Thymidylate Synthase

Inhibitory Selectivity

Thymidylate Synthase Products

All (3) Thymidylate Synthase Inhibitors (3) New Thymidylate Synthase Products

Catalog No.	Information	Product Use Citations
S5790^New	Folinic acid Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).
S5971^New	Pemetrexed Pemetrexed (LY231514, Alimta) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Br J Cancer, 2021, 10.1038/s41416-021-01441-7 Front Oncol, 2021, 11:668798 Biochem Pharmacol, 2021, 190:114642
S3169^New	2'-Deoxyuridine 5'-monophosphate disodium salt 2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.

Catalog No.

Information

Product Use Citations

Product Validations

S5790^New

Folinic acid

Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).

S5971^New

Pemetrexed (LY231514, Alimta) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.

Br J Cancer, 2021, 10.1038/s41416-021-01441-7

Front Oncol, 2021, 11:668798

Biochem Pharmacol, 2021, 190:114642

S3169^New

2'-Deoxyuridine 5'-monophosphate disodium salt

2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.

Catalog No.	Information	Product Use Citations
S5790^New	Folinic acid Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).
S5971^New	Pemetrexed Pemetrexed (LY231514, Alimta) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Br J Cancer, 2021, 10.1038/s41416-021-01441-7 Front Oncol, 2021, 11:668798 Biochem Pharmacol, 2021, 190:114642
S3169^New	2'-Deoxyuridine 5'-monophosphate disodium salt 2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.