New Products

PI3K/Akt/mTOR
Catalog No. Product Name Information Added
S7614 MHY-1685 MHY-1685 is a novel mTOR inhibitor, which attenuates senescence by modulating autophagy through the inhibition of mTOR in human cardiac stem cells. Aug 08 2022
E0798 WAY-119064 WAY-119064 is a potent glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 value of 80.5 nM. Jul 31 2022
S9833 BAY-3827 BAY-3827 is a potent AMPK inhibitor which inhibits AMPK kinase activity with IC50 values of 1.4 nM at a low, 10 μM ATP concentration and 15 nM at a high, 2 mM ATP concentration. Jul 24 2022
E2391 α-Linolenic acid   Jul 20 2022
E2384 (E)-Akt inhibitor-IV (E)-Akt inhibitor-IV is a PI3K-Akt inhibitor, with potent cytotoxic. Jul 17 2022
E0795 COH-SR4 COH-SR4 suppresses adipogenesis in 3T3-L1 cells through indirect activation of AMPK and downstream modulation of the Mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, which blocks important regulators involved in protein synthesis, cell cycle progression, and expression of key transcription factors and their target adipogenic genes involved in lipid synthesis.  Jul 17 2022
E2366 IHMT-PI3Kδ-372 IHMT-PI3Kδ-372 is a potent and selective phosphatidylinositol 3-kinase δ (PI3Kδ) inhibitor with an IC50 of 14 nM in the biochemical assay. Jul 11 2022
P1156 Malantide Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase, which is a highly specific substrate for PKA with a Km of 15 μM. Jul 10 2022
P1154 PKI 14-22 amide,myristoylated PKI 14-22 amide, myristoylated is a potent cAMP-dependent PKA inhibitor, which can reduce the IgG-mediated phagocytic response and also inhibits neutrophil adhesion. Jul 10 2022
P1155 CREBtide CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA substrate. Jul 10 2022
JAK/STAT
Catalog No. Product Name Information Added
E0793 G5-7 G5-7 is an orally active and allosteric JAK2 inhibitor, selectively inhibits JAK2 mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. Jul 11 2022
E2644 Tetramethylcurcumin Tetramethylcurcumin (FLLL31), a small-molecule signal transducer and activator of transcription 3 (STAT3) inhibitor derived from curcumin, binds selectively to Janus kinase 2 and the STAT3 Src homology-2 domain, which serve crucial roles in STAT3 dimerization and signal transduction. Jul 05 2022
E2398 STAT5-IN-2 STAT5-IN-2 inhibits the growth of acute and chronic myeloid leukemia cells and the phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation, with minimal effects on bone marrow stromal cells that play vital functions in the microenvironment of hematopoietic and leukemic cells. Jun 19 2022
S9920 GYY4137 GYY4137 is a novel, water-soluble hydrogen sulfide (H2S)–releasing molecule with vasodilator and antihypertensive activity. GYY4137 shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. GYY4137 also shows anti-inflammatory activity. Oct 26 2021
S6789 JAK Inhibitor I (Pyridone 6) JAK Inhibitor I (Pyridone 6, CMP 6, Compound 6) is a pan-JAK inhibitor with IC50s of 1 nM, 1 nM, 5 nM and 15 nM for JAK2, TYK2, JAK3 and JAK1, respectively. Oct 11 2021
S3566 Cerdulatinib (PRT062070) Cerdulatinib (PRT062070, PRT2070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively, also inhibits19 other tested kinases with IC50 less than 200 nM. Mar 04 2021
S9676 Ropsacitinib (PF-06826647) Ropsacitinib (PF-06826647, Tyk2-IN-8, compound 10) is a selective and orally administered inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 17 nM for binding to TYK2 catalytically active JH1 domain. PF-06826647 (Tyk2-IN-8, compound 10) also inhibits JAK1 and JAK2 with IC50 of 383 nM and 74 nM, respectively. PF-06826647 (Tyk2-IN-8, compound 10) is used in the treatment of psoriasis (PSO). Aug 27 2020
S9664 Colivelin Colivelin (CLN) is a brain-penetrant neuroprotective peptide with potent long-term capacity against deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3. Aug 20 2020
S0918 Ginkgolic acid C17:1 Ginkgolic acid C17:1 (GAC 17:1) inhibits constitutive activation of STAT3 through the abrogation of upstream JAK2 and Src. Ginkgolic acid C17:1 can induce the substantial expression of PTEN and SHP-1. Ginkgolic acid C17:1 induces apoptosis of tumor cells. Jul 26 2020
S0981 BD750 BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell proliferation, respectively. Jul 26 2020
Cell Cycle
Catalog No. Product Name Information Added
S8264 NVS-PAK1-1 NVS-PAK1-1 is a potent and selective allosteric p21-activated kinase 1 (PAK1) inhibitor with an IC50 of 5 nM. Aug 23 2022
E2658 FN-1501 FN-1501 is a potent inhibitor of Fms-like receptor tyrosine kinase 3 (FLT3) and cyclin-dependent kinase (CDK), with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. Jul 28 2022
E2519 WAY-624704 WAY-624704 is a novel Rho kinases (ROCK) inhibitor with an Ki of 17 nM. Jul 19 2022
E2821 RGB-286638 free base RGB-286638 free base is a Cyclin-dependent kinase (CDK) inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM. Jul 11 2022
E2396 STK16-IN-1 STK16-IN-1 is a serine/threonine protein kinase 16 (STK16) inhibitor with an IC50 of 295 nM. Jul 07 2022
E0779 Paprotrain Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM. Jul 04 2022
S1239 TAK-960 TAK-960 is a novel, investigational, orally bioavailable, potent, and selective PLK1 inhibitor that has shown activity in several tumor cell lines, including those that express multidrug-resistant protein 1 (MDR1). Jul 04 2022
E0338 AKI603 AKI-603 is an inhibitor of Aurora kinase A (AurA), which is developed to overcome resistance mediated by BCR-ABL-T315I mutation. Jul 04 2022
E0342 Aurora kinase Inhibitor II Aurora kinase inhibitor II, an anilinoquinazoline that is both a potent and selective ATP-competitive inhibitor of Aurora kinase (ARK), has the ability to permeate the cell and is involved in the regulation of the cell cycle, particularly cell division. Jul 04 2022
E2642 CGP60474 CGP60474, a highly potent anti-endotoxemic agent, is a potent cyclin-dependent kinase (CDK) inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively). Jul 03 2022
DNA Damage
Catalog No. Product Name Information Added
E1277 TH10785 TH10785 controls the catalytic activity mediated by a nitrogen base within molecular structure of cells and increases 8-oxoguanine DNA glycosylase 1 (OGG1) recruitment and repair of oxidative DNA damage. Aug 14 2022
E2849 TH5427 TH5427 is a potent and cell-active NUDT5 (also called NUDIX5) inhibitor that can be used to further understand the role of NUDT5 in biological systems. Aug 01 2022
S6977 DR2313 DR2313 is a potent, selective, competitive and brain-penetrant inhibitor of poly(ADP-ribose) polymerase (PARP), with IC50s of 0.20 μM and 0.24 μM for PARP-1 and PARP-2, respectively.  Jul 17 2022
S9905 SU0268 SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1), with the IC50 of 0.059 μM. Jul 05 2022
P1116 Epitalon Epitalon is an anti-aging agent and a telomerase activator, with an inhibitory effect of the on the development of spontaneous tumors in mice, as well as geroprotective actions and intranasal administration increases neuronal activity, also can be used for cancer, old age and Retinitis Pigmentosa. Jun 23 2022
E2516 Doxorubicin Adriamycin (Doxorubicin, Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent, inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication, and induces apoptosis, also inhibits human DNA topoisomerase I with an IC50 of 0.8 μM. Jun 20 2022
E1136 SKLB-197 SKLB-197 exerts selectively inhibition against ataxia telangiectasia mutated and Rad3-related (ATR) kinase with IC50 of 0.013 μM, also displays potent antitumor activity against ATM-deficent tumors both in vitro and in vivo. Jun 19 2022
E1057 M4076 M4076 inhibits Ataxia telangiectasia-mutated (ATM) kinase activity with a sub-nanomolar potency and shows remarkable selectivity against other protein kinases, suppresses DSB repair, clonogenic cancer cell growth, and potentiates antitumor activity of ionizing radiation in cancer cell lines. Jun 16 2022
E0510 Cidofovir hydrate Cidofovir hydrate is a selective inhibitor of viral DNA synthesis through the selective inhibition of viral DNA polymerase. Jun 16 2022
E1146 CHD1Li 6.11 CHD1Li 6.11, a potent oncogenic chromodomain helicase DNA binding protein 1 like (CHD1L) inhibitor and an orally bioavailable antitumor agent, shows the enzymatic inhibition of the catalytic CHD1L (cat-CHD1L) recombinant protein with IC50 of 3.3 µM, and significantly reduces the tumor volume of colorectal cancer (CRC) xenografts generated from isolated quasi mesenchymal cells (M-Phenotype).  May 16 2022
TGF-beta/smad
Catalog No. Product Name Information Added
P1167 pm26TGF-β1 peptide (TFA) Pm26TGF-β1 peptide TFA is a peptide is a portion of the human TGF-β1 molecule, which shows high affinity for the TGF-β1 receptor. Jul 24 2022
P1164 LSKL, Inhibitor of Thrombospondin (TSP-1) LSKL, Inhibitor of Thrombospondin (TSP-1), a small molecular peptide and competitive antagonist for transforming growth factor-β1 (TGF-β1), protects against subarachnoid fibrosis and hydrocephalus after subarachnoid hemorrhage (SAH). Jul 18 2022
E2394 TGFβRI-IN-3 TGFβRI-IN-3 represents a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology, inhibits TGFβR1 at an IC50 of 0.79 nM with 2000-fold selectivity against MAP4K4. Jul 04 2022
E2368 N-Desmethyltamoxifen hydrochloride N-Desmethyltamoxifen hydrochloride (N-Desmethyl tamoxifen HCl), the primary metabolite of tamoxifen, is an estrogen response modifer and protein kinase C inhibitor with IC50 of 25 µM. Jul 04 2022
P1218 Disitertide(P144) Disitertide (P144) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor, is also a PI3K inhibitor and an apoptosis inducer. Jun 30 2022
E0786 N-Desmethyltamoxifen N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation. Jun 26 2022
E2839 Bisindolylmaleimide VIII (acetate) Bisindolylmaleimide VIII (acetate) (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC, also exerting IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively. Jun 24 2022
S7710 R-268712 R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM. Jun 16 2022
S3552 SIS3 SIS3 is a cell-permeable inhibitor of Smad3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduces TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts. Feb 25 2021
S7692 A-83-01 A-83-01 is a potent inhibitor of TGF-β type I receptor (ALK5-TD) with IC50 of 12 nM. A-83-01 also inhibits the transcription induced by activin/nodal type I receptor (ALK4-TD) and nodal type I receptor (ALK7-TD) with IC50 of 45 nM and 7.5 nM, respectively.Solutions are best fresh-prepared. Jun 03 2020
GPCR & G Protein
Catalog No. Product Name Information Added
E1247 SR95531 Gabazine(SR95531) is a potent competitive and allosteric antagonist of the GABAA receptor, with an IC50 for the GABA receptor of 9 µM. Sep 01 2022
S3451 PH-064 PH-064 (BIM-46187) is a novel imidazo-pyrazine derivative that inhibits the heterotrimeric G-protein complex effectively. PH-064 (BIM46174) inhibits heterotrimeric G-protein signalling in GPCRsthat mediate cyclic AMP generation (GAs), calcium release (GAq), cancer cell invasion by Wnt-2 frizzled receptors, and high-affinity neurotensin receptors (GAo/i and GAq). Aug 28 2022
E2660 Pamoic acid disodium Pamoic acid disodium, a potent GPR35 agonist with an EC50 value of 79 nM, induces GPR35a internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively, also potently recruits β-arrestin2 to GPR35 showing an antinociceptive effect. Aug 04 2022
P1153 PKG inhibitor peptide PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM. Aug 02 2022
E2646 HA-100 HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase. Jul 28 2022
S9916 SCH79797 dihydrochloride SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist, which can inhibit binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM. Jul 28 2022
E2506 A-3 hydrochloride A-3 hydrochloride, a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases, againsts cAMP-dependent protein kinase (PKA) (Ki=4.3 µM), casein kinase II (CK2) (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM), also inhibits Protein Kinase C (PKC) and casein kinase I (CK1) with Ki values of 47 µM and 80 µM, respectively. Jul 26 2022
P1110 Etelcalcetide HCl Etelcalcetide HCl (AMG 416) is a novel synthetic peptide agonist of the calcium-sensing receptor (CaSR) composed of a linear chain of seven d-amino acids with a d-cysteine linked to an l-cysteine via a disulfide bond. Jul 20 2022
E0799 VU 0365114 VU 0365114 is a muscarinic acetylcholine receptor M5-preferring (mAChR M5-preferring) positive allosteric modulator (PAM) with an EC50 of 2.7 μM. Jul 17 2022
E1158 CAY10444 CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist, which can inhibit S1P response of S1P3 cell line with 78% inhibition rate and IC50 of 4.6 μM. Jul 07 2022
PTK
Catalog No. Product Name Information Added
E2853 GSK626616 GSK-626616 is a dual-specificity tyrosine-regulated kinase (DYRK3) inhibitor with an IC50 of 0.7 nM which is a potential therapy for the treatment of anemia. Aug 29 2022
S5248 Apatinib Apatinib (Rivoceranib, YN968D1) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib induces both autophagy and apoptosis. Aug 12 2022
S2221 Apatinib (YN968D1) mesylate Apatinib mesylate (YN968D1, Rivoceranib) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib mesylate induces both autophagy and apoptosis. Aug 12 2022
E2399 Falnidamol Falnidamol (BIBX1382) is a selective inhibitor of epidermal growth factor receptor (EGFR), exerting anti-cancer role in human head and neck squamous cell carcinomas both in vitro and in vivo through suppressing mitogen-activated protein kinases (MAPKs) signaling. Jul 31 2022
E2202 1-Naphthyl PP1 hydrochloride 1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of Src family kinases, inhibits v-Src, c-Fyn, c-Abl, CDK2 and CAMKII with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively. Jul 26 2022
E2655 Terevalefim Terevalefim (ANG-3777), a small molecule hepatocyte growth factor (HGF) mimetic, induces c-MET dimerization and phosphorylation, reducing apoptosis and increasing cellular proliferation. Jul 21 2022
P1152 Oglufanide Oglufanide (H-Glu-Trp-OH, L-Glutamyl-L-tryptophan), a dipeptide immunomodulator isolated from calf thymus, inhibits vascular endothelial growth factor (VEGF), also stimulates the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Jul 18 2022
E2390 Thalidomide-5-NH2-CH2-COOH Thalidomide-5-NH2-CH2-COOH is a potent and selective inhibitor of tropomyosin receptor kinase (Trk). Jul 07 2022
E0340 CSF1R-IN-1 CSF1R-IN-1 is a CSF1R (Colony Stimulating Factor 1 Receptor) inhibitor with an IC50 of 0.5 nM in vitro kinase activity assay. Jul 04 2022
E0344 ErbB2 inhibitor ErbB-2 Inhibitor is a EGFR, ErbB2 and ErbB4 inhibitor with IC50s of 0.017 μM, 0.08 μM, 1.91 μM. Jul 04 2022
Epigenetics
Catalog No. Product Name Information Added
S9683 GSK778 GSK778 (iBET-BD1) is a strong BD1 bromodomain inhibitor of the BET proteins, with IC50 value of 75 nM for BRD2 BD1, 41 nM for BRD3 BD1, 41 nM for BRD4 BD1, and 143 nM for BRDT BD1. Sep 01 2022
E0068 NiCur NiCur is a small molecule which blocks CREB-binding protein (CBP) histone acetyltransferase (HAT) activity and downregulates p53 activation upon genotoxic stress and diminishs the recruitment of p53 as well as RNA Polymerase II and levels of acetylation on histone H3 on CDKN1A promoter. Jul 17 2022
S6397 Thalidomide-NH-C4-NH-Boc Thalidomide-NH-C4-NH-Boc is a novel, potent, and selective class of Bromodomain-containing protein 4 (BRD4) and Bromodomain-containing protein 2 (BRD2) degrader for the development of therapeutics to treat cancers. Jul 17 2022
E0781 BAZ1A-IN-1 BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein), exerting a Kd value of 0.52 μM against BAZ1A bromodomain, shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A. Jun 26 2022
E0394 YK 3-237 YK-3-237, a SIRT1 activator, reduces acetylation of mutant p53 and inhibits the proliferation of triple-negative breast cancer cells. Jun 20 2022
E1195 HDAC10-IN-2 HDAC10-IN-1 (13b), a nanomolar inhibitors of HDAC10 with high specificity, inhibits HDAC10 with high specificity over HDAC6 and with no significant impact on class I HDACs, with a IC50 of 58 nM on danio rerio HDAC10 (drHDAC10). Jun 16 2022
E1144 dBRD9 dBRD9 is a bifunctional molecule that links a small molecule that specifically binds to the bromodomain of BRD9 and another ligand that recruits the cereblon E3 ubiquitin ligase, potently and selectively degrades BRD9 with IC50 of 104 nM in MOLM-13 cells. Jun 16 2022
E1024 MRTX1719 MRTX1719 is a potent, selective inhibitor of the protein arginine methyltransferase 5·methylthioadenosine phosphorylase complex (PRMT5•MTA), a potentially tumor-selective target for therapeutic intervention. Jun 16 2022
S9934 KA2507 KA2507, a potent, orally active and selective HDAC6 inhibitor with IC50 of 2.5 nM, shows antitumor activities and immune modulatory effects in preclinical models. Jun 16 2022
S6835 3-deazaadenosine 3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM, and has anti-inflammatory, anti-proliferative and anti-HIV activity. Jun 14 2022
NF-κB
Catalog No. Product Name Information Added
E2661 Chitosan oligosaccharide Chitosan oligosaccharide (COS) is an oligomer of β-(1➔4)-linked d-glucosamine, of which actions involve the modulation of several important pathways including the suppression of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) and the activation of AMP-activated protein kinase (AMPK). Aug 04 2022
E0944 IMD-0560 IMD-0560 is an Inhibitor of nuclear factor kappa-B kinase (IKK) which can suppress the production of inflammatory cytokines and chemokines. Jul 24 2022
E0796 NF-κB-IN-1 NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor, which acts by directly inhibiting inhibitory κB kinase (IKK). Jul 17 2022
E0812 CXD101 CXD101 (HDAC-IN-4) is a potent, selective and orally active class I histone deacetylase (HDAC) inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively. Jul 11 2022
E0783 SM-7368 SM-7368 is a potent NF-κB inhibitor that targets downstream of MAPK p38 activation, also inhibits TNF-α-induced MMP-9 upregulation. Jun 26 2022
S5899 (R)-(-)-Ibuprofen (R)-(-)-Ibuprofen ((R)-Ibuprofen) inhibits the activation of NF-κB in response to T-cell stimulation with IC50 of 121.8 μM, and exerts anti-inflammatory and antinociceptive effects. May 06 2021
S4611 TCEP Hydrochloride TCEP (Tris(2-carboxyethyl)phosphine) hydrochloride, a non-thiol reducing agent, promotes NF-κB-DNA binding in a dose-related manner. Apr 07 2021
S3384 (E/Z)-IT-603 (E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603. IT-603 is a NF-κB family member c-Rel inhibitor with an IC50 of 3 μM in electrophoretic mobility shift assay (EMSA). Dec 11 2020
S1321 Urolithin B Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα. Urolithin B suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass. Nov 18 2020
S0844 NDMC101 NDMC101 inhibits osteoclastogenesis which also ameliorates paw swelling and inflammatory bone destruction, associating with the inhibition of such transcription factors as NF-κB and NFATc1 as well as multiple protein kinases, including p38, ERK, and JNK. Aug 20 2020
Metabolism
Catalog No. Product Name Information Added
E1223 RGX-202 RGX-202 is an SLC6A8 transporter inhibitor which suppress the colon cancer tumor. In addition to significantly reducing intracellular phosphocreatine and ATP levels and inducing tumour apoptosis, RGX-202 also inhibits creatine import both in vitro and in vivo. Sep 01 2022
E0742 Melengestrol Acetate Melengestrol Acetate, progestational steroid suppress the AT3 tumour. Aug 29 2022
E1211 MTB-9655 MTB-9655 is a novel, potent and selective Acetyl-Coenzyme A Synthetase 2 (ACSS2) inhibitor, which is currently in Phase I clinical investigation on patients with tumors with high levels of ACSS2. Aug 24 2022
E1252 MitoPQ MitoPQ (MitoParaquat), a mitochondria-targeted redox cycler, enables the selective generation of superoxide within mitochondria and is a useful tool to investigate the many roles of mitochondrial superoxide in pathology and redox signaling in cells and in vivo. Aug 23 2022
E1149 BAY-179 BAY-179 is an excellent in vivo suitable tool with which to probe the biological relevance of complex I inhibition in cancer indications. Aug 17 2022
S7894 Tunicamycin Tunicamycin, an antibiotic, can potently inhibit the N-linked glycosylation (NLG) by competitively inhibiting UDP-GlcNAc-dolichol-phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) activity and can target several types of tumors by reducing angiogenesis, inhibiting colony formation, and enhancing TRAIL-induced apoptosis. Aug 14 2022
E0941 K-604 dihydrochloride K-604 dihydrochloride, a potent and selective inhibitor of Acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1), suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels. Aug 14 2022
E1208 NPX800 NPX800 is a potent heat shock factor 1 (HSF1) inhibitor, which has the potential for cancer research. Aug 11 2022
E1205 BAY 2666605 BAY 2666605 is an orally active phosphodiesterase 3A (PDE3A) and phosphodiesterase 3B (PDE3B) inhibitor with IC50s of 87 nM and 50 nM, respectively. Aug 07 2022
E2692 L-Ascorbic acid 2-phosphate sesquimagnesium salt L-Ascorbic acid 2-phosphate sesquimagnesium salt (2-Phospho-L-ascorbic acid magnesium), a long-acting vitamin C derivative that can stimulate collagen formation and expression, can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs), which increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation. Aug 04 2022
Proteases
Catalog No. Product Name Information Added
E2365 Glutaminase C-IN-1 Glutaminase C-IN-1 is an allosteric inhibitor of Glutaminase C (GAC) that inhibits cancer cell growth without affecting their normal cellular counterparts. Jul 31 2022
E0079 Compound W Compound W (3,5-Bis(4-nitrophenoxy)benzoic acid) is a 3,3'-diiodothyronine sulfate (3,3'-T2S) cross-reactive material in maternal serum, which can inhibit γ-secretase. Jul 17 2022
S8998 IACS-6274 IACS-6274 (IPN60090), is a potent, selective and orally active glutaminase inhibitor with potential antineoplastic and immunostimulating activities. Jun 23 2022
P1134 diprotin A Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV). Jun 22 2022
E0097 Mericitabine Mericitabine (RG 7128, R-7128, PSI 6130 diisobutyrate) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication. Jun 17 2022
E1014 Upamostat (WX-671) Upamostat (WX-671), a novel serine protease urokinase (uPA) inhibitor by inhibiting the urokinase-type plasminogen activator (uPA) system. Mar 17 2022
E0134 L-Albizziin

L-albizziin (L-alpha-amino-beta-ureidopropionic acid) is a potent inhibitor of glutamase. L-albizziin interferes with the utilisation of L-glutamine by the Debaryomyces spp. enzyme probably in a competitive and reversible manner since L-albizziin is also a substrate of the enzyme.

Nov 18 2021
E0122 Gemigliptin

Gemigliptin (Zemiglo, LC15-0444) is a potent, selective and long-acting dipeptidyl peptidase 4 (DPP 4) inhibitor with a Ki of 7.25 nM. Gemigliptin shows at least >23,000-fold selectivity for DPP-4 over various proteases and peptidases, including DPP-8, DPP-9, and fibroblast activation protein (FAP)-α.

Sep 27 2021
S9896 JNJ-67856633

JNJ-67856633 (JNJ-6633) is a potent, selective, allosteric inhibitor of MALT1 protease.

Sep 23 2021
S9909 ARP 100 ARP 100 (MMP-2 Inhibitor III, Compound 10a) is a potent and selective inhibitor of MMP-2 with an IC50 of 12 nM and displays less inhibitory activity at MMP-9, MMP-3, MMP-1 and MMP-7 with IC50s of 200 nM, 4500 nM, >50,000 nM and >50,000 nM respectively. Sep 01 2021
Microbiology
Catalog No. Product Name Information Added
E1243 Azvudine Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Aug 24 2022
S4592 Captisol (SBE-β-CD) Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) is a novel, chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs. Aug 08 2022
S0081 DDD107498 DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite. Aug 08 2022
E0943 NBD-556 NBD-556 is a novel human immunodeficiency virus type 1 (HIV-1) entry inhibitor that block the gp120-CD4 interaction. Jul 24 2022
E2137 WAY-297407 WAY-297407 is a bioactive compound licensed by Pfizer. Jul 24 2022
E0942 BVDV IN-1 BVDV IN-1 is a non-nucleoside inhibitor of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. Jul 24 2022
E0797 WAY-383487 WAY-383487 is one of the Tat peptide derivatives and inhibits HIV-1 long terminal repeat-activated transcription. Jul 17 2022
S6458 Isavuconazonium sulfate Isavuconazonium sulfate (BAL8557-002), the prodrug of the active triazole Isavuconazole, is an orally active antifungal agent, using for invasive aspergillosis and mucormycosis. Jul 06 2022
E0336 CBS1117 CBS1117 is a virus entry inhibitor with an IC50 of 70 nM for influenza A virus, A/Puerto Rico/8/34 (H1N1), also interferes with the hemagglutinin (HA)-mediated fusion process. Jul 04 2022
E0525 Colistin Colistin(Polymyxin E), a cyclic polypeptide antibiotic synthesized by Bacillus polymyxa subspecies colistinus Koyama, exerts antimicrobial activity by targeting at the bacterial cell membrane. Jun 26 2022
Apoptosis
Catalog No. Product Name Information Added
E1232 Concanavalin A Concanavalin A is a potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics. Aug 25 2022
E2648 RIPK1-IN-7 RIPK1-IN-7 is a potent and selective receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. Jul 31 2022
E2379 ASK1-IN-2 ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. Jul 07 2022
E2631 Colcemid Colcemid (Demecolcine), a derivative of colchicine, is a potent mitotic inhibitor which can incuces cell apoptosis and can be used for cancer research. Jul 03 2022
E2822 GSK2983559 active metabolite GSK2983559 active metabolite is an active metabolite of GSK2983559, also is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1. Jun 29 2022
S9970 APG-2575 (lisaftoclax) APG-2575 (lisaftoclax) is a dual Bcl-2 and Bcl-xl inhibitor with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Jun 27 2022
S9736 ME-344 ME-344 directly targets the OXPHOS complex 1, a pathway involved in the production of ATP, in the mitochondria. Treatment of tumor cells with ME-344 as a single agent results in a rapid loss of ATP and cancer cell death.ME-344 results in inhibition of cell growth and viability in all the leukemia cell lines with IC50 values in the range of 70–260 nM. Jun 16 2022
E1139 DX3-213B DX3-213B is a highly potent, orally active oxidative phosphorylation (OXPHOS) complex I inhibitor with IC50 of 3.6 nM, and impairs ATP generation with IC50 of 11 nM. Jun 16 2022
E2028 Humanin (human) Humanin (human) (1-24-Protein humanin (human)), a small mitochondrial-derived cytoprotective polypeptide encoded by mtDNA, exhibits protective effects in several cell types against cellular stress conditions and apoptosis through regulating various signaling mechanisms, such as JAK/STAT pathway and interaction of BCL-2 family of protein. Apr 01 2022
S7274 HLY78 HLY78 inhibits apoptosis in tumor cells and embryonic cells caused by carbon ion radiation through activation of the Wnt/β-catenin pathway. Mar 17 2022
MAPK
Catalog No. Product Name Information Added
E0946 MAP4K4-IN-3 MAP4K4-IN-3 is a potent and selective Mitogen-activated protein kinase 4 (MAP4K4) inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Aug 17 2022
S0388 SD169 SD-169(5-Carbamoylindole) is a selective inhibitor of p38α MAPK, which can reduce p38 and HSP60 expression in T cells of the pancreatic beta islets. Aug 01 2022
E0934 Raf inhibitor 2 Raf inhibitor 2 is a potent Raf kinase inhibitor with an IC50 of <1.0 μM. Aug 01 2022
E0114 Dilmapimod (SB-681323) Dilmapimod (SB-681323,GW 681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease. Jul 21 2022
E2252 SU3327 SU3327 is a potent, selective and substrate-competitive c-Jun N-terminal kinase (JNK) inhibitor with an IC50 of 0.7 μM. Jul 11 2022
E2203 DMU-212 DMU-212 is a methylated derivative of Resveratrol, with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities, which can induce mitotic arrest via induction of apoptosis and activation of extracellular-signal-regulated kinase1/2 (ERK1/2) protein. Jul 11 2022
E2651 Raf inhibitor 1 Raf inhibitor 1 is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-Raf WT, B-Raf V600E, and C-Raf, respectively. Jul 07 2022
S6641 GW284543 (UNC10225170) GW284543 (UNC10225170), a MEK5-selective inhibitor, inhibits MEK5 in a dose-dependently way as determined by reductions in pERK5, and decreases endogenous MYC protein. Jul 05 2022
S0739 PD184161 PD184161, an orally active MEK inhibitor with IC50 of 10-100 nM in a time- and concentration-dependent manner, inhibits cell proliferation and induces apoptosis, and produces depressive-like behavior. Jun 20 2022
E0526 sappanone A Sappanone A, a homoisoflavanone isolated from the heartwood of Caesalpinia sappan (Leguminosae), induces HO-1 expression by activating Nrf2 through the p38 MAPK pathway, suppresses LPS-induced NF-κB activation by suppressing the phosphorylation of RelA/p65 at Ser536, exerting its anti-inflammatory effect. Jun 20 2022
Angiogenesis
Catalog No. Product Name Information Added
E1191 GDC-1971   Sep 26 2022
E1244 FINO2   Sep 25 2022
E1259 DNQX   Sep 25 2022
E2807 WAY-641966   Sep 05 2022
E2805 WAY-320461   Sep 05 2022
E2851 Trastuzumab Emtansine(T-DM1) Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1. Aug 08 2022
E2643 TL02-59 TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC50 of 0.03 nM. Jul 31 2022
E2201 N-piperidine Ibrutinib hydrochloride N-piperidine Ibrutinib hydrochloride, a reversible Ibrutinib derivative, is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively. Jul 25 2022
E2168 PHD-1-IN-1 PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC50 of 0.034 μM Jul 24 2022
E0534 WAY-340935 WAY-340935 (VEGFR2-IN-2) can inhibit the function of VEGFR2 and the anti-proliferative activity against the H460 cell line is produced partly by interaction of VEGFR protein. Jul 20 2022
Stem Cell & Wnt
Catalog No. Product Name Information Added
E0787 ALLO-2 ALLO-2 is potent antagonist of both wild-type mouse Smo and drug-resistant D473H mutant human Smo that inhibits Smo agonist inhibited Gli-Luc activity in TM3-Gli-Luc cells with IC50 of 6 nM. Jul 18 2022
P1216 Box5 Box5, a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist, inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells, antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2+) signaling. Jul 04 2022
S9965 M435-1279 M435-1279 is a UBE2T inhibitor, inhibiting the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1. Jun 30 2022
E0480 MRT-81 MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells, exerting potent hedgehog (Hh) signaling pathway inhibiting activity. Jun 20 2022
E0782 MRT 10 MRT-10 inhibits ShhN signaling in Shh-light2 cells in a dose-dependent manner with IC50 of 0.64 μM, showing the capacity to abrogate the constitutive activity of Smo. Jun 20 2022
S6699 Gigantol Gigantol is a bibenzyl component isolated from several medicinal orchids, which can inhibit Wnt/β-catenin pathway and has anti-tumor activity. Apr 06 2022
S6384 Smoothened Agonist (SAG)

Smoothened Agonist (SAG) is potent agonist of Smoothened (Smo). Smoothened Agonist induces firefly luciferase expression in Shh-LIGHT2 cells with an EC50 of 3 nM.

Nov 04 2021
E0033 IWP-4

IWP-4 is a potent Wnt/β-catenin signaling pathway inhibitor with an IC50 of 25 nM.

Sep 01 2021
S5992 Heparan Sulfate Heparan sulfate (HS, Heparitin sulfate, Alpha-idosane, HHS 5, N-Acetylheparan Sulfate, Suleparoid, Tavidan), a constituent of HS proteoglycans (HSPGs), is a linear polysaccharide present on the cell surface. Heparan sulfate influences the binding affinity of intestinal epithelium cells (IECs) to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury. May 17 2021
S9828 WAY-262611 WAY-262611 (BML-WN110, Compound 5) is a beta-catenin (β-Catenin) agonist that increases bone formation rate with EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also an inhibitor of dickkopf 1 (DKK1). May 06 2021
Ubiquitin
Catalog No. Product Name Information Added
E0947 Iu1-248 Iu1-248, a derivative of IU1, is a potent and selective ubiquitin specific peptidase 14 (USP14) inhibitor with an IC50 of 0.83 μM. Jul 21 2022
E1118 SJB3-019A SJB3-019A, a potent USP1 inhibitor, is 5 times more potent than SJB2-043 in promoting inhibitor of DNA-binding-1 (ID1) degradation and cytoxicity with IC50 of 0.0781 μM in K562 cells. Jun 16 2022
E0389 DUBs-IN-2 DUBs-IN-2 is a potent inhibitor of USP7 and USP8 deubiquitinating enzymes.  May 06 2022
E1087 5-amino-2,4-dimethylpyridine (5A-DMP)

5-amino-2,4-dimethylpyridine (5A-DMP) is a novel tandem Tudor domain (TTD)-binding compound that inhibits the full-length UHRF1:LIG1 interaction in Xenopus egg extracts.

Jan 24 2022
E0351 NSC232003 NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor that binds to the 5mC binding pocket of the SRA domain of UHRF1. NSC232003 modulates DNA methylation in a cellular context. Dec 22 2021
S6943 IU1-47 IU1-47 is a potent and specific inhibitor of USP14 with an IC50 of 0.6 μM. IU1-47 shows ∼33-fold selectivity for USP14 over USP5 (IsoT). Sep 10 2021
S8300 CC-885

CC-885 is a novel cereblon (CRBN) modulator. CC-885 selectively promotes CRBN- and p97-dependent PLK1 ubiquitination and degradation.

Sep 01 2021
S9832 CC-90009 CC-90009 is a novel cereblon (CRBN) E3 ligase modulator and specifically targets GSPT1 (G1 to S phase transition 1) for proteasomal degradation. Aug 19 2021
S6883 HBX 19818 HBX19818 is a specific inhibitor of USP7 with an IC 50 of 28.1 μM. Jul 23 2021
S8967 XL177A XL177A is a potent, selective and irreversible inhibitor of Ubiquitin specific peptidase 7 (USP7) with IC50 of 0.34 nM. May 24 2021
Neuronal Signaling
Catalog No. Product Name Information Added
E2684 Icilin Icilin is an agonist of the transient receptor potential M8 (TRPM8) ion channel with an EC50 of 1.4 μM. Aug 02 2022
P1165 Pep2m, myristoylated (TFA) Pep2m, myristoylated (TFA) is a cell-permeable peptide, which can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. Jul 28 2022
E0777 Z944 Z944 is a highly selective antagonist for T-type calcium channel with IC50s of 50, 160, 110 nM for hCaV3.1, hCaV3.2, and hCaV3.3. Jul 24 2022
E0535 WAY-303290 WAY-303290 (GluR6 antagonist-1) is a benzothiophene derivative acting as an ionotropic glutamate receptor 6 (GluR6) antagonist, which can be used for researching acute and chronic neurological disorders. Jul 21 2022
E1265 Deschloroclozapine Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs (muscarinic Designer Receptors Exclusively Activated by Designer Drugs) agonist, and binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. Jul 20 2022
E0070 4F 4PP oxalate 4F 4PP oxalate is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 5.3 nM), which is selective for 5-HT2A receptors over 5-HT1C receptors (Ki = 620 nM).  Jul 17 2022
E0829 Nitrocaramiphen hydrochloride Nitrocaramiphen hydrochloride is an antagonist of muscarinic acetylcholine receptor M1 (mAChR M1), which can completely remove the hyperpolarizing effect of muscarine. Jul 11 2022
E2515 JT010 JT010 is a potent agonist of transient receptor potential cation channel subfamily A member 1 (TRPA1) with an EC50 of 0.65 nM. Jul 11 2022
S3535 Deudextromethorphan (AVP-786) Deudextromethorphan (AVP-786), an orally administered compound formed by combining deuterated (d6)-dextromethorphan hydrobromide (to reduce first-pass metabolism) and ultra-low-dose quinidine sulfate, is an active N-methyl-D-aspartate (NMDA) receptor antagonist. Jul 04 2022
E1128 BzATP triethylammonium salt BzATP triethylammonium salt acts as a P2X receptor agonist with pEC50s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively, also is potent at P2X7 receptors with EC50s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively. Jul 03 2022
Others
Catalog No. Product Name Information Added
E2852 BC-1471 BC-1471, a small-molecule inhibitor of STAM-binding protein (STAMBP) deubiquitinase activity, decreases NACHT, LRR and PYD domains-containing protein 7 (NALP7) protein levels and suppresses IL-1β release after TLR agonism. Aug 28 2022
E1292 4-Thiouridine 4-thiouridine (4-Thio-UTP), a thiouridine and a nucleoside analogue, has a role as an affinity label and an antimetabolite. Aug 22 2022
E2694 D-Saccharic acid 1,4-lactone monohydrate D-Saccharic acid 1,4-lactone monohydrate is a potent β-glucuronidase inhibitor with an IC50 of 48.4 μM. Aug 22 2022
E1245 Ro5-3335 Ro5-3335 is an inhibitor of Core binding factor leukemia (CBF leukemia), by interacting with RUNX1 and CBFβ directly, repressing RUNX1/CBFB-dependent transactivation and runx1-dependent hematopoiesis. Aug 17 2022
E2695 FITC-Dextran (MW 10000) FITC-Dextran(MW 10000) are polysaccharides comprised of varying lengths of branched glucose molecules and can be used to determine solute, ion and protein permeability of the blood-brain barrier (BBB) based on the size of the dextran used. Aug 17 2022
E1277 TH10785 TH10785 controls the catalytic activity mediated by a nitrogen base within molecular structure of cells and increases 8-oxoguanine DNA glycosylase 1 (OGG1) recruitment and repair of oxidative DNA damage. Aug 14 2022
E1275 FR054 FR054 is a novel inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3 with a remarkable anti-breast cancer effect. Aug 14 2022
S8936 VBIT-12 VBIT-12 is a potent inhibitor of Voltage-dependent anion-selective channel 1 (VDAC1), directly interacting with purified VDAC1, reducing its channel conductance and preventing VDAC1 oligomerization. Aug 08 2022
S0352 NLX-204 NLX-204 is a potent, selective agonist of ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor with pKi of 10.19. Aug 08 2022
S3544 VBIT-4 VBIT-4 is a voltage-dependent anion channel (VDAC) oligomerization inhibitor that decreases mitochondrial DNA (mtDNA) release, type I interferon (IFN) signaling, neutrophil extracellular traps, and disease severity in a mouse model of systemic lupus erythematosus. Aug 08 2022