p97

Inhibitory Selectivity

p97 Products

All (3) p97 Inhibitors (3) New p97 Products

Catalog No.	Information	Product Use Citations	Product Validations
S7285	NMS-873 NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).	Nat Chem Biol, 2021, 10.1038/s41589-020-00726-x Nature, 2020, 578(7794):296-300 Nature, 2020, 578(7794):296-300	(E) The mDPC level induced by HN2 in the presence of MG132 or NMS-873. MG132 or NMS-873 were added for 3 h after HN2 exposure and then replaced by normal medium until 24 h.
S7199	DBeQ DBeQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.	Nat Chem Biol, 2021, 10.1038/s41589-020-00726-x J Virol, 2020, JVI.01570-20 Cell, 2019, 177(3):766-781
S4453^New	NPD8733 NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration that specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family.

Catalog No.

Information

Product Use Citations

Product Validations

S7285

NMS-873

NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).

Nat Chem Biol, 2021, 10.1038/s41589-020-00726-x

Nature, 2020, 578(7794):296-300

S7199

DBeQ

DBeQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.

Nat Chem Biol, 2021, 10.1038/s41589-020-00726-x

J Virol, 2020, JVI.01570-20

Cell, 2019, 177(3):766-781

S4453^New

NPD8733

NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration that specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family.

Catalog No.	Information	Product Use Citations	Product Validations
S7285	NMS-873 NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).	Nat Chem Biol, 2021, 10.1038/s41589-020-00726-x Nature, 2020, 578(7794):296-300 Nature, 2020, 578(7794):296-300	(E) The mDPC level induced by HN2 in the presence of MG132 or NMS-873. MG132 or NMS-873 were added for 3 h after HN2 exposure and then replaced by normal medium until 24 h.
S7199	DBeQ DBeQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.	Nat Chem Biol, 2021, 10.1038/s41589-020-00726-x J Virol, 2020, JVI.01570-20 Cell, 2019, 177(3):766-781
S4453^New	NPD8733 NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration that specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family.

Catalog No.

Information

Product Use Citations

Product Validations

S7285