RUNX
Inhibitory Selectivity
Isoform-specific Inhibitors
RUNX Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S0790 |
CADD522CADD522 is a potent inhibitor of RUNX2(runt-related transcription factor-2)-DNA binding with IC50 of 10 nM. CADD522 exhibits anticancer activity. |
||
| S8756 |
XRK3F2XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo. |
||
| S3223 |
L-QuebrachitolL-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level. |
||
| S9709 |
Muramyl dipeptideMuramyl dipeptide (MDP) is a shared structural unit of peptidoglycans. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2. |
||
| E2692New |
L-Ascorbic acid 2-phosphate sesquimagnesium saltL-Ascorbic acid 2-phosphate sesquimagnesium salt (2-Phospho-L-ascorbic acid magnesium), a long-acting vitamin C derivative that can stimulate collagen formation and expression, can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs), which increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation. |
||
| E3199New |
Petasites Japonicus ExtractPetasites Japonicus Extract regulates osteoblast differentiation at least in part through Runt-related transcriptional factor 2 (RUNX2) and Osterix, suggesting an aqueous extract of P. japonicus leaves is likely to be useful as an alternative therapeutic for preventing and treating osteoporosis. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S0790 |
CADD522CADD522 is a potent inhibitor of RUNX2(runt-related transcription factor-2)-DNA binding with IC50 of 10 nM. CADD522 exhibits anticancer activity. |
||
| S8756 |
XRK3F2XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S3223 |
L-QuebrachitolL-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level. |
||
| S9709 |
Muramyl dipeptideMuramyl dipeptide (MDP) is a shared structural unit of peptidoglycans. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2. |
||
| E2692New |
L-Ascorbic acid 2-phosphate sesquimagnesium saltL-Ascorbic acid 2-phosphate sesquimagnesium salt (2-Phospho-L-ascorbic acid magnesium), a long-acting vitamin C derivative that can stimulate collagen formation and expression, can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs), which increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| E3199New |
Petasites Japonicus ExtractPetasites Japonicus Extract regulates osteoblast differentiation at least in part through Runt-related transcriptional factor 2 (RUNX2) and Osterix, suggesting an aqueous extract of P. japonicus leaves is likely to be useful as an alternative therapeutic for preventing and treating osteoporosis. |
