Thymidylate Synthase
Inhibitory Selectivity
Thymidylate Synthase Products
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S5790 |
Folinic acidFolinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS). |
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S5971 |
PemetrexedPemetrexed (LY231514, Alimta) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis. |
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S3169 |
2'-Deoxyuridine 5'-monophosphate disodium salt2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth. |
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S5790 |
Folinic acidFolinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS). |
||
S5971 |
PemetrexedPemetrexed (LY231514, Alimta) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis. |
||
S3169 |
2'-Deoxyuridine 5'-monophosphate disodium salt2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth. |