ISRIB (trans-isomer)

Catalog No.S7400

ISRIB (trans-isomer) Chemical Structure

Molecular Weight(MW): 451.34

ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM and does not have global effects on translation, transcription, or mRNA stability in non-stressed cells.

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Cited by 5 Publications

1 Customer Review

  • PERK inhibitor treatment restores female development in zar1 homozygous mutants. Juveniles were treated with two PERK inhibitors from 22 dpf to 60 dpf. Final concentration: ISRIB, 50 nM. **P<0.01, ***P<0.001.

    Development, 2017, 144(1):128-138. ISRIB (trans-isomer) purchased from Selleck.

Purity & Quality Control

Choose Selective PERK Inhibitors

Solubility (25°C)

In vitro DMSO 4 mg/mL (8.86 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 451.34
Formula
C22H24Cl2N2O4
 
 
CAS No. 1597403-47-8
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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