NCX
Inhibitory Selectivity
NCX Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S4643 |
KB-R7943 mesylateKB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCX(rev)) with IC50 of 5.7 μM. KB-R7943 mesylate promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux. |
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| E0002 |
CGP-37157CGP-37157 is a potent, selective, and specific inhibitor of mitochondrial Na(+)-Ca2+ exchanger at concentrations ≤ 10 μM. |
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| S6920 |
SEA0400SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner. |
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| S3558 |
BenzamilBenzamil (Benzylamiloride), an analogue of amiloride, is a Na+/Ca2+ exhanger (NCX) inhibitor with IC50 of ~ 100 nM and an epithelial sodium channel (ENaC) blocker. Benzamil inhibits TRPP3-mediated Ca2+-activated currents with IC50 of 1.1 μM. |
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| S0406 |
Benzylamiloride hydrochlorideBenzamil hydrochloride is a potent and specific blocker of sodium channel (ENaC). |
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| S0016 |
SN-6SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 inhibits NCX1, NCX2, and NCX3 with IC50 of 2.9 μM, 16 μM and 8.6 μM, respectively. SN-6 abolishes acetylcholine (ACh)-induced vasodilation. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S4643 |
KB-R7943 mesylateKB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCX(rev)) with IC50 of 5.7 μM. KB-R7943 mesylate promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux. |
||
| E0002 |
CGP-37157CGP-37157 is a potent, selective, and specific inhibitor of mitochondrial Na(+)-Ca2+ exchanger at concentrations ≤ 10 μM. |
||
| S6920 |
SEA0400SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner. |
||
| S3558 |
BenzamilBenzamil (Benzylamiloride), an analogue of amiloride, is a Na+/Ca2+ exhanger (NCX) inhibitor with IC50 of ~ 100 nM and an epithelial sodium channel (ENaC) blocker. Benzamil inhibits TRPP3-mediated Ca2+-activated currents with IC50 of 1.1 μM. |
||
| S0406 |
Benzylamiloride hydrochlorideBenzamil hydrochloride is a potent and specific blocker of sodium channel (ENaC). |
||
| S0016 |
SN-6SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 inhibits NCX1, NCX2, and NCX3 with IC50 of 2.9 μM, 16 μM and 8.6 μM, respectively. SN-6 abolishes acetylcholine (ACh)-induced vasodilation. |
