RUNX

Inhibitory Selectivity

Isoform-specific Inhibitors

RUNX Products

New RUNX Products
Catalog No. Information Product Use Citations Product Validations
S0790

CADD522

CADD522 is a potent inhibitor of RUNX2(runt-related transcription factor-2)-DNA binding with IC50 of 10 nM. CADD522 exhibits anticancer activity.

S8756

XRK3F2

XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.

S3223

L-Quebrachitol

L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.

S9709

Muramyl dipeptide

Muramyl dipeptide (MDP) is a shared structural unit of peptidoglycans. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2.

E2692New

L-Ascorbic acid 2-phosphate sesquimagnesium salt

L-Ascorbic acid 2-phosphate sesquimagnesium salt (2-Phospho-L-ascorbic acid magnesium), a long-acting vitamin C derivative that can stimulate collagen formation and expression, can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs), which increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.

E3199New

Petasites Japonicus Extract

Petasites Japonicus Extract regulates osteoblast differentiation at least in part through Runt-related transcriptional factor 2 (RUNX2) and Osterix, suggesting an aqueous extract of P. japonicus leaves is likely to be useful as an alternative therapeutic for preventing and treating osteoporosis.

Catalog No. Information Product Use Citations Product Validations
S0790

CADD522

CADD522 is a potent inhibitor of RUNX2(runt-related transcription factor-2)-DNA binding with IC50 of 10 nM. CADD522 exhibits anticancer activity.

S8756

XRK3F2

XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.

Catalog No. Information Product Use Citations Product Validations
S3223

L-Quebrachitol

L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.

S9709

Muramyl dipeptide

Muramyl dipeptide (MDP) is a shared structural unit of peptidoglycans. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2.

E2692New

L-Ascorbic acid 2-phosphate sesquimagnesium salt

L-Ascorbic acid 2-phosphate sesquimagnesium salt (2-Phospho-L-ascorbic acid magnesium), a long-acting vitamin C derivative that can stimulate collagen formation and expression, can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs), which increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.

Catalog No. Information Product Use Citations Product Validations
E3199New

Petasites Japonicus Extract

Petasites Japonicus Extract regulates osteoblast differentiation at least in part through Runt-related transcriptional factor 2 (RUNX2) and Osterix, suggesting an aqueous extract of P. japonicus leaves is likely to be useful as an alternative therapeutic for preventing and treating osteoporosis.