NCX

Inhibitory Selectivity

Isoform-specific Inhibitors

NCX Products

New NCX Products
Catalog No. Information Product Use Citations Product Validations
S4643New

KB-R7943 mesylate

KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCX(rev)) with IC50 of 5.7 μM. KB-R7943 mesylate promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux.

E0002New

CGP-37157

CGP-37157 is a potent, selective, and specific inhibitor of mitochondrial Na(+)-Ca2+ exchanger at concentrations ≤ 10 μM.

S6920New

SEA0400

SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner.

S3558New

Benzamil

Benzamil (Benzylamiloride), an analogue of amiloride, is a Na+/Ca2+ exhanger (NCX) inhibitor with IC50 of ~ 100 nM and an epithelial sodium channel (ENaC) blocker. Benzamil inhibits TRPP3-mediated Ca2+-activated currents with IC50 of 1.1 μM.

S0406

Benzylamiloride hydrochloride

Benzamil hydrochloride is a potent and specific blocker of sodium channel (ENaC).

S0016

SN-6

SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 inhibits NCX1, NCX2, and NCX3 with IC50 of 2.9 μM, 16 μM and 8.6 μM, respectively. SN-6 abolishes acetylcholine (ACh)-induced vasodilation.

Catalog No. Information Product Use Citations Product Validations
S4643New

KB-R7943 mesylate

KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCX(rev)) with IC50 of 5.7 μM. KB-R7943 mesylate promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux.

E0002New

CGP-37157

CGP-37157 is a potent, selective, and specific inhibitor of mitochondrial Na(+)-Ca2+ exchanger at concentrations ≤ 10 μM.

S6920New

SEA0400

SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner.

S3558New

Benzamil

Benzamil (Benzylamiloride), an analogue of amiloride, is a Na+/Ca2+ exhanger (NCX) inhibitor with IC50 of ~ 100 nM and an epithelial sodium channel (ENaC) blocker. Benzamil inhibits TRPP3-mediated Ca2+-activated currents with IC50 of 1.1 μM.

S0406

Benzylamiloride hydrochloride

Benzamil hydrochloride is a potent and specific blocker of sodium channel (ENaC).

S0016

SN-6

SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 inhibits NCX1, NCX2, and NCX3 with IC50 of 2.9 μM, 16 μM and 8.6 μM, respectively. SN-6 abolishes acetylcholine (ACh)-induced vasodilation.