||Gossypol Acetate||Gossypol Acetate (Gossypol Acetic acid, Pogosin, AT101) is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.|
|S2402||Cyclovirobuxine D||Cyclovirobuxine D (Cyclovirobuxin D, Cyclovirobuxine, Bebuxine, CVB-D) is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia.|
|S2306||Gynostemma Extract||Gynostemma Extract (Gynostemma Pentaphyllum, Gypenoside) is a saponins extract derived from the Gynostemma pentaphyllum.|
|S2308||Hesperetin||Hesperetin is a bioflavonoid and, to be more specific, a flavanone.|
|S2405||Sophocarpine||Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.|
|S2406||Chrysophanic Acid||Chrysophanic Acid (Chrysophanol) a natural anthraquinone isolated from Dianella longifolia, is a EGFR/mTOR pathway inhibitor.|
|S2312||Icariin||Icariin is a cGMP-specific PDE5 inhibitor with IC50 of 0.432 μM, 167-fold more selective for PDE5 than PDE4.|
|S2407||Curcumol||Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities.|
|S1450||Nanchangmycin||Nanchangmycin is a polyether antibiotic with similar structure to dianemycin and is very active against a broad spectrum of harmful nematodes and insects but not for mammals and plants.|
|S2319||Limonin||Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.|
|S2415||Astragaloside A||Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases.|
|S2322||(+)-Matrine||Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.|
|S2326||Myricetin||Myricetin, a natural flavonoid with antioxidant and anti tumor properties, is a novel inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells. It also inhibits PI3Kγ with Kd of 0.17 μM.|
|S2327||Myricitrin||Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effects.|
|S2335||Oridonin (NSC-250682)||Oridonin (Isodonol, Rubescenin, NSC-250682), a diterpenoid purified from Rabdosia rubescens, is a traditional agent with antitumor, anti-bacterial and anti-inflammatory effects. Oridonin inhibits AKT1 and AKT2 kinase activity with IC50 of 8.4 μM and 8.9 μM, respectively.|
|S2341||(-)-Parthenolide||(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.|
|S2343||Phlorizin||Phlorizin (Phloridzin) is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phlorizin is a non-selective SGLT inhibitor with Ki of 300 nM and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.|
|S2349||Rutaecarpine||Rutaecarpine (Rutecarpine) is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs; a new class of COX-2 inhibitor.|
|S2355||Sclareolide||Sclareolide (Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia sclarea, Salvia yosgadensis, and cigar tobacco.|
|S2356||Shikimic Acid||Shikimic acid (Shikimate), more commonly known as its anionic form shikimate, is an important biochemical intermediate in plants and microorganisms.|
|S2361||Stigmasterol||Stigmasterol is an unsaturated plant sterol that exhibits anti-cancer, anti-pyretic, anti-inflammatory and immune-modulating effects.|
|S2371||Vanillylacetone||Vanillylacetone (NSC 15335) is similar in chemical structure to other flavor chemicals such as vanillin and eugenol and is used as a flavor additive in spice oils and in perfumery to introduce spicy aromas. Vanillylacetone (Zingerone) alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells.|
|S2372||Xanthone||Xanthone (Genicide) is an organic compound, which can be prepared by the heating of phenyl salicylate.|
|S0905||Syringaresnol-4-O-beta-D-apiofuranosy||Syringaresnol-4-O-beta-D-apiofuranosy is a natrual product isolated from the bark of Albizzia myriophylla.|
Dammarenediol-II, a precursor of triterpenoid saponin biosynthesis, inhibits VEGF-induced stress fiber formation and vascular endothelial-cadherin disruption, both of which play critical roles in modulating endothelial permeability.
Stigmasta-4,22-dien-3-one (Stigmastadienone), a bioactive compound isolated from <i>Isodon rugosus</i>, has physiological effects on many targets.
Alpha-Solanine, one of the major steroidal glycoalkaloids in potatoes, inhibits growth and induces apoptosis in cancer cells.
|E2766||Primulic acid I||
Primulic acid I (primulasaponin I or saponin PS4), the main triterpene saponin from primula roots, increases the production of airway secretions, making phlegm less thick and easier to expel.
|E2767||Primulic acid II||
Primulic acid II (Primulasaponin II) is a kind of natural triterpene saponin.
Aloenin B is a natural component isolated from the herbs of <i>Aloe arborescens</i> Mill.
Epipodophyllotoxin, an antiproliferative agent against cancer cells isolated from American mayapple <i>Podophyllum peltatum</i>, inhibits mitotic spindle assembly in vitro.
Glyasperin A, a bioactive compound isolated from liquorice (Glycyrrhiza species) and considered as the best molecule from liquorice, is useful against COVID-19.
Mogroside III-E, a cucurbitane-type compound isolated from <i>Siraitia grosvenorii</i>, inhibits NO release with anti-fibrotic activity.
Monascin, a kind of azaphilonoid pigments extracted from <i>Monascus pilosus</i>-fermented rice (red-mold rice), exhibits anti-tumor-initiating and anti-inflammatory activities with oral administration.
Dulcoside A, a natural component isolated from <i>Stevia rebaudiana</i>, is often advertised as a sweetener.
Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels.
Cubebin, a dibenzylbutyrolactone lignan isolated from <i>Piper cubeba</i>, shows promising protective activity in scopolamine-induced spatial memory impairment in mice.
Hinokinin (Cubebinolide), an bioactive lignin, is reported to show wide range of pharmacological activities.
|E2778||Ankaflavin||Ankaflavin, isolated from Monascus-Fermented red rice, is a PPARγ agonist with anti-inlfammatory activity.|
5-Demethylnobiletin (2-(3,4-dimethoxyphenyl)-6,7,8-trimethoxychromen-4-one) is a unique flavonoid found in citrus fruits with potential chemopreventive effect against human cancers.
|E2780||Cannabichromene||Cannabichromene (DL-cannabichromene) is a 2,2-dimethyl-2H-chromene derivative. Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1), it selectively reduces inflammation-induced hypermotility in vivo in a manner that is not dependent on cannabinoid receptors or TRPA1.|
Kahweol is one of the consituents of the coffee from <i>Coffea arabica</i> with anti-inflammatory anti-angiogenic, and anti-cancerous activities.
Cannabisin B, a lignanamide from hempseed, possesses considerable antiproliferative activity.
Hinokinin, a kind of lignans extracted from the fruits of <i>Piper cubeba</i>, possesses the anthelmintic activity.
3alpha-Hydroxytirucalla-7,24-dien-21-oic acid, a triterpene isolated from the resin of <i>Canarium schweinfurthiiand</i>, is an isomer of triterpene 3α-hydroxytirucalla-7,24-dien-21-oic acid.
Thiocolchicine, a sulfur derivative of a natural glycoside of colchicine, acts as a muscle relaxant and has no side effects listed with colchicine.
Taraxerol is isolated from <i>Abroma augusta</i> L., and has anti-inflammtory and anti-cancer effects.
Benzoyloxypaeoniflorin, isolated from the roots of <i>Paeonia suffruticosa</i>, is a tyrosinase inhibitor against mushroom tyrosinase with IC50 of 0.453 mM, also is NF-κB Inhibitor and contributes to blood circulation improvement through its inhibitory effect on both platelet aggregation and blood coagulation.
(-)-Butin is the S enantiomer of Butin that is a major biologically active flavonoid isolated from the heartwood of <i>Dalbergia odorifera</i>, with strong antioxidant, antiplatelet and anti-inflammatory activities.
Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural alkaloid present in Cinchona bark, with antimalarial activity.
Cyclosporin C, a fungal metabolite found in <i>T. inflatum</i>, has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties.
Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively.
Dryocrassin ABBA (Dryocrassin) is a flavonoid natural product derived from <i>Dryopteris crassirhizoma</i>, with antiviral and antibacterial activities.
|E2793||Ganoderic acid F||
Ganoderic acid F, a ganoderic acid, exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium signaling, and endoplasmic reticulum stress.
Garcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell.
Gartanin is a natural xanthone of mangosteen, with antioxidant, anti-inflammatory, antifungal, neuroprotective and antineoplastic properties.
Ginsenoside F3, a component of PPTGs (an minor saponin in the leaves of <i>Panax ginseng</i>), has immunoenhancing activity by regulating production and gene expression of type 1 cytokines (IL-2, IFN-gamma) and type 2 cytokines (IL-4 and IL-10).
Gitogenin, a natural steroid isolated from the whole plant of <i>Tribulus longipetalus</i>, is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50s of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively.
Gomisin G, an ethanolic extract of the stems of <i>Kadsura interior</i>, exhibits potent anti-HIV activity with EC50 and therapeutic index (TI) values of 0.006 μg/mL and 300, respectively.
Hederasaponin B, a bioactive compound isolated from <i>Hedera helix</i>, has broad-spectrum antiviral activity against various subgenotypes of Enterovirus 71 (EV71).
Hyperforin, a natural compound extracted from <i>Hypericum perforatum</i>, promotes adipose tissue thermogenesis to suppress obesity.
Indaconitine (15-Deoxyaconitine) is an active ingredient from the rhizomes of Aconitum plants.
Iridin, one of the main bioactive components isolated from <i>Belamcanda chinensis</i> (L.) DC, exerts various pharmacological activities, such as anti-inflammation, antioxidant, and antitumor.
Isoanhydroicaritin is a flavonoid isolated from the dried roots of <i>S. flavescens</i>.
Isoescin IA, a triterpenoid saponin isolated from the seeds of <i>Aesculus chinensis</i>, has anti-HIV-1 protease activity.
D-iditol is the D-enantiomer of iditol, which is a sugar alcohol that accumulates in galactokinase deficiency.
Robinin, a flavonoid fraction of <i>Vigna unguiculata</i> leaf, inhibits upregulated expression of TLR2 and TLR4.
L-(+)-Ergothioneine (Ergothioneine), an imidazole-2-thione derivative of histidine betaine synthesized by certain bacteria and fungi, is generally considered an antioxidant.
|E2760||Euscaphic acid||Euscaphic acid, a DNA polymerase inhibitor and a triterpene isolated from roots of the R. alceaefolius Poir, inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50s of 61 and 108 μM, also induces apoptosis.|
Dihydrokaempferol has antioxidant and anti-inflammatory, improving pancreatic damage and hepatoprotective effects, also can effectively promote cell apoptosis.
|E0538||Rhodionin||Rhodionin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor, exhibiting potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE), and potent DPPH free radical scavenging activities.|
Lycobetaine is a quaternary phenanthridinium alkaloid from Lycoris radiata of the Amaryllidaceae family, with significant cytotoxic activity against Lewis lung carcinoma.
Isoneochamaejasmin A, a biflavonoid isolated from the dried root of <i>Stellera chamaejasme</i> L., is a widely used traditional Chinese medicine.
|S6353||Withanolide A||Withanolide A is a natural compound isolated from the indian herbal drug Ashwagandha (root of Withania somnifera). Withanolide A can regenerate neurites and reconstruct synapses in severely damaged neurons.|
|S6365||Cnidicin||Cnidicin is a coumarin isolated from the root of Angelica koreana that inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells.|
|S5890||Epibetulinic acid||Epibetulinic acid is a natural product isolated from the root bark of Maytenus cuzcoina and the leaves of Maytenus chiapensis with anti-inflammatory activity. Epibetulinic acid inhibits NO and prostaglandin E2 (PGE2) production in mouse macrophages stimulated with bacterial endotoxin with IC50 of 0.7 μM and 0.6 μM, respectively.|
Polygodial (Poligodial; Tadeonal) is an antifungal potentiator. Polygodial is a sesquiterpene with anti-hyperalgesic properties.
|E2750||Cepharanoline||Cepharanoline is a natural product found in Stephania cephalantha and Stephania rotunda.|
(+)-beta-Cedrene is a natural product found in <i>Widdringtonia whytei</i>, <i>Helichrysum odoratissimum.</i>
(-)-alpha-cedrene is a sesquiterpene constituent of cedarwood oils, with anti-leukemic, antimicrobial and anti-obesity activities.
Polyphyllin H has been widely used in traditional Chinese medicinal preparations to treat inflammation, fracture and convulsion.
|E2754||12alpha-Hydroxyrotenone||12a-Hydroxyrotenone is a natural product found in Pachyrhizus erosus, Millettia ferruginea.|
|E2707||Obtusifoliol||Obtusifoliol is a natural product found in Euphorbia chamaesyce or Euphorbia nicaeensis.|
|E2708||Alpha-Chaconine||Alpha-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages.|
|E2709||Halofuginone hydrobromide||Halofuginone (RU-19110) hydrobromid, a febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity.|
Ganoderiol F is a natural product found in <i>Ganoderma lipsiense</i>, <i>Ganoderma leucocontextum</i>, and <i>Ganoderma sinense</i>.
Pseudohypericin and its congener Hypericin are the major hydroxylated phenanthroperylenediones present in Hypericum species. Pseudohypericin shows anti-HIV activity.
Cirsimarin is a potent antilipogenic flavonoid isolated from <i>Microtea debilis</i>. Cirsimarin exerts potent antilipogenic effect and decreases adipose tissue deposition in mice. The lipolytic activity of Cirsimarin resulting from both its antagonist activity on <b>adenosin A1 receptor</b> and its inhibitory effect on <b>phosphodiesterase</b>.
Polygalaxanthone XI, a xanthone glycoside isolated from the cortexes of <i>Polygala tenuifolia</i>, can be used in the study of expectorant, and tranquilizing agent.
Bixin, isolated from the seeds of <i>Bixa orellana</i>, is a carotenoid, possessing anti-inflammatory, anti-tumor and anti-oxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation and reactive oxygen species (ROS) generation.
Solanidiene (Solanthrene) is isolated from the leaves of <i>S. tuberosum</i>.
Solanidine is a cholestane alkaloid isolated from several potato species including Solanum demissum, Solanum acaule, and Solanum tuberosum. Solanidine can inhibit proliferation and exhibit obvious antitumor effect.
|E2712||Ganoderic acid TR||
Ganoderic acid TR is a broad-spectrum inhibitor against <b>influenza neuraminidases (NAs)</b>, particularly H5N1 and H1N1 neuraminidases. The IC<sup>50</sup> values of 10.9 and 4.6 μM, respectively.
SSF-109 is a broad-spectrum fungicide which has protective activity against plant disease. SSF-109 inhibits the biosynthesis of ergosterol at the 14α-demethylation step in <i>Botrytis cinerea</i>.
Dieckol is a phlorotannin isolated from a brown <i>alga Ecklonia</i> cava which exhibits antioxidant, hepatoprotective and anticoagulant activities. Dieckol has a role as a metabolite, a radical scavenger, an <b>EC 220.127.116.11 (alpha-glucosidase)</b> inhibitor, a hepatoprotective agent and an anticoagulant. Dieckol is a phlorotannin, an aromatic ether and an oxacycle.
Mahanimbine is an orally active alkaloid from curry leaves. Mahanimbine inhibits progression of high-fat diet (HFD)-induced metabolic complications in mice.
Halleridone is a natural product found in <i>Teucrium decipiens</i> or <i>Abeliophyllum distichum</i>.
QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18.
Fabacein is a natural product found in <i>Marah oregana</i> and <i>Marah fabacea</i>.
Larixyl acetate, a main constituent of larch resin, is able to selectively inhibit <b>TRPC6</b> function.
Cholesta-4,6-dien-3beta-ol is a cholestanoid.
Nevadensin is a naturally occurring selective inhibitor of <b>human carboxylesterase 1 (hCE1)</b> with an IC50 of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive.
Sempervirine is an indole alkaloid isolated from <i>Gelsemium sempervirens</i> with anti-tumor activities.
|E2730||Isoforskolin||Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis.|
Isorhapontin is a glycosidefound in <i>Rheum undulatum</i>, <i>Veratrum taliense</i>.
Luteolin-4'-glucoside is a natural product found in <i>Lathyrus pratensis</i>.
Diphlorethohydroxycarmalol (DPHC) is a natural product found in <i>Ishige okamurae</i> and <i>Carpophyllum maschalocarpum</i>.
Tripchlorolide is a natural product found in <i>Celastraceae</i> and<i> Tripterygium wilfordii</i>.
26-Deoxycimicifugoside is a triterpene xylosides isolated from <i>Cimicifuga racemosa</i>.
Pinostilbene is a major metabolite of Pterostilbene. Pinostilbene exhibits inhibitory effects on colon cancer cells.
Theaflavin-3-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner.
Quercetin 3-rutinoside-7-glucoside is a natural product found in <i>Ranunculus hederaceus </i>or<i>Nicotiana cavicola</i>.
L-Isopulegol ((-)-Isopulegol; Isopulegol) is a p-menthane monoterpenoid found in <i>Teucrium divaricatum</i>, <i>Teucrium cyprium</i>.
5-Cholesten-3β-ol-7-one (7-ketocholesterol) is a cholestanoid that consists of cholesterol bearing an oxo substituent at position 7. 5-Cholesten-3β-ol-7-one has a role as a neuroprotective agent. 5-Cholesten-3β-ol-7-one is a 3beta-sterol, a cholestanoid, a 7-oxo steroid and a 3beta-hydroxy-Delta(5)-steroid.
Norathyriol (Mangiferitin) is a natural metabolite of <i>Mangifera</i>. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM. Norathyriol inhibits <b>PPARα</b>, <b>PPARβ</b>, and <b>PPARγ </b> with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.<